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Terpenes of the Genus Salvia: Cytotoxicity and Antitumoral Effects

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Anticancer Plants: Natural Products and Biotechnological Implements

Abstract

Plants are an important source of natural compounds used in cancer chemotherapy. The Salvia genus includes around 900 species worldwide and is an important source of terpenes, a group of secondary metabolites. According to an estimate, 111 terpenes are isolated from 24 Salvia species till date, and only 48 terpenes showed the cytotoxic activity. Out of 24 species, 16 are the native of Asia and 7 of America and 1 is from Europe. On the basis of the chemical compounds, 82 correspond to diterpenes, 4 sesterpenoids, 16 sesquiterpenes, and 9 triterpenes. Out of total diterpenes, five (ferruginol, sclareol, cryptotanshinone, tanshinone I, and tanshinone IIA) have been tested for their antitumoral effect. The present chapter described detail account of terpenes isolated from plants of the Salvia genus with their cytotoxic and antitumor activity.

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Acknowledgments

The authors wish to thank the Directorate for Research Support and Postgraduate Programs at the University of Guanajuato for their support in the editing of the English-language version of this book chapter.

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Authors and Affiliations

  1. Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Ciudad de México, Mexico

    Nimsi Campos-Xolalpa

  2. Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico

    Salud Pérez-Gutiérrez & Cuauhtémoc Pérez-González

  3. Instituto Nacional de Cáncer, Ciudad de México, Mexico

    Julia Mendoza-Pérez

  4. Departamento de Farmacia, Universidad de Guanajuato, Guanajuato, Mexico

    Angel Josabad Alonso-Castro

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  1. Nimsi Campos-Xolalpa
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  3. Cuauhtémoc Pérez-González
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  4. Julia Mendoza-Pérez
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Correspondence to Angel Josabad Alonso-Castro .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Campos-Xolalpa, N., Pérez-Gutiérrez, S., Pérez-González, C., Mendoza-Pérez, J., Alonso-Castro, A.J. (2018). Terpenes of the Genus Salvia: Cytotoxicity and Antitumoral Effects. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Natural Products and Biotechnological Implements. Springer, Singapore. https://doi.org/10.1007/978-981-10-8064-7_8

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