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Cell Proliferation and the Principles of Cancer Therapy

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Assessment of Cell Proliferation in Clinical Practice

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Abstract

The guiding principles on which a great deal of modern cancer therapy is based originate with experiments undertaken by Skipper and colleagues in the 1960s (Skipper et al. 1964, 1967). As a result of his investigations of experimental tumour systems, Skipper concluded that a given dose or course of (chemo)therapy will kill a constant fraction of the cell population, rather than a constant number of cells. He went on to consider the consequences of tumours having different growth rates, and concluded that chemotherapy gave a greater fractional cell-kill to more rapidly growing tumours, and was more likely to be curative in such cases (Skipper and Perry 1970). It also appeared that larger tumours generally grew more slowly, and that the lack of responsiveness of such tumours was related to this slower rate of proliferation (Shackney 1970; Steel et al. 1976).

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Authors
  1. W. M. Gregory
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Editors and Affiliations

  1. Department of Histopathology, UMDS, St Thomas’ Hospital, London, SE1 7EH, UK

    Peter A. Hall BSc, MD, MRCPath (Professor of Histopathology) (Professor of Histopathology)

  2. Department of Histopathology, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    David A. Levison MD, FRCPath (Professor of Histopathology) (Professor of Histopathology)

  3. Imperial Cancer Research Fund, Lincoln’s Inn Fields, London, WC2A 3PN, UK

    Nicholas A. Wright MA, MD, PhD, DSc, FRCPath (Director of Clinical Research, Professor and Director) (Director of Clinical Research, Professor and Director)

  4. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12 0NN, UK

    Nicholas A. Wright MA, MD, PhD, DSc, FRCPath (Director of Clinical Research, Professor and Director) (Director of Clinical Research, Professor and Director)

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© 1992 Springer-Verlag London Limited

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Gregory, W.M. (1992). Cell Proliferation and the Principles of Cancer Therapy. In: Hall, P.A., Levison, D.A., Wright, N.A. (eds) Assessment of Cell Proliferation in Clinical Practice. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68287-5_11

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  • DOI: https://doi.org/10.1007/978-4-431-68287-5_11

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68289-9

  • Online ISBN: 978-4-431-68287-5

  • eBook Packages: Springer Book Archive

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