Skip to main content
SpringerLink
Log in

Mechanisms of heart failure

  • Conference paper
Das Gesunde und Kranke Herz bei körperlicher Belastung

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung ((2849,volume 37))

Abstract

The question of why the myocardium fails to contact normally and ultimately leads to congestive failure, has occupied the attention of both clinicians and basic scientists for decades. Nevertheless, it is only within recent years that improvements in clinical diagnostic techniques and development of more sophisticated physiological and biochemical methods have permitted a broader understanding of and direct approach to the problem. Our present purpose is to review certain concepts dealing with myocardial failure on both a physiological and biochemical basis with emphasis on some of our most recent experimental work. In the process we would hope to redefine certain ground rules by which the problem may be approached, and review a number of experiments which have been conducted in our laboratories recently as well as over the past several years to explore the underlying bases of the failing heart.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alpert, N. R., and M. S. Gordon, Myofibrillar adinosine triphosphatase activity in congestive heart failure. Am. J. Physiol. 20, 2, 940 (1962).

    Google Scholar 

  2. Argus, M.F., J.C. Arcos, V. M. Sardesai & J. L. Overby, Oxidative rates and phosphorylation in sarcosomes from experimentally-induced failing rat heart. Proceed. Soc. Exper. Biol. Med. 117, 380 – 383.

    Google Scholar 

  3. Bajusz, E., Hereditary Cardiomyopathy. A new disease model. Amer. Heart J. 77, 686 (1969).

    Article  PubMed  CAS  Google Scholar 

  4. Bing, O. H., S. Matsushita, Barry L. Fanburg, and H. J. Levine, Mechanical Properties of Rat Cardiac Muscle during Experimental Hypertrophy. Circ. Res. 28, 234 (1971).

    PubMed  CAS  Google Scholar 

  5. Braunwald, E., J. Ross and E. H. Sonnenblick, Mechanisms of Contraction of the Normal and Failing Heart. ( Boston 1967 ) p. 62.

    Google Scholar 

  6. Briggs, F. N., E. W. Gertz, M. L. Hess, Calcium uptake by Cardiac Vesicles: Inhibition by Amytal and Reversal by Ouabain. Biochem. Z. 345, 122 (1966).

    CAS  Google Scholar 

  7. Brody, T. M., J. F. Palmer, and D. R. Bennett, Phosphorilation in cardiac cmuscle from failing and unfailing heart lung preparations. Proc. Soc. Exp. Biol. Med. 86, 740 (1954).

    Google Scholar 

  8. Buccino, R. A., T. Harris, J. F. Spann Jr., and E. H. Sonnenblick, Connective Tissue in Cardiac Hypertrophy. Am. J. Physiol. 216, 425 – 428 (1969).

    PubMed  CAS  Google Scholar 

  9. Chandler, B. M., E. H. Sonnenblick, J. F. Spann, and P. E. Pool, Association of depressed myofibrillar adenosine triphosphatase and reduced contractility in experimental heart failure. Circ. Res. 21. 717 (1967).

    CAS  Google Scholar 

  10. Chidsey, C. A., E. Braunwald, A. G. Morrow, Myocardial norepinephrine concentration in man: Effects of reserpine and of congestive heart failure. New Eng. J. Med. 269, 653 – 658 (1963).

    Article  CAS  Google Scholar 

  11. Chidsey, C. A., E. Braunwaldf A. G. Morrow, Catecholamine excretion and cardiac story of Norepinephrine in Congestive Heart Failure. Amer. J. Med. 39, 442- 451 (1965).

    Google Scholar 

  12. Covell, J. W., C. A. Chidsey, E. Braunwald, Reduction of the cardiac response to postganglionic sympathetic nerve stimulation in experimental heart failure. Circ. Res. 19, 51 – 56 (1966).

    Google Scholar 

  13. Forman, R., W. W. Parmley, and E. H. Sonnenblick, Myocardial Mechanics in hereditary cardiomyopathy of the Syrian Hamster. Circulation 42, 111–153 (1970) Abstract.

    Google Scholar 

  14. Fox, A. C., G. E. Reed, Exchanges of nucleotide phosphate in normal and in failing canine hearts. Amer. J. of Physiol. 110, 1383 – 1390 (1966).

