Synonyms
Definition
Exposure of cellular DNA to solar radiation including UVB (290 < λ <320 nm) and UVA (320 < λ < 400 nm) gives rise through direct excitation of nucleobases and photosensitized reactions to the formation of several classes of photodamage. These consist predominantly of bipyrimidine lesions that include cyclobutane pyrimidine photoproducts (CPDs), pyrimidine (6-4) pyrimidone (6-4PPs) photoadducts, and their Dewar valence isomers (DEWs). In addition, oxidation reactions that are mostly triggered by UVA-excited endogenous photosensitizers generate mainly 8-oxo-7,8-dihydroguanine (8-oxoGua) with smaller amounts of oxidized pyrimidine bases and single-strand breaks at the exclusion of double-strand breaks (Fig. 1). Exogenous photosensitizers are also able to damage cellular DNA according to several mechanisms that are either oxygen independent such as triplet energy transfer and photocycloaddition reactions or involve the participation...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cadet J, Wagner JR (2013) DNA base damage by reactive oxygen species, oxidizing agents and UV radiation, Cold Spring Harb Perspect Biol 5:a012559
Cadet J, Douki T, Ravanat J-L (2015) Oxidatively generated damage to cellular DNA by UVB and UVA radiation, Photochem Photobiol 91:140–155
Cadet J, Grand A, Douki T (2015) Solar UV radiation-induced DNA bipyrimidine photoproducts: formation and mechanistic insights. Top Curr Chem 571:3–17
Mouret S, Charveron M, Favier A, Cadet J, Douki T (2008) Differential repair of UVB-induced cyclobutane pyrimidine dimers in cultured human skin cells and whole human skin. DNA Repair (Amst) 7:704–712
Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE (2015) Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 347:842–847
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Cadet, J., Douki, T., Béani, JC. (2014). Photo-Induced DNA Damage. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_7155
Download citation
DOI: https://doi.org/10.1007/978-3-662-46875-3_7155
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-46874-6
Online ISBN: 978-3-662-46875-3
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences