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Application of Nanomaterials in the Diagnosis and Treatment of Genetic Disorders

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Applications of Nanomaterials in Human Health

Abstract

Genetic testing is focused on identifying chromosome, gene, or protein changes between healthy and diseased cells or person. Genetic test outcomes can either verify or rule out possible genetic conditions and help determine whether a person is likely to develop or pass a genetic disorder. There are currently more than 1000 genetic testing and many more in the development pipeline. Therefore, the need to develop a susceptible and reliable method is vital in the diagnosis of genetic disorders. Nanomaterials offer a futuristic diagnosis platform for genetic diseases as it is a non-invasive, simple, portable, inexpensive diagnostic platform. Different nanomaterials have also been developed and functionlized with the target molecules to provide therapeutic selectively and for molecular imaging. For these reasons, the development of nanomaterials for the early detection of specific disease biomarkers in tiny amounts reaches to part-per-billion (ppb) levels, in real-time, with high sensitivity and selectivity and reliability is of great importance in disease diagnosis and disease progression monitoring. Such nanomaterials should have exceptionally high sensitivity and selectivity that combines the optical, magnetic, and electrical properties of nanomaterials with the biological selectivity and sensitivity toward their targets.

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Change history

  • 13 August 2020

    The original version of the book was inadvertently published with a spelling error in an author’s surname in Chapter 7. The author’s (7th author) name has now been corrected as “Murtaza M. Tambuwala”.

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Acknowledgments

The deanship of scientific research supported this work with grant.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid, Jordan

    Alaa A. Aljabali, Mohammad A. Obeid, Meriem M. Rezigue & Yassmen Hamzat

  2. Faculty of Pharmacy, Department of Pharmacy Practice, Yarmouk University, Irbid, Jordan

    Haneen A. Amawi

  3. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija

  4. School of Pharmacy and Pharmaceutical Science, SAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, UK

    Murtaza M. Tambuwala

Authors
  1. Alaa A. Aljabali
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  2. Mohammad A. Obeid
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  3. Haneen A. Amawi
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  4. Meriem M. Rezigue
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  5. Yassmen Hamzat
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  7. Murtaza M. Tambuwala
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Correspondence to Alaa A. Aljabali .

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  1. Department of Stem Cell Biology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Firdos Alam Khan

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Aljabali, A.A. et al. (2020). Application of Nanomaterials in the Diagnosis and Treatment of Genetic Disorders. In: Khan, F. (eds) Applications of Nanomaterials in Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-15-4802-4_7

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