Summary
The semicontinuous production of chlortetracycline by immobilized cells of Streptomyces aureofaciens ATCC 10762 was compared with that of free cells. Immobilized cells transferred repeatedly to a new production medium, showed a fourfold increase in the half life time of antibiotic production.
In an air bubble column a high chlortetracycline productivity was obtained with a high aeration rate.
A semicontinuous production of chlortetracycline by immobilized S. aureofaciens could be improved by varying the fermentation conditions.
For continuous chlortetracycline production by immobilized cells, no improvement was detected.
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References
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Mahmoud, W., Rehm, H.J. Chlortetracycline production with immobilized Streptomyces aureofaciens . Appl Microbiol Biotechnol 26, 338–341 (1987). https://doi.org/10.1007/BF00256665
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DOI: https://doi.org/10.1007/BF00256665