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Role of Endothelium in Control of Regional Blood Flow in Humans

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Cardiac-Vascular Remodeling and Functional Interaction

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Summary

We have studied the role of endothelium in control of forearm blood flow in patients with heart failure as well as in normal subjects. First, endothelium-dependent forearm vasodilation in response to acetylcholine (ACh), substance P, and endothelium-independent forearm vasodilation to sodium nitroprusside (SNP) were examined in patients with heart failure and in normal subjects. Endothelium-dependent forearm vasodilation in response to ACh but not to substance P was impaired in patients with heart failure. Endothelium-independent forearm vasodilation to SNP was also preserved in patients with heart failure. Second, the role of nitric oxide (NO) in reactive hyperemia and exercise-induced vasodilation were examined using N G-monomethyl-l-arginine (l-NMMA), a blocker of NO synthesis, in normal subjects. Results suggested that NO plays a minimal role in reactive hyperemia and exercise-induced vasodilation in normal human forearm vessels. Finally, we determined if l-arginine, a precursor of NO, improves impaired endothelium-dependent vasodilation to ACh and reactive hyperemia in patients with heart failure. l-Arginine augmented impaired ACh-induced vasodilation as well as reactive hyperemia in patients with heart failure. Our results suggested that defective endothelial function may contribute to abnormal control of regional blood flow in patients with heart failure.

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References

  1. Félétou M, Canet E, Vanhoutte PM (1994) Endothelial NO and vascular regulation. In: Masaki T (ed) Endothelium-derived factors and vascular functions. Elsevier, Amsterdam, pp 47–59

    Google Scholar 

  2. Vanhoutte PM, Boulanger CM (1995) Endothelium-dependent responses in hypertension. Hypertens Res 18: 87–98

    Article  PubMed  CAS  Google Scholar 

  3. Drexler H (1995) Changes in the peripheral circulation in heart failure. Curr Opin Cardiol 10: 268–273

    Article  PubMed  CAS  Google Scholar 

  4. Kiowski W (1991) Endothelial function in humans. Studies of forearm resistance vessels. Hypertension 18(suppl II):II-84-II-89

    Google Scholar 

  5. Benjamin N, Calver A, Collier J, Robinson B, Valiance P, Webb D (1995) Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertension (Dallas) 25: 918–923

    Article  CAS  Google Scholar 

  6. Zelis R, Sinoway L, Musch T, Davis D (1989) Vasoconstrictor mechanisms in congestive heart failure. Part 1. Mod Concepts Cardiovasc Dis 58: 7–12

    Google Scholar 

  7. Hirooka, Y, Imaizumi T, Takeshita A, Ando S, Harada S (1990) Endothelium-dependent forearm vasodilation to intra-arterial acetylcholine is impaired in patients with heart failure. Circulation 82: III - 591

    Article  Google Scholar 

  8. Kubo S, Rector TS, Bank A], Williams RE, Heifetz SM (1991) Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation 84: 1589–1596

    Article  PubMed  CAS  Google Scholar 

  9. Katz SD, Biasucci L, Sabba C, Strom JA, Jondeau G, Balvao M, Solomon S, Nikolic SD, Forman R, Lejemtel TH (1992) Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J Am Coll Cardiol 19: 918–925

    Article  PubMed  CAS  Google Scholar 

  10. Drexler H, Hayoz D, Munzel T, Hornig B, Just H, Brunner HR, Zelis R (1992) Endothelial function in chronic congestive heart failure. Am J Cardiol 69: 1596–1601

    Article  PubMed  CAS  Google Scholar 

  11. Hirooka Y, Imaizumi T, Harada S, Masaki H, Momohara M, Tagawa T, Takeshita A (1992) Endothelium-dependent forearm vasodilation with acetylcholine but not to substance P is impaired in patients with heart failure. J Cardiovasc Pharmacol 20 (suppl 12): S221 - S225

    Article  PubMed  Google Scholar 

  12. Hirooka Y, Takeshita A, Imaizumi T, Suzuki S, Yoshida M, Ando S, Nakamura M (1990) Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure. Circulation 82: 147–153

    Article  PubMed  CAS  Google Scholar 

  13. Imaizumi T, Takeshita A, Suzuki S, Yoshida M, Ando S, Nakamura M (1990) Age-independent forearm vasodilation by acetylcholine and adenosine 5’-triphosphate in human. Clin Sci 78: 89–93

    PubMed  CAS  Google Scholar 

  14. Förstermann U, Mügge A, Alheid U, Haverich A, Frölich JC (1988) Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. Circ Res 62: 185–190