    Google Scholar 

  15. Frank, O., Zur Dynamik des Herzmuskels. Z. Biol. 32, 370 (1895).

    Google Scholar 

  16. Furchgott, R. F., and T. De Gubareff, The high energy phosphate content of cardiac muscle under various experimental conditions which alter contractile strenght. J. Pharmacol. Exp. Ther. 124, 203 (1958).

    PubMed  CAS  Google Scholar 

  17. Gettler, M. M., Differences in efficiencies of energy transfer in mitochrondrial systems derived from normal and failing hearts. Proc. Soc. Exper. Biol. Med. 106, 109 – 112 (1961).

    Google Scholar 

  18. Gertz, E. W., M. L. Hess, R. F. Lain, F. N. Briggs, Activity of the vesicular calcium pump in the spontaneously failing heart – lung preparation. Circ. Res. 20, 433 (1967).

    Google Scholar 

  19. Gertz, E. W., A. C. Stam, E. H. Sonnenblick, Dissociation of Collagen Prolifiration from Hypertrophy in Experimental Cardiomyopathy. Amer. J. Cardiol. 26, 634 (1970).

    Article  Google Scholar 

  20. Gertz, E. W., A. C. Stam, E. H. Sonnenblick, A quantitative of qualitative defect in the sarcoplasmic reticulum in the hereditary cardiomyopathy of the Syrian Hamster. Biochim. Biophys. Res. Comm. 40, 746 (1970).

    Article  CAS  Google Scholar 

  21. Gordon, M. S. & N. L. Brown, Myofibrillar adenosine triphosphatase activity of human heart tissue in congestive failure: Effects of ouabain and calcium. Circ. Res. 18, 534 (1966).

    PubMed  CAS  Google Scholar 

  22. Harigayz, S. and A. Schwartz, Rate of calcium binding and uptake in normal animals and failing human cardiac muscle: Membrane Vesicles (relaxing system) and mitochondria. Circ. Res. 25, 781 (1969).

    Google Scholar 

  23. Katz, A. M. and H. H. Hect, The early „pump” failure of the ischemic heart. Editoria, Amer. J. Med. 47, 497 (1969).

    Article  CAS  Google Scholar 

  24. Kaufmann, R. L., H. Homburger and H. Wirth, Disorder in Excitation-Contraction Coupling of cardiac muscle from cats with experimentally produced right ventricular hypertrophy. Circ. Res. 28, 346 (1971).

    PubMed  CAS  Google Scholar 

  25. LaRaia, P. J., E. W. Gertz, E. H. Sonnenblick, Manuscript in preparation.

    Google Scholar 

  26. Lesch, M., W. W. Parmley, M. Hanash, S. Kaufmann, and E. H. Sonnenblick, Effects of Acute Hypertrophy on the Contractile Properties of Skeletal Muscle. Amer. J. Physiol. 214, 658 – 690 (1968).

    Google Scholar 

  27. Levitt, H., S. Spector, A. Sjoerdsma, and S. Undenfriend, Elucidation of the role limiting step in norepinephrine biosynthesis in the perfused guinea pig heart. J. Pharmacol. Exp. Ther. 148, 1 (1965).

    PubMed  CAS  Google Scholar 

  28. Lindenmeyer, G. E., S. Harisaya, E. Bajusz, and A. Schwartz, Oxidation Phosphorylation and Calcium Transport of Mitochondria Isolated from Cardiomyopathy Hamster Hearts. J. Mol & Cellular Cardiol. 1, 249 (1970).

    Article  Google Scholar 

  29. Lindenmeyer, G. E.f L. A. Sordahl, and A. Schwartz, Reevaluation of Oxidative phosphory lation of Cardiac mitochondria from normal animals and animals in heart failure. Circ. Res. 23, 439 (1968).

    Google Scholar 

  30. Luchi, R. J., E. M. Kritcher, and P. T. Thyrum, Reduced cardiac myosin adinosine triphosphatase activity in days with spontaneously occurring heart failure. Circ. Res. 24, 513 (1969).

    PubMed  CAS  Google Scholar 

  31. Milton, P. R., P. M. Toll, and L. R. Norman, Levels of Phosphate Compounds in Experimental Cardiac hypertrophy. Circ. Res. 8, 924 (1960).

    Google Scholar 

  32. Miyahara, M., Studies on actomyosin of heart muscle. Jap. Circ. J. (Eng. ed.) 26, 8 (1962).

    Google Scholar 

  33. Plaut, G. W. E. & M. M. Gertler, Oxidative phosphorylation studies in normal and experimentally produced congestive heart failure in guinea pigs; a comparison. Ann. New York Acad. Sci. 72, 515 – 517 (1959).

