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Ca(2+) Ion and Autophagy

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Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1206))

Abstract

Controlled by a strict mechanism, intracellular calcium (Ca(2+)) is closely related to various cellular activities, including the regulation of autophagy. Researchers believed that under normal or stress state, Ca(2+) has a positive or negative regulation effect on autophagy, the mechanisms of which are different. This bidirectional role of Ca(2+), promotive or suppressing in the regulation of autophagy under different conditions remains controversial, so as the potential mechanisms. Several studies reported that Ca(2+) promotes autophagy through plenty of ways, like inositol 1,4,5-trisphosphate receptor (IP3R) and beclin1 pathway, calmodulin-dependent kinase kinase beta (CaMKKβ)–AMPK–mTOR pathway, mitochondrial energy metabolism-related Ca(2+) uptake, lysosome’s regulation of Ca(2+) signal, and so on. Others thought Ca(2+) may inhibit autophagy through IP3R and beclin1–Bcl-2 complex and the AMPK–mTOR pathway, either. It seems to be still a long way to thoroughly understand the truth of Ca(2+) and autophagy.

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Abbreviations

[Ca(2+)]cyt:

Cytoplasmic calcium concentration

[Ca(2+)]ER:

Endoplasmic reticulum calcium concentration

2-APB:

2-Aminoethoxydiphenyl borate

AMP:

Adenosine monophosphate

AMPK:

Adenosine 5′-monophosphate (AMP)-activated protein kinase

Atg:

Autophagy associated gene

ATP:

Adenosine triphosphate

Ca(2+):

Calcium ion

CaMKK:

Calmodulin-dependent protein kinase kinase

cAMP:

Cyclic adenosine monophosphate

CICR:

Calcium-induced Ca(2+) release

DAPK:

Death-associated protein kinase

DRAM:

Damage-regulated autophagy modulator

Epac:

Exchange protein directly activated by cAMP

GFP:

Green fluorescent protein

GPN:

Glycine-L-phenylalanine amide-naphthalene

IMPase:

Inositol monophosphatase

IP3:

1,4,6-inositol triphosphate

IP3R:

1,4,5-inositol triphosphate receptor

LC3:

Microtubule-associated protein 1 light chain 3

LRRK:

Leucine-rich repeat kinase

mTOR:

Mammalian target of rapamycin

NAADP:

Nicotinic acid adenine dinucleotide phosphate

NAD:

Nicotinamide adenine dinucleotide

NADH:

Reduced form of nicotinamide-adenine dinucleotid

OCR:

Oxygen consumption rate

PDH:

Pyruvate dehydrogenase

PLC:

Phospholipase C

PTP:

Permeability transition pore

ROS:

Reactive oxygen species

SERCA:

Sarco/endoplasmic reticulum Ca(2+) ATPase

siRNA:

Small interfering RNA

SNAREs:

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor

TPCs:

Two-pore channels

TRP:

Transient receptor potential channel

TRPML:

Transient receptor potential channel, mucolipin subfamily

ULK:

Uncoordinated 51-like kinase

VDAC:

Voltage-dependent anion-selective channel

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Author information

Authors and Affiliations

  1. Department of Cardiology, Shanghai Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China

    Yang-Xi Hu

  2. CAS Key Lab of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China

    Xiao-Shuai Han & Qing Jing

Authors
  1. Yang-Xi Hu
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  2. Xiao-Shuai Han
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  3. Qing Jing
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Corresponding author

Correspondence to Qing Jing .

Editor information

Editors and Affiliations

  1. Jiangsu Key Laboratory of Neuropsychiatric Diseases, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, College of Pharmaceutical Sciences of Soochow University, Suzhou, China

    Zheng-Hong Qin

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Hu, YX., Han, XS., Jing, Q. (2019). Ca(2+) Ion and Autophagy. In: Qin, ZH. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1206. Springer, Singapore. https://doi.org/10.1007/978-981-15-0602-4_7

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