Abstract
Nonsteroidal anti-inflammatory agents have a history of successful use in the acute treatment of migraine. In particular, ibuprofen is an approved OTC medication with proven efficacy in migraine. Caffeine is an analgesic adjuvant, commonly used in prescription drugs for migraine. The combination of ibuprofen and caffeine therefore seemed promising as a potential OTC treatment for migraine. In a single dose, double blind, placebo-controlled parallel and 3 way crossover study we compared the efficacy of ibuprofen 400 mg (I), ibuprofen 400 mg + caffeine 200 mg (I+C), and Placebo (P). A total of 96 subjects were stratified by general and randomised to receive all three study medications in one of six treatment sequences.
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© 1998 Springer Science+Business Media New York
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Stewart, W.F., Lipton, R.B. (1998). Ibuprofen Plus Caffeine in the Treatment of Migraine. In: Rainsford, K.D., Powanda, M.C. (eds) Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4878-8_11
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DOI: https://doi.org/10.1007/978-94-011-4878-8_11
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6044-8
Online ISBN: 978-94-011-4878-8
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