Skip to main content
SpringerLink
Log in

Zwangs- und Angststörungen

  • Chapter
Funktionelle MRT in Psychiatrie und Neurologie

  • 10k Accesses

Zusammenfassung

Die Anzahl der bildgebenden Studien zu Zwangs- und Angsterkrankungen ist im Laufe der letzten Jahre stetig gewachsen. Da die Zwangssymptomatik mittels Darbietung entsprechender Auslösereize experimentell zuverlässig reproduzierbar ist, wurde in jüngster Zeit immer häufiger der Versuch unternommen, insbesondere den zerebralen Grundlagen der Zwangserkrankung mithilfe bildgebender Verfahren näher zu kommen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adler CM, McDonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM (2000) fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive-compulsive disorder. J Psychiatr Res 34: 317–324

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association (APA) (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th ed, Text Revision (DSM-IV-TR). American Psychiatric Press, Washington

    Google Scholar 

  • An SK, Mataix-Cols D, Lawrence NS, Wooderson S, Giampietro V, Speckens A, Brammer MJ, Phillips ML (2009) To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder. Mol Psychiatry 14: 318–331

    Article  PubMed  CAS  Google Scholar 

  • Baxter LR, Schwartz JM, Mazziotta JC, Phelps ME, Pahl JJ, Guze BH, Fairbanks L (1988) Cerebral glucose metabolic rates in non-depressed obsessive-compulsives. Am J Psychiatry 145: 1560–1563

    PubMed  Google Scholar 

  • Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M, Ng P, Hollon N, Jones M, Blair RJR, Pine DS (2008a) Neural response to self- and other referential praise and criticism in generalized social phobia. Arch Gen Psychiatry 65: 1176–1184

    Article  Google Scholar 

  • Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Mondillo K, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS (2008b) Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 165: 1193–1202

    Article  Google Scholar 

  • Blair K, Geraci M, Hollon N, Otero M, DeVido J, Majestic C, Jacobs M, Blair RJR, Pine DS (2010) Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions. Am J Psychiatry 167: 1526–1532

    Article  PubMed  Google Scholar 

  • Blair K, Geraci M, Korelitz K, Otero M, Towbin K, Ernst M, Leibenluft E, Blair RJR, Pine DS (2011) The pathology of social phobia is independent of devel opmental changes in face processing. Am J Psychiatry 168: 1202–1209

    Article  PubMed  Google Scholar 

  • Brühl AB, Rufer M, Delsignore A, Kaffenberger T, Jäncke L, Herwig U (2011) Neural correlates of altered general emotion processing in social anxiety disorder. Brain Res 1378: 72–83

    Article  PubMed  Google Scholar 

  • Cottraux J, Gerard D, Cinotti L, Froment JC, Deiber MP, Le Bars D, Galy G, Millet P, Labbe C, Lavenne F, Bouvard M, Mauguiere F (1996) A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals. Psychiatry Res 60: 101–112

    Article  PubMed  CAS  Google Scholar 

  • Dilling H, Mombour W, Schmidt MH (2011) Internationale Klassifikation psychischer Störungen. Hans Huber, Bern

    Google Scholar 

  • Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD (2010) Disrupted amygdalar subregion functional connectivity and evidence for a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 167: 545–554

    Google Scholar 

  • Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, Denys D (2011) Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry 69: 867–874

    Article  PubMed  Google Scholar 

  • Fitzgerald KD, Welsh RC, Gehring WJ, Abelson JL, Himle JA, Liberzon I, Taylor SF (2005) Error-related hyperactivity of the anterior cingulated cortex in obsessive-compulsive disorder. Biol Psychiatry 57: 287–294

    Article  PubMed  Google Scholar 

  • Freitas-Ferrari MC, Hallak JEC, Trzesniak C, Filho AS, Machado-de-Sousa JP, Chagas MHN, Nardi AE, Crippa JAS (2010) Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 34: 565–580

    Article  PubMed  Google Scholar 

  • Freyer T, Klöppel S, Tüscher O, Kordon A, Zurowski B, Kuelz A-K, Speck O, Glauche V, Voderholzer U (2011) Frontostriatal activation in patients with obsessive–compulsive disorder before and after cognitive behavioral therapy. Psychol Med 41: 207–216

