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Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells

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Environment and Female Reproductive Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1300))

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are widely spread persistent environmental toxicants. Its typical representative benzo[a]pyrene (BaP) is a human carcinogen. BaP can pass through the placental barrier and is finally metabolized into benzo[a]pyren-7, 8-dihydrodiol-9, 10-epoxide (BPDE). BPDE can form DNA adducts, which directly affect the female reproductive health. Based on the special physiological functions of trophoblast cells and its important effect on normal pregnancy, this chapter describes the toxicity and molecular mechanism of BPDE-induced dysfunctions of trophoblast cells. By affecting the invasion, migration, apoptosis, proliferation, inflammation, and hormone secretion of trophoblast cells, BPDE causes diseases such as choriocarcinoma, intrauterine growth restriction, eclampsia, and abortion. In the end, it is expected to provide a scientific basis and prevention approach for women’s reproductive health and decision-making basis for the formulation of environmental health standards.

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Author information

Authors and Affiliations

  1. Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health, Sichuan University, Chengdu, China

    Rong Wang, Xinying Huang, Chenglong Ma & Huidong Zhang

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  1. Rong Wang
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  2. Xinying Huang
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  3. Chenglong Ma
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  4. Huidong Zhang
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Correspondence to Huidong Zhang .

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Editors and Affiliations

  1. Public Health School of West China, Sichuan University, Chengdu, Sichuan, China

    Huidong Zhang

  2. Reproductive Medicine Center, Peking University Third Hospital, Beijing, China

    Jie Yan

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Wang, R., Huang, X., Ma, C., Zhang, H. (2021). Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells. In: Zhang, H., Yan, J. (eds) Environment and Female Reproductive Health. Advances in Experimental Medicine and Biology, vol 1300. Springer, Singapore. https://doi.org/10.1007/978-981-33-4187-6_7

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