    Article  CAS  Google Scholar 

  34. Pool, P. E., Congestive heart failure: biochemical and physiology observations. Amer. J. Med. Sci. 258, 328 (1969).

    Article  PubMed  CAS  Google Scholar 

  35. Pool, P. E., J. W. Covell, M. Levitt, J. Gibb, and E. Braunwald, Reduction of cardiac tyrosine hydroxylase activity in experimental congestive failure: Its role in the depletion of cardiac norepinephrine stores. Circ. Res. 20, 349 – 353 (1967).

    PubMed  CAS  Google Scholar 

  36. Pool, P. E., J. F. Spann Jr., R. A. Buccino, E. H. Sonnenblick, and E. Braunwald, Myocardial high energy phosphate stores in cardiac hypertrophy and heart failure. Circ. Res. 21, 365 (1967).

    CAS  Google Scholar 

  37. Procita, L., A. Schwartz, and K. S. Lee, Oxidative phosphorylation in the failing dog heart lung preparation. Circ. Res. 16, 391 (1965).

    PubMed  CAS  Google Scholar 

  38. Ross J., Jr., J. W. Covell, and E. H. Sonnenblick, The Mechanics of Left Ventricular Contraction in Acute Experimental Cardiac Failure. J. Clin. Invest. 46. 299 – 312 (1967).

    Article  PubMed  Google Scholar 

  39. Ross, J., Jr., E. H. Sonnenblick, J. W. Covell, G. A. Kaiser, and D. Spiro, The Architecture of the Heart in Systole and Diastole. Technique of Rapid Fixation and Analysis of Left Ventricular Geometry. Circ. Res. 21, 409 – 421 (1967).

    PubMed  Google Scholar 

  40. Ross, J., Jr., E. H. Sonnenblick, R. R. Taylor, and J. W. Covell, Diastolic Geometry and Sarcomere Lengths in the Chronically Dilated Canine Left Ventricle. Circulation Res. 28, 49 – 61 (1971).

    PubMed  Google Scholar 

  41. Scheuer, J., Metabolism of the heart in cardiac failure. Progr. Cardiovasc. Dis., 13, 24 (1970).

    Article  CAS  Google Scholar 

  42. Schwartz, A., and K. S. Lee, Study of heart mitochondria and glycolytic metabolism in experimentally induced cardiac failure. Circ. Res. 10, 321 (1962).

    PubMed  CAS  Google Scholar 

  43. Sobel, B. E., P. D. Henry, A. Robinson, C. Bloor, and J. Ross Jr., Depressed Adenyl Cyclase activity in the failing guinea pig heart. Circ. Res. 24, 507 (1969).

    PubMed  CAS  Google Scholar 

  44. Sobel, B. E., J. F. Spann, P. E. Pool, E. H. Sonnenblick, and E. Braunwald, Normal oxidative phosphorylation in mitochondria from the failing heart. Circul. Res. 21, 355 – 363 (1967).

    CAS  Google Scholar 

  45. Sonnenblick, E. H., Correlation of myocardial ultrastructure and function. Circ. 38, 29 (1968).

    CAS  Google Scholar 

  46. Sonnenblick, E. H., J. Ross Jr., J. W. Covell, H. M. Spotnitz, and D. Spiro, The Ultrastructure of the Heart in Systole and Diastole. Changes in Sarcomere Length. Circ. Res. 21, 423 – 431 (1967).

    PubMed  CAS  Google Scholar 

  47. Sonnenblick, E. H., D. Spiro, and H. M. Spotnitz, The Ultrastructural Basis of Starling’s Law of the Heart. The Role of the Sarcomere in Determining Ventricular Size Stroke Volume. Am. Heart J. 68, 336 – 346 (1964).

    Article  PubMed  CAS  Google Scholar 

  48. Spann, J. F., R. A. Buccino, E. H. Sonnenblick, and E. Braunwald, Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure. Circ. Res. 21, 341 – 345 (1967).

    PubMed  Google Scholar 

  49. Spann, J. F., Jr., C. A. Chidsey, E. Braunwald, Reduction of cardiac stores of norepinephrine in experimental heart failure. Science 195, 1439 – 1447 (1964).

