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Autophagy and Heart Failure

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Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1207))

Abstract

Pressure overload can lead to cardiac hypertrophy and heart failure. Autophagic activity could be detected in heart failure patients and animal models. However, the role of autophagy in heart failure is not clear. In this chapter, we will outline the role of macroautophagy and mitophagy in heart failure and the mechanisms underlying regulation.

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References

  • Delbridge LMD, Mellor KM, Taylor DJ et al (2017) Myocardial stress and autophagy: mechanisms and potential therapies. Nat Rev Cardiol 14:412–425

    Article  CAS  Google Scholar 

  • Kostin S, Pool L, Elsasser A et al (2003) Myocytes die by multiple mechanisms in failing human hearts. Circ Res 92:715–724

    Article  CAS  Google Scholar 

  • Lavandero S, Chiong M, Rothermel BA et al (2015) Autophagy in cardiovascular biology. J Clin Invest 125:55–64

    Article  Google Scholar 

  • Li Z, Song Y, Liu L et al (2017) miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ 24:1205–1213

    Article  CAS  Google Scholar 

  • Martinet W, Knaapen MW, Kockx MM et al (2007) Autophagy in cardiovascular disease. Trends Mol Med 13:482–491

    Article  CAS  Google Scholar 

  • Rothermel BA, Hill JA (2007) Myocyte autophagy in heart disease: friend or foe? Autophagy 3:632–634

    Article  CAS  Google Scholar 

  • Shires SE, Gustafsson AB (2015) Mitophagy and heart failure. J Mol Med (Berl) 93:253–262

    Article  CAS  Google Scholar 

  • Song L, Su M, Wang S et al (2014) miR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. J Cell Mol Med 18:2266–2274

    Article  CAS  Google Scholar 

  • Sun T, Li MY, Li PF et al (2018) MicroRNAs in Cardiac autophagy: small molecules and big role. Cells 7

    Google Scholar 

  • Ucar A, Gupta SK, Fiedler J et al (2012) The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 3:1078

    Article  Google Scholar 

  • Wang B, Nie J, Wu L et al (2018) AMPKalpha2 protects against the development of heart failure by enhancing mitophagy via PINK1 phosphorylation. Circ Res 122:712–729

    Article  CAS  Google Scholar 

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Correspondence to Jie Du .

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Du, J., Liu, Y., Fu, J. (2020). Autophagy and Heart Failure. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_16

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