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Clinical Responses in Humans to Rabies Vaccine Prepared in MRC-5 Diploid Cells from Canadian Seed Virus

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Rabies in the Tropics

Summary

Rabies Vaccine prepared in MRC-5 diploid cells from Connaught Laboratories’ virus seed CL-77 was administered to almost 700 adults for primary, reinforcement and post-exposure immunization.

Subjects were immunized using several schedules and results are presented in detail. All subjects responded with acceptable antibody titres. Close monitoring of vaccinees demonstrated a considerable reduction in vaccine side effects with increased purification of the vaccine. No serious side effect occurred in any vaccinee.

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References

  1. Seligmann EB Jr (1973) The NIH test for potency. Laboratory Techniques in Rabies. World Health Organization, Geneva, third Ed, chap 33, pp 279–286

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© 1985 Springer-Verlag Berlin, Heidelberg

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Johnson, S.E., Pearson, E.W., Ing, W.K. (1985). Clinical Responses in Humans to Rabies Vaccine Prepared in MRC-5 Diploid Cells from Canadian Seed Virus. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-70060-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13826-6

  • Online ISBN: 978-3-642-70060-6

  • eBook Packages: Springer Book Archive

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