Abstract
STAT proteins have intrigued molecular and structural biologists for many years. The seemingly simple mechanism of activation through well known signalling components and the vast biological versatility of their functions had to be reconciled. Much hope rested on information gained from the structural features of the STAT molecules. The same is true for insights into the binding partners of STATs, molecules which might distinguish STAT functions in different cell types and as a result of different signalling origins. The goal of these studies is the merger of the combinatorial action of STAT molecules with other signal components responsible for distinct biological outcomes and the structural basis for such protein-protein interactions.
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Müller, C.W., Soler-Lopez, M., Gewinner, C., Groner, B. (2003). X-Ray Crystal Structure of STAT Proteins and Structure-Activity Relationships. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_21
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DOI: https://doi.org/10.1007/978-94-017-3000-6_21
Publisher Name: Springer, Dordrecht
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