    Article  PubMed  Google Scholar 

  15. Panza J, Casino PR, Kilcoyne CM, Quyyumi AA (1994) Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. J Am Coll Cardiol 23: 1610–1616

    Article  PubMed  CAS  Google Scholar 

  16. Cockcroft JR, Chowienczyk PJ, Brettt SE, Ritter JM (1994) Effects of NG-monomethylL-arginine on kinin-induced vasodilation in the human forearm. Br J Clin Pharmacol 38: 307–310

    Article  PubMed  CAS  Google Scholar 

  17. Miller VM, Vanhoutte PM (1988) Enhanced release of endothelium-derived factor(s) by chronic increases in blood flow. Am J Physiol 255: H446 - H451

    PubMed  CAS  Google Scholar 

  18. Ontkean M, Gay R, Greenberg B (1991) Diminished endothelium-derived releasing factor activity in an experimental model of chronic heart failure. Circ Res 69: 10881096

    Google Scholar 

  19. Belch JJF, Bridges AB, Scott N, Chopra M (1991) Oxygen free radicals and congestive heart failure. Br Heart J 65: 245–248

    Article  PubMed  CAS  Google Scholar 

  20. Hirooka Y, Imaizumi T, Masaki H, Ando S, Harada S, Momohara M, Takeshita A (1992) Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients. Hypertension 20: 175–180

    Article  PubMed  CAS  Google Scholar 

  21. Katz S, Rao R, Berman JW, Schwarz M, Demopoulos L, Bijou R, LeJemtel TH (1994) Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Circulation 90: 12–16

    Article  PubMed  CAS  Google Scholar 

  22. Shiramoto M, Imaizumi T, Namba T, Endo T, Takeshita A (1994) Are vasodilator effects of substance P and ATP mediated by nitric oxide in human forearm vessels? Circulation 90: I - 321

    Google Scholar 

  23. Vallance P, Collier J, Moncada S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2: 997–1000

    Article  PubMed  CAS  Google Scholar 

  24. Panza J, Casino PR, Kilcoyne CM, Quyyumi AA (1993) Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 87: 1468–1474

    Article  PubMed  CAS  Google Scholar 

  25. Imaizumi T, Hirooka Y, Masaki H, Harada S, Momohara M, Tagawa T, Takeshita A (1992) Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 20: 511–517

    Article  PubMed  CAS  Google Scholar 

  26. Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A (1994) Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation 90: 22852290

    Google Scholar 

  27. Endo T, Imaizumi T, Tagawa T, Shiramoto M, Ando S, Takeshita A (1994) Role of nitric oxide in exercise-induced vasodilation of the forearm. Circulation 90: 28862890

    Google Scholar 

  28. Yamabe H, Okumura K, Ishizaka H, Tsuchiya T, Yasue H (1992) Role of endothelium-derived nitric oxide in myocardial reactive hyperemia. Am J Physiol 263: H8 - H14

    PubMed  CAS  Google Scholar 

  29. Kostic MM, Schrader J (1992) Role of nitric oxide in reactive hyperemia of the guinea pig heart. Circ Res 70: 208–212

    Article  PubMed  CAS  Google Scholar 

  30. Wolin MS, Rodenburg JM, Messina EJ, Kaley G (1990) Similarities in the pharmacological modulation of reactive hyperemia and vasodilation to hydrogen peroxide in rat skeletal muscle arterioles: effects of probes for endothelium-derived mediators. J Pharmacol Exp Ther 253: 508–512

    PubMed  CAS  Google Scholar 

  31. Koller A, Kaley G (1990) Prostaglandins mediate arteriolar dilation to increased blood flow velocity in skeletal muscle microcirculation. Circ Res 67: 529–534

    Article  PubMed  CAS  Google Scholar 

  32. Messina EJ, Sun D, Koller A, Wolin MS, Kaley G (1992) Role of endothelium-derived prostaglandins in hypoxia-elicited arteriolar dilation on rat skeletal muscle. Circ Res 71: 790–796

    Article  PubMed  CAS  Google Scholar 

  33. Tagawa T, Imaizumi T, Endo T, Shiramoto M, Hirooka Y, Ando S, Takeshita A (1993) Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels. J Clin Invest 92: 1483–1490

    Article  PubMed  CAS  Google Scholar 

  34. Kilbom A, Wennmalm A (1976) Endogenous prostaglandins as local regulators of blood flow in man: effect of indomethacin on reactive and functional hyperemia. J Physiol 257: 109–121

    PubMed  CAS  Google Scholar 

  35. Carlson I, Sollevi I, Wennmalm A (1987) The role of myogenic relaxation, adenosin and prostaglandins in human forearm reactive hyperemia. J Physiol (Lond) 389: 147161

