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Membrane Permeabilization Mechanisms

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Antimicrobial Peptides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1117))

Abstract

Many antimicrobial peptides are considered to kill microbes by permeabilizing cell membranes. This chapter summarizes the driving force of peptide binding to membranes; various mechanisms of lipid bilayer permeabilization including the barrel-stave, toroidal pore, and carpet models; and modes of permeabilization of bacterial and mammalian membranes.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan

    Katsumi Matsuzaki

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  1. Katsumi Matsuzaki
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Correspondence to Katsumi Matsuzaki .

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  1. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan

    Katsumi Matsuzaki

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Matsuzaki, K. (2019). Membrane Permeabilization Mechanisms. In: Matsuzaki, K. (eds) Antimicrobial Peptides. Advances in Experimental Medicine and Biology, vol 1117. Springer, Singapore. https://doi.org/10.1007/978-981-13-3588-4_2

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