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Detection of Myocardial Viability and Inducible Ischemia with Dobutamine

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

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Abstract

In 1973, Tuttle and Mills [1] developed a new synthetic catecholamine in order to obtain a molecule with a selective inotropic effect and moderate chronotropic, arrhythmogenic and vascular side effects. Twenty years after its birth, dobutamine is not only widely administred as a therapeutic agent but it is increasingly used as a diagnostic tool. Dobutamine has dose-dependent effects. At low dose, it can bring out the contractile reserve of viable myocardium in patients with acute myocardial infarction or chronic coronary artery disease (CAD). At higher doses, the drug still produces intense positive inotropic effects, but the development of tachycardia leads to an increase in myocardial oxygen consumption which can induce ischemia in myocardial regions perfused by arteries with reduced coronary flow reserve.

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Authors
  1. L. Galiuto
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  2. L. A. Pierard
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Galiuto, L., Pierard, L.A. (1996). Detection of Myocardial Viability and Inducible Ischemia with Dobutamine. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_48

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_48

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60552-2

  • Online ISBN: 978-3-642-80053-5

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