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The Role of Estrogens and Estrogenic Metabolites and Male Reproductive Health Disorders

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Implications and Consequences of Anthropogenic Pollution in Polar Environments

Part of the book series: From Pole to Pole ((POLE))

Abstract

In the past five decades or so, there has been an explosion of chemical compounds that has entered the market for use in industry, trade, and commerce. The chemical compounds have also permeated household cleaning and other products and also personal care products. It is believed that currently about 400 million tons of chemicals are used in commerce in the European Union for industrial, household and personal care products. Endocrine-disrupting chemicals (EDCs) are synthetic chemicals which can interfere with endogenous sex hormone function leading to a range of developmental and reproductive anomalies. The exposure to EDC is ubiquitous because of the use of these substances in commerce, trade, household products, and personal care products and in food processing and packing. EDCs are used in pharmaceuticals, in agriculture as pesticides, in industry as additives and for their specific activities, in household and personal care products for their antibacterial and antiseptic properties, and in commerce for packaging food and as food items as in natural products (soy). This review examines the exposure to EDC among the males during embryonic and postnatal development. The impacts of exposures during different phases of life on the male reproductive health during embryonic development, adolescence, and adult life have also been explored. Human exposure to EDCs occurs through different routes including inhalation, gastric, dermal, and use of personal products; however, the biggest source of exposure is dietary for all ages. Gestational exposure occurs from maternal exposure during pregnancy, infants are exposed through milk ingestion, and adults are exposed through consumption of phytoestrogens. A range of adverse health observed in males exposed to EDC at different points in time is reported to be associated with exposure.

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Abbreviations

AR:

Androgen receptor

BPA:

Bisphenol A

cAMP:

Cyclic adenosine 3′ 5′-monophosphate

DAX1:

Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1

DDE:

Dichlorodiphenyldichloroethylene

DDT:

Dichlorodiphenyltrichloroethane

DEHP:

Diethylhexyl phthalate

DES:

Diethylstilbestrol

DNA:

Deoxyribonucleic acid

EDs:

Endocrine disruptors

EDCs:

Endocrine-disrupting chemicals

ER:

Estrogen receptor

ERα:

Estrogen receptor alpha

ERβ:

Estrogen receptor beta

FSH:

Follicle-stimulating hormone

HPTE:

2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane

LH:

Luteinizing hormone

PCBs:

Polychlorinated biphenyls

PCDF:

Polychlorinated dibenzofuran

PR:

Progestin receptor

RNA:

Ribonucleic acid

SF1:

Steroidogenic factor 1

StAR:

Steroidogenic acute regulatory protein

TDS:

Testicular dysgenesis syndrome

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Authors and Affiliations

  1. Faculty of Health Sciences, Interdisciplinary School of Health Sciences, Ottawa, Canada

    James Gomes & G. Roche

  2. McLaughlin Center for Population Health Risk Assessment, Ottawa, Canada

    James Gomes

  3. Environmental Health Research Unit, Faculty of Medicine, 25 University Private, Room THN 210, Ottawa, ON, K1N 6N5, Canada

    James Gomes

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  1. James Gomes
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  2. G. Roche
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Correspondence to James Gomes .

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  1. Dept. of Chemistry, Biotechnology and Food Sciences , Norwegian University of Life Sciences IKBM/VetBio, Ås, Norway

    Roland Kallenborn

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Gomes, J., Roche, G. (2016). The Role of Estrogens and Estrogenic Metabolites and Male Reproductive Health Disorders. In: Kallenborn, R. (eds) Implications and Consequences of Anthropogenic Pollution in Polar Environments. From Pole to Pole. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12315-3_8

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