    Article  PubMed  CAS  Google Scholar 

  • Gu B-M, Park J-Y, Kang D-H, Lee SJ, Yoo SY, Jo HJ, Choi C-H, Lee JM, Kwon JS (2008) Neural correlates of cognitive inflexibility during taskswitching in obsessive-compulsive disorder. Brain 131: 155–164

    Article  PubMed  Google Scholar 

  • Huyser C, Veltman DJ, Wolters LH, de Haan E, Boer F (2011) Developmental aspects of error and high-conflict-related brain activity in pediatric obsessive-compulsive disorder: a fMRI study with a Flanker task before and after CBT. J Child Psychol Psychiatry 52:1251–1260

    Article  PubMed  Google Scholar 

  • Karch S, Pogarell O (2011) Neurobiologie der Zwangsstörung. Nervenarzt 82: 299–307

    Article  PubMed  CAS  Google Scholar 

  • Klumpp H, Angstadta M, Nathan PJ, Phan KL (2010) Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study. Psychiatry Res 183: 167–169

    Article  PubMed  Google Scholar 

  • LeDoux JE (1998) The emotional brain. Simon & Schuster, New York

    Google Scholar 

  • Lorberbaum JP, Kose S, Johnson MR, Arana GW, Sullivan LK, Hamner MB, Ballenger JC, Lydiard RB, Brodrick PS, Bohning DE, George MS (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15: 2701–2705

    PubMed  Google Scholar 

  • Maia TV, Cooney RE, Peterson BS (2008) The neural bases of obsessivecompulsive disorder in children and adults. Dev Psychopathol 20: 1251–1283

    Article  PubMed  Google Scholar 

  • McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ, Fromm S, Charney DS, Leibenluft E, Ernst M, Pine DS (2007) Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry 64: 97–106

    Article  PubMed  Google Scholar 

  • Maltby N, Tolin DF, Worhunsky P, O’Keefe TM, Kiehl KA (2005) Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. NeuroImage 24: 495–503

    Article  PubMed  Google Scholar 

  • Mataix-Cols D, Wooderson S, Lawrence N, Brammer MJ, Speckens A, Phillips ML (2004) Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 61: 564–576

    Article  PubMed  Google Scholar 

  • McGuire PK, Bench CJ, Frith CD, Marks IM, Frackowiak RS, Dolan RJ (1994) Functional anatomy of obsessive-compulsive phenomena. Br J Psychiatry 164: 459–468

    Article  PubMed  CAS  Google Scholar 

  • Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmorea ET (2008) Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofrontostriatal model revisited. Neurosci Biobehav Rev 32: 525–549

    Article  PubMed  Google Scholar 

  • Monk CS, Nelson EE, McClure EB, Mogg K, Bradley BP, Leibenluft E, Blair RJR, Chen G, Charney DS, Ernst M, Pine DS (2006) Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry 163: 1091–1097

    Article  PubMed  Google Scholar 

  • Monk CS, Telzer EH, Mogg K, Bradley BP, Mai X, Louro HM, Chen G, McClure-Tone EB, Ernst M, Pine DS (2008) Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 65: 568–576

    Article  PubMed  Google Scholar 

  • Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ, Kalin NH (2009) Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 166: 302–310

    Article  PubMed  Google Scholar 

  • Nolte J, Angevine JB (2000, 2007) The human brain. Mosby, St. Louis

    Google Scholar 

  • Nordahl TE, Benkelfat C, Semple WE, Gross M, King AC, Cohen RM (1989) Cerebral glucose metabolic rates in obsessive-compulsive disorder. Neuropsychopharmacol 2: 23–28

    Article  CAS  Google Scholar 

  • Page LA, Rubia K, Deeley Q, Daly E, Toald F, Mataix-Colsa D, Giampietro V, Schmitz N, Murphy DGM (2009) A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorder. Psychiatry Res 174: 202–209

    Article  PubMed  Google Scholar 

  • Paulesu E, Sambugaro E, Torti T, Danelli L, Ferri F, Scialfa G, Sberna M, Ruggiero GM, Bottini G, Sassaroli S (2010) Neural correlates of worry in generalized anxiety disorder and in normal controls: a functional MRI study. Psychol Med 40: 117–124

