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46,XX Disorders of Sex Development

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Disorders of Sex Development

Abstract

46,XX DSD comprise the most common group of genital abnormalities, with congenital adrenal hyperplasia (CAH) being the most important, not only because of its frequency but also because of its life-threatening complications without treatment. The different disorders are described, showing the range of genetic and enzymatic anomalies that lead to excess androgen production causing abnormal virilisation of a female foetus. The non-hormonal anatomical defects of genital development are also mentioned.

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Authors and Affiliations

  1. Department of Endocrinology and Diabetes, Royal Children’s Hospital Melbourne, Parkville, VIC, Australia

    Garry L. Warne & Jacqueline K. Hewitt

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  1. Garry L. Warne
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  2. Jacqueline K. Hewitt
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Correspondence to Garry L. Warne .

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Editors and Affiliations

  1. , Department of Urology, The Royal Children's Hospital, Flemington Road, Parkville, 3052, Victoria, Australia

    John M. Hutson

  2. , Department of Endocrinology and Diabetes, The Royal Children's Hospital, Flemington Road, Parkville, 3052, Victoria, Australia

    Garry L. Warne

  3. , Department of Gynaecology, Royal Children's Hospital, Flemington Road, Parkville, 3052, Victoria, Australia

    Sonia R. Grover

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Warne, G.L., Hewitt, J.K. (2012). 46,XX Disorders of Sex Development. In: Hutson, J., Warne, G., Grover, S. (eds) Disorders of Sex Development. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22964-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-22964-0_6

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