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Part of the book series: Advances in Forensic Haemogenetics ((HAEMOGENETICS,volume 1))

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Abstract

Although it is well known that the HLA system is the single most powerful genetic system commonly used in parentage testing, its efficiency with currently available antisera in excluding a falsely accused man has not been well documented. Various estimates have yielded values which range from 86–96%.1–4 This value will, of course, vary with the number of known alleles, their gene frequencies, the extent of testing, and the criteria used to define the antigens.

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References

  1. Chakravarti A, Li CC. The probability of exclusion based on the HLA locus. Am J Hum Genet 1983; 35: 1048–52.

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  2. Chakravarti A, Li CC. The effect of linkage on paternity calculations. In: Walker RH, ed. Inclusion probabilities in parentage testing. Arlington: Amer. Assoc. of Blood Banks, 1983: 116.

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  5. Standards for Parentage Testing Laboratories. Arlington: Amer. Assoc. of Blood Banks, 1984.

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  6. Lincoln PJ, Dodd BE. An analysis of over 1500 cases of doubtful paternity submitted for blood group investigation (abstract). Transfusion 1979; 19: 663.

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© 1986 Springer-Verlag Berlin Heidelberg

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Walker, R.H., Meyers, M.A., Phillips, L.M. (1986). Probability of Exclusion (PE) of the HLA-A,B System in North American Whites and Blacks. In: Brinkmann, B., Henningsen, K. (eds) 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.). Advances in Forensic Haemogenetics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71150-3_95

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  • DOI: https://doi.org/10.1007/978-3-642-71150-3_95

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16500-2

  • Online ISBN: 978-3-642-71150-3

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