    Article  Google Scholar 

  50. Spann J. F., Jr., C. A. Chidsey, E. Pool, and E. Braunwald, Mechanism of norepinephrine depletion in experimental heart failure produced by aortic constriction in the guinea pig. Circ. Res. 17, 312 – 321 (1965).

    PubMed  CAS  Google Scholar 

  51. Spann, J. F., Jr., J. W. Covell, D. L. Eckberg, et al., Myocardial contractile state in hypertrophy and congestive failure: Studies in the heart and the solated muscle. Circul. 36 (Supp 11), 11 – 241 (1967).

    Google Scholar 

  52. Spann, J. F. Jr., E. H. Sonnenblick, T. Cooper, C. A. Chidsey, V. L. William, and E. Braunwald, Cardiac norepinephrine stores and the contractile state of the heart. Circ. Res. 19, 317 – 375 (1966).

    PubMed  CAS  Google Scholar 

  53. Spotnitz, H. M., E. H. Sonnenblick, and D. Spiro, Relation of Ultrastructure to Function in the Intact Heart: Sarcomere Structure Relative to the Pressure-Volume Curves of the Intact Heart Ventricles of Dog and Cat. Circ. Res. 18, 49 – 66 (1966).

    PubMed  CAS  Google Scholar 

  54. Starling, E. H., The Linacre Lecture on the law of the heart, Given at Cambridge, 1915. 27 pp ( London, Longmans 1918 ).

    Google Scholar 

  55. Streeter, D. D., Jr., H. M. Spotnitz, D. J. Patel, and E. H. Sonnenblick, Fiber Orientation in the Canine Left Ventricle during Diastole and Systole. Circ. Res. 24, 339 – 348 (1969).

    PubMed  Google Scholar 

  56. Streeter, D. D., R. N. Vaishnav, D. J. Patel, H. M. Spotnitz, J. Ross Jr., and E. H. Sonnenblick, Stress Distribution in the Canine Left Ventricle during Diastole and Systole. Biophys. J. 10, 345 – 363 (1970).

    Article  PubMed  Google Scholar 

  57. Suko, J., J. Vogel, and C. Chidsey, Intracellular calcium and myocardial contractility. Ill Reduced calcium uptake and ATPase of Sarcoplasmic reticulum fraction prepared from chronically failing calf hearts. Circ. Res. 27, 235 (1970).

    PubMed  CAS  Google Scholar 

  58. Tybeig, J. V., Parmley, and E. H. Sonnenblick, In Vitro studies of Ventricular Asynchrony and Regional Hypoxia. Circ. Res. 25, 569 – 580 (1969).

    Google Scholar 

  59. Tybeig, J. V., L. Yeatman, W. W. Parmley, and E. H. Sonnenblick, Effects of Hypoxia on the Mechanics of Cardiac Contraction. Amer. J. Physiol. 218, 1780 – 1788 (1970).

    Google Scholar 

  60. Wollenberger, A., W. Kleitke B. & G. Raabe, Some metabolic characteristics of mitochondria from chronically overloaded hypertrophied hearts. Exper. Moleeul. Path. 2, 251 – 260 (1965).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Harvard Medical School, USA

    Dr. med. Edmund H. Sonnenblick (Associate Professor of Medicine, Director)

  2. Cardiovascular Research, Peter Bent Brigham Hospital, Boston, Mass., USA

    Dr. med. Edmund H. Sonnenblick (Associate Professor of Medicine, Director)

  3. Harvard Medical School, USA

    Dr. med. Edward W. Gertz (Instructor of Medicine)

  4. Research Associate Bio Research Institute, USA

    Dr. med. Edward W. Gertz (Instructor of Medicine)

Authors
  1. Dr. med. Edmund H. Sonnenblick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. med. Edward W. Gertz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Bad Nauheim, Germany

    Rudolf Thauer

  2. Giessen, Germany

    Klaus Pleschka

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Dr. Dietrich Steinkopff Verlag, Darmstadt

About this paper

Cite this paper

Sonnenblick, E.H., Gertz, E.W. (1971). Mechanisms of heart failure. In: Thauer, R., Pleschka, K. (eds) Das Gesunde und Kranke Herz bei körperlicher Belastung. Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung, vol 37. Steinkopff. https://doi.org/10.1007/978-3-642-72303-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72303-2_3

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0339-7

  • Online ISBN: 978-3-642-72303-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation