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Mechanisms of Glomerular Fibrin Deposition in Glomerulonephritis

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Nephrology

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Summary

Evidence points to glomerular fibrin deposition (GFD) as an important mediator of renal injury and crescent formation. GFD appears to be initiated by intraglomerular stimuli related to local immune inflammatory events. Macrophages expressing augmented procoagulant activity (PCA) are likely to be important initiators of GFD. Antibody Fc direction or delayed type hypersensitivity (DTH) mechanisms may be the primary initiating event. Other factors, including contact activation of coagulation and inhibition of fibrinolytic clearance, may act in concert to exacerbate fibrin accumulation, especially in Bowman’s space. The importance of GFD in human GN is highlighted by evidence that it may be prevented or reversed by therapeutic intervention, thereby offering the potential for limiting the progression of injury in these forms of GN.

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Authors and Affiliations

  1. Department of Medicine, Prince Henry’s Hospital, St. Kilda Road, Melbourne, 3004, Australia

    P. G. Tipping

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  1. S. R. Holdsworth
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Editors and Affiliations

  1. Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

    Michinobu Hatano M.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1991 Springer Japan

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Holdsworth, S.R., Tipping, P.G. (1991). Mechanisms of Glomerular Fibrin Deposition in Glomerulonephritis. In: Hatano, M. (eds) Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35158-1_15

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  • DOI: https://doi.org/10.1007/978-3-662-35158-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-70074-6

  • Online ISBN: 978-3-662-35158-1

  • eBook Packages: Springer Book Archive

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