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Human oncogenes

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Summary

The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, protooncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized. Finally, the concerted or sequential action of cellular transforming genes in the multistep process of carcinogenesis is discussed.

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  1. Institut für Zellbiologie (Tumorforschung), Universität Essen (GH), Hufelandstraße 55, D-4300, Essen 1, Federal Republic of Germany

    K. Willecke & R. Schäfer

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  1. K. Willecke
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  2. R. Schäfer
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Willecke, K., Schäfer, R. Human oncogenes. Hum Genet 66, 132–142 (1984). https://doi.org/10.1007/BF00286587

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