Abstract
Energy yielding substances (carbohydrates, amino acids, fatty acids) are mainly transferred through the placenta to the fetus. M. YOUNG (25) did a series of animal experiments which showed that the transfer of amino acids from the mother to the fetus was an active transport mechanism depending essentially on the maternal blood flow to the placenta. Fetal malnutrition may result from maternal disease such as hypertension, renal disease, toxemia or vascular insufficiency. (1, 10, 14) that can reduce this flow. Intra-uterine growth retardation follows and is more severe because the disease has occurred very early during pregnancy, and there is often a permanent decrease in cell division and the cellular protein content (24, 23). In serious cases, the brain, though protected for a long time, does not escape.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
BROWNE, J. C. M., VEALL, N.: The maternal placental blood flow in normotensive and hypertensive women. J. Obstet. Gynaec. Brit. Emp. 60, 141–147 (1953).
DUDDENHAUSEN, J.W., KYNAST, G., SALING, E.: Kompensatorische Nutrition des mangelversorgten Feten. 4. Deutscher Kongreß für Perninatale Medizin, Berlin, 4–6, November 1971.
GAUDIER, B., PONTE, C., LACOMBE, A., CALLENS, G., CALLENS, M., Blanc-Garin, A. P.: Etudes des acides aminés sanguins dans le sang du cordon et dans le sang maternel. Ann. Pediat. 19, 277–284 (1972).
HELLER, L.: Arteriovenöse Differenzen im Aminosäurenmuster bei Mutter und Kind. Arch. Gynäk. 211, 304–305 (1971).
HELLER, L.: Intra-uterine Aminoacid feeding of the fetus. IX. International Congress of Nutrition, Mexico-City, 1972.
JANISCH, H., LEODOLTER, S., REINOLD, E.: Der Effekt von Ritodrine auf die Plazentadurchblutung. International symposium on the treatment of fetal risks, Baden, Austria, May 1972 (in press).
KERR, G., KENNAN, A. L.: Free amino-acids of amniotic fluid during pregnancy of the rhesus monkey. Amer. J. Obstet. Gynec. 105, 363–367 (1969).
LINDBLAD, B. S.: The plasma aminogram in “small for dates” newborn infants. In JONXIS, S. H. P. et coll. Metabolic process in the foetus and newborn infant. H. E. Stenfert Kroese, Ed. Leider, 111–126 (1971).
MANZANILLA, S. R., SUAREZ, C. M., CASANOVA, A. N., MAASS, E. R.: Intra-uterine fetal oral feeding: basic research using intra-amniotic albumin I131. VI. World Congress of Gynecology and Obstetrics, New York, 1970. Internat. J. Gynaec. Obstet. 8, 238–239 (1970).
MORRIS, N., OSBORN, S. B., WRIGHT, H. P., HART, A.: Effective uterine blood-flow during excroine in normal and pre-eclamptic pregnancies. Lancet 2, 481–484 (1956).
OSTERGARD, D. R.: The physiology and clinical importance of amniotic fluid. A review. Obstet. Gynec. Surv. 25, 297–319 (1970).
PAGE, E. W.: Discussion in: Pearse, H. W., Sornson, H.: Free amino-acids of normal and abnormal human placenta. Amer. J. Obstet. Gynec. 105, 696–701 (1969).
PEREZ, M. A., ALONSO, J. L., BELITZKY, R.: La puncion amniótica transparietoabdominal (P. A. T.) efectas immediatos sobre la contractilidad uterina y su relación con el comienzo del parto espontâneo. Rev. Argent. Ginec. Obstet. II, 153–159 (1971).
PONTONNIER, G., DELMAS, H., LAGORCE, J. C., JOSSERAND, P.: Mesure du débit placentaire par le Xenon 133 dans la grossesse humaine normale et pathologique. Bull. Fed. Soc. Gynéc. Obstét. lang, franc. 22, 97–127 (1970).
PRITCHARD, J. A.: Deglutition by normal and anencephalic fetuses. Obstet. Gynec. 25, 289–297 (1965).
RENAUD, R., VINCENDON, G., BOOG, G., BRETTES, J. P., KOEHL, C., SCHUMACHER, J. C., KIRSCHTETTER, L., GANDAR, R.: Premiers résultats de perfusions et d’injections d’acides aminés intra-amniotiques dans les malnutritions foetales. lères Journées Nationales de la Société Francaise de Médicine Périnatale, Paris 1971.
RENAUD, R., BOOG, G., BRETTES, J. P., IRRMANN, M., DE MOT, E., SCHUMACHER, J. C., GANDAR, R.: Souffrance foetale — Aspects thérapeutiques. XXIIème Congrès National d’Anesthésie — Réanimation — Paris, 1972; Arnetter éd., Paris, 851–1125, 1972.
RENAUD, R., VINCENDON, G., BOOG, G., BRETTES, J. P., SCHUMACHER, J. C., KOEHL, C., KIRSCHTETTER, L., GANDAR, R.: Injections intra-amniotiques d’acides aminés dans les cas de malnutrition foetale. Premiers résultats. J. Gyn. Obst. Biol. Repr. 1, 231–244 (1972).
RENAUD, R., BRETTES, J. P., IRRMANN, M., BOOG, G., SCHUMACHER, J. C., GANDAR, R.: A double blind cross-over trial to assess the effect of Ritodrine on uterine blood in normal and pathologic pregnancies. International symposium on the treatment of fetal risks, Baden, Austria, May 1972 (in press).
SALING, E., SALCHOW, P., DUDDENHAUSEN, J. W.: Intra-uterine Ernährung des Feten — Erste Untersuchungen. III. Deutscher Kongreß für Perinatale Medizin, Berlin, Stuttgart. Georg Thieme Verlag 1968.
SUGAWA, T., NAKAMURA, K., OZAKI, M.: Studies on the amino-acids and protein metabolism in foetal growth. Dynamics of free amino-acids in the amniotic fluid and its nutritive role in the foetus. J. Jap. Obstet. Gynec. So. 10, 1 (1963).
STURMAN, J. A., GAULL, G., RAIHA, N. C. R.: Absence of Cystathionase in human fetal liver: is cystine essential? Science 169, 74–75 (1970).
WIDDOWSON, E. M.: Protein status of “small for date” animals. In Jonxis, S. H. P. et coll. Metabolic process in the foetus and newborn infant. H. E. Stenfert Kroese, Ed. Leiden, 165–174 (1971).
WINICK, M.: Fetal malnutrition. Klin. Obstet. Gynec. 13, 526–541 (1970).
YOUNG, M.: Placental transport of free amino-acids. In JONXIS, S. H. P. and coll. Metabolic process in the foetus and newborn infant. H. E. STENFERT KROESE, Ed. Leiden, 97–108 (1971).
YOUNG, M., PRENTON, M. A.: Maternal and fetal plasma amino-acid concentrations during gestation and in retarded fetal growth. J. Obstet. Gynaec. Brit. Cwlth. 76, 333–344 (1969).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Renaud, R. et al. (1975). Intra-Amniotic Amino-Acid Injections. In: Salvadori, B. (eds) Therapy of Feto-Placental Insufficiency. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66008-5_56
Download citation
DOI: https://doi.org/10.1007/978-3-642-66008-5_56
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66010-8
Online ISBN: 978-3-642-66008-5
eBook Packages: Springer Book Archive