    Google Scholar 

  36. Aversano T, Ouyang P, Silverman H (1991) Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation. Circ Res 69: 618–622

    Article  PubMed  CAS  Google Scholar 

  37. Kanatsuka H, Sekiguchi N, Sato K, Akai K, Wang Y, Komaru T, Ashikawa K, Takishima T (1992) Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart. Circ Res 71: 912–922

    Article  PubMed  CAS  Google Scholar 

  38. Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA (1994) Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90: 2853–2858

    Article  PubMed  CAS  Google Scholar 

  39. Hirooka Y, Imaizumi T, Tagawa T, Shiramoto M, Endo T, Ando S, Takeshita A (1994) Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation 90: 658–668

    Article  PubMed  CAS  Google Scholar 

  40. Drexler H, Zeiher AM, Meinzer K, Just H (1991) Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 338: 1546–1550

    Article  PubMed  CAS  Google Scholar 

  41. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP (1992) LArginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 90: 1248–1253

    Article  PubMed  CAS  Google Scholar 

  42. Panza JA, Casino PR, Badar DM, Quyyumi AA (1993) Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 87: 1475–1481

    Article  PubMed  CAS  Google Scholar 

  43. Linder L, Kiowski W, Buhler FR, Luscher TF (1990) Indirect evidence for release of endothelium-derived relaxing factors in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 81: 1762–1767

    Article  PubMed  CAS  Google Scholar 

  44. Katz S, Schwarz M, Yuen J, LeJemetel TH (1993) Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Circulation 88: 55–61

    Article  PubMed  CAS  Google Scholar 

  45. Takeshita A, Imaizumi T, Ashihara T, Yamamoto K, Hoka S, Nakamura M (1982) Limited maximal vasodilator capacity of forearm resistance vessels in normotensive young men with a familial predisposition to hypertension. Circ Res 51: 457–464

    Article  PubMed  CAS  Google Scholar 

  46. Zelis R, Mason DT, Braunwald E (1968) A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest 47: 960–970

    Article  PubMed  CAS  Google Scholar 

  47. Sinoway L, Minotti J, Musch T, Goldner D, Davis D, Leaman D, Zelis R (1987) Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease. Am J Cardiol 60: 107–111

    Article  PubMed  CAS  Google Scholar 

  48. Kubo S, Rector TS, Bank AJ, Raij L, Kraemer MD, Tadros P, Beardslee M, Garr MD (1994) Lack of contribution of nitric oxide to basal vasomotor tone in heart failure. Am J Cardiol 74: 1133–1136

    Article  PubMed  CAS  Google Scholar 

  49. Mancini D, Davis L, Wexler JP, Chadwick B, Lejemtel TH (1987) Dependence of enhanced maximal exercise performance on increased peak skeletal muscle perfusion during long-term captopril therapy in heart failure. J Am Coll Cardiol 10: 845–850

    Article  PubMed  CAS  Google Scholar 

  50. Imaizumi T, Takeshita A, Nakamura N, Sakai K, Hirooka Y, Suzuki S, Yoshida M, Nakamura M (1990) Effects of captopril on forearm oxygen consumption during dynamic handgrip exercise in patients with congestive heart failure. Jpn Heart J 31: 817–828

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University School of Medicine, Fukuoka, 812-82, Japan

    Yoshitaka Hirooka & Akira Takeshita

  2. Third Department of Internal Medicine, Kurume University School of Medicine, Kurume, 830, Japan

    Tsutomu Imaizumi

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  1. Yoshitaka Hirooka
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  2. Tsutomu Imaizumi
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  3. Akira Takeshita
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Editors and Affiliations

  1. First Department of Internal Medicine, Fukushima Medical College, Hikariga-oka 1, 960-12, Fukushima, Japan

    Yukio Maruyama M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565, Japan

    Masatsugu Hori M.D., Ph.D. (Chief) (Chief)

  3. College of Veterinary Medicine, Auburn University, 106 Greene Hall, 36849-5517, Auburn, AL, USA

    Joseph S. Janicki Ph.D. (Professor, Associate Dean of Research and Graduate Studies) (Professor, Associate Dean of Research and Graduate Studies)

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© 1997 Springer Japan

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Hirooka, Y., Imaizumi, T., Takeshita, A. (1997). Role of Endothelium in Control of Regional Blood Flow in Humans. In: Maruyama, Y., Hori, M., Janicki, J.S. (eds) Cardiac-Vascular Remodeling and Functional Interaction. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67041-4_21

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  • DOI: https://doi.org/10.1007/978-4-431-67041-4_21

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67043-8

  • Online ISBN: 978-4-431-67041-4

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