    Article  PubMed  CAS  Google Scholar 

  • Perani D, Colombo C, Bressi S, Bonfanti A, Grassi F, Scarone S, Bellodi L, Smeraldi E, Fazio F (1995) [18F]-FDG PET study in obsessive-compulsive disorder: A clinical/metabolic correlation study after treatment. Br J Psychiatry 166: 244–250

    Article  PubMed  CAS  Google Scholar 

  • Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, Fischman AJ (1994) Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 51: 62–70

    Article  PubMed  CAS  Google Scholar 

  • Rauch SL, Savage CR, Alpert NM, Dougherty D, Kendrick A, Curran T, Brown HD, Manzo P, Fischman AJ, Jenike MA (1997) Probing striatal function in obsessive-compulsive disorder: A PET study of implicit sequence learning. J Neuropsychiatry Clin Neurosci 9: 568–573

    PubMed  CAS  Google Scholar 

  • Rauch SL, Whalen PJ, Curran T, Shin LM, Coffey BI, Savage CR, McInerney SC, Baer L, Jenike MA (2001) Probing striato-thalamic function in obsessive-compulsive disorder and tourette syndrome using neuroimaging methods. Adv Neurol 85: 207–224

    PubMed  CAS  Google Scholar 

  • Remijnse PL, Nielen MMA, van Balkom AJLM, Cath DC, van Oppen P, Uylings HBM, Veltman DJ (2006) Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry 63: 1225–1236

    Article  PubMed  Google Scholar 

  • Remijnse PL, Nielen MMA, van Balkom AJLM, Hendriks GJ, Hoogendijk WJ, Uylings HBM, Veltman DJ (2009) Differential frontal–striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive-compulsive disorder. Psychol Med 39: 1503–1518

    Article  PubMed  CAS  Google Scholar 

  • Rotge J-Y, Guehl D, Dilharreguy B, Cuny E, Tignol J, Bioulac B, Allard M, Burbaud P, Aouizerate B (2008) Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci 33: 405–412

    PubMed  Google Scholar 

  • Sakai Y, Narumoto J, Nishida S, Nakamae T, Yamada K, Nishimura T, Fukui K (2011) Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder. Eur Psychiatry 26: 463–469

    Article  PubMed  CAS  Google Scholar 

  • Sareen J, Campbell DW, Leslie WD, Malisza KL, Stein MB, Paulus MP, Kravetsky LB, Kjernisted KD, Walker JR, Reiss JP (2007) Striatal function in generalized social phobia: a functional Magnetic Resonance Imaging Study. Biol Psychiatry 61: 396–404

    Article  PubMed  Google Scholar 

  • Saxena S, Bota RG, Brody AL (2001) Brain-behavior relationships in obsessive-compulsive disorder. Sem Clin Neuropsychiatry 6: 82–101

    Article  CAS  Google Scholar 

  • Schiepek G, Tominschek I, Karch S, Mulert C, Pogarell O (2007) Neurobiologische Korrelate der Zwangsstörungen – Aktuelle Befunde zur funktionellen Bildgebung. Neuroimaging and the neurobiology of obsessive-compulsive disorder. Psychother Psych Med 57: 379–394

    Article  Google Scholar 

  • Schlösser RGM, Wagner G, Schachtzabel C, Peikert G, Koch K, Reichenbach JR, Sauer H (2010) Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp 31: 1834–1850

    Article  PubMed  Google Scholar 

  • Schmidt S, Mohr A, Miltner WHR, Straube T (2010) Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. Biol Psychol 84: 304–312

    Article  PubMed  Google Scholar 

  • Schneider F, Weiss U, Kessler C, Müller-Gürtner HW, Posse S, Sallo JB, Grodd W, Himmelmann F, Gaebel W, Birbaumer N (1999) Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry 45: 863–871

    Article  PubMed  CAS  Google Scholar 

  • Shallice T (1982) Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 298: 199–209

