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Comparative Patch Testing with PPD-Base and PPD-Dihydrochloride: Human and Animal Data Compiled by the European Environmental Contact Dermatitis Research Group

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Current Topics in Contact Dermatitis

Summary

The replacement of PPD-base 1% petrolatum (pet.) by PPD-dihydrochloride 0.5% pet. in the ICDRG standard series in 1984 seems to have reduced considerably the number of positive reactions to PPD. Therefore, the EECDRG decided to perform comparative patch tests with PPD-base and PPD-dihydrochloride. The results in human testing showed that most of the PPD sensitivities were missed by the PPD-dihydrochloride. Guinea pig experiments confirmed that PPD-dihydrochloride was less able to elicit hypersensitivity reactions than PPD-base. Similar results were obtained with groups of guinea pigs sensitized by intradermal injection to either allergen preparation. The difference in molecular weights, different liabilities in oxidative degradation to the sensitizing intermediate, or different skin penetration capabilities may account for this phenomenon.

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References

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Author information

Authors and Affiliations

  1. Department of Medical Research (Dermatology), University Hospital, Leuven, Belgium

    A. Dooms-Goossens

  2. Department of Pathology, Free University Hospital, Amsterdam, The Netherlands

    R. J. Scheper

  3. Hudklinikken, Roskilde, Denmark

    K. E. Andersen

  4. Department of Dermatology, Royal Victoria Hospital, Belfast, Ireland

    D. Burrows

  5. Department of Dermatology, Universitat Autónoma de Barcelona, Spain

    J. G. Camarasa

  6. Universitäts-Hautklinik, Heidelberg, Germany

    P. J. Frosch

  7. Department of Dermatology, University of Oulo, Oulo, Finland

    A. Lahti

  8. Department of Dermatology, Wycombe General Hospital, High Wycombe, England

    J. Wilkinson

Authors
  1. A. Dooms-Goossens
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  2. R. J. Scheper
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  3. K. E. Andersen
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  4. D. Burrows
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  5. J. G. Camarasa
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  6. P. J. Frosch
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  7. A. Lahti
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  8. J. Wilkinson
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Editor information

Editors and Affiliations

  1. Hautklinik der Universität Heidelberg, Voßstraße 2, 6900, Heidelberg 1, Germany

    Peter Frosch

  2. Department of Medical Research (Dermatology), Katholieke Universiteit Leuven, 3000, Leuven, Belgium

    A. Dooms-Goossens P.Ph., Ph.D.

  3. Unit and Laboratory of Occupational and Environmental Dermatology, Catholic University of Louvain, 30, Clos Chapelle-aux-Champs, UCL 3033, 1200, Brussels, Belgium

    J.-M. Lachapelle M. D. (Professor of Dermatology) (Professor of Dermatology)

  4. St. John’s Hospital for Diseases of the Skin, Lisle Street, London, WC2H 7BJ, Great Britain

    R. J. G. Rycroft

  5. Department of Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. J. Scheper

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© 1989 Springer-Verlag Berlin Heidelberg

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Dooms-Goossens, A. et al. (1989). Comparative Patch Testing with PPD-Base and PPD-Dihydrochloride: Human and Animal Data Compiled by the European Environmental Contact Dermatitis Research Group. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_58

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  • DOI: https://doi.org/10.1007/978-3-642-74299-6_58

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74301-6

  • Online ISBN: 978-3-642-74299-6

  • eBook Packages: Springer Book Archive

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