    Article  PubMed  CAS  Google Scholar 

  • Shapira NA, Liu Y, He AG, Bradley MM, Lessing MC, James GA, Stein DJ, Lang PJ, Goodman PK (2003) Brain activation by disgust-inducing in obsessive-compulsive disorder. Biol Psychiatry 54: 751–756

    Article  PubMed  Google Scholar 

  • Simon D, Kaufmann C, Müsch K, Kischel E, Kathmann N (2010) Frontostriato-limbic hyperactivation in obsessive compulsive disorder during individually tailored symptom provocation. Psychophysiology 47: 728–738

    PubMed  Google Scholar 

  • Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG (2002) Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 59: 1027–1034

    Article  PubMed  Google Scholar 

  • Straube T, Kolassa IT, Glauer M, Mentzel HJ, Miltner WH (2004) Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biol Psychiatry 56: 921–930

    Article  PubMed  Google Scholar 

  • Swedo SE, Schapiro MG, Grady CL, Cheslow DL, Leonard HL, Kumar A, Friedland R, Rapoport SI, Rapoport JL (1989) Cerebral glucose metabolism in childhood onset obsessive-compulsive disorder. Arch Gen Psychiatry 46: 518–523

    Article  PubMed  CAS  Google Scholar 

  • Taylor SF, Welsh RC, Fitzgerald KD, Himle JA, Gehring WJ, Abelson JL, Liberzon I (2003) Evaluation of anterior cingulate dysfunction in obsessive compulsive disorder during cognitive conflict. Neuro-Image 19 (Suppl 1): S633

    Google Scholar 

  • Ursu S, Stenger VA, Shear MK, Jones MR, Carter CS (2003) Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychol Sci 14: 347–353

    Article  PubMed  Google Scholar 

  • Van Den Heuvel OA, Veltman DJ, Groenewegen HJ, Barkhof F, Cath DC, van Balkom AJLM, van Oppen P, Hartskamp van J, Dyck van R (2003) Frontal-striatal dysfunction during planning in obsessivecompulsive disorder. NeuroImage 19 (Suppl 1): S635

    Google Scholar 

  • Van Den Heuvel OA, Veltman DJ, Groenewegen HJ, Cath DC, van Balkom AJ, van Hartskamp J, Barkhof F, van Dyck R (2005) Frontalstriatal dysfunction during planning in obsessive-compulsive disorder. Arch Gen Psychiatry 62: 301–309

    Article  PubMed  Google Scholar 

  • Veit R, Flor H, Erb M, Hermann C, Lotze M, Grodd W, Birbaumer N (2002) Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 328: 233–236

    Article  PubMed  CAS  Google Scholar 

  • Whalen PJ, Johnstone T, Somerville LH, Nitschke JB, Polis S, Alexander AL, Davidson RJ, Kalin NH (2007) A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biol Psychiatry 63: 858–863

    Article  PubMed  Google Scholar 

  • Whalen PJ, Johnstone T, Somerville LH, Nitschke JB, Polis S, Ihde-Scholl T, Tarleton L, Alexander AL, Davidson RJ, Kalin NH (2008) A functional MRI predictor of treatment response to venlafaxine in generalized anxiety disorder. Biol Psychiatry 63: 858–863

    Article  PubMed  CAS  Google Scholar 

  • Whiteside SP, Port JD, Abramowitz JS (2004) A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res 132: 69–79

    Article  PubMed  Google Scholar 

  • Yoon KL, Fitzgerald DA, Angstadt M, McCarron RA, Phan KL (2007) Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Res 154: 93–98

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für diagnostische und interventionelle Neuroradiologie Klinikum Rechts der Isar, TU München, Ismaninger Straße 22, 81675, München

    PD Dr. Kathrin Koch

  2. Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen

    Prof. Dr. Dr. Klaus Mathiak

Authors
  1. PD Dr. Kathrin Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. Dr. Klaus Mathiak
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinikum Aachen, Aachen

    Frank Schneider

  2. Forschungszentrum Jülich, Jülich

    Gereon R. Fink

  3. Uniklinik Köln, Köln

    Gereon R. Fink

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Koch, K., Mathiak, K. (2013). Zwangs- und Angststörungen. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29800-4_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-29800-4_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29799-1

  • Online ISBN: 978-3-642-29800-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation