Skip to main content

Abstract

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Since the time of Ayurveda numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and thus has a potential against various malignant cancers, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Thus, curcumin, by virtue of its effect on multiple cell signaling pathways, could prove to be a panacea for modern human diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Daube FV (1870) Uber Curcumin, den Farbstoff der Curcumawurzel Ber 3:609

    Google Scholar 

  2. Lampe V (1910) Ver Dtsch Chem Ger 43:2163

    Article  Google Scholar 

  3. Lampe V Milobedzka J (1913) Ver DtschChem Ges 46:2235

    CAS  Google Scholar 

  4. Srinivasan KR (1952) Curr Sci 21:311

    CAS  Google Scholar 

  5. Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y (1993) Chem Pharm Bull (Tokyo) 41:1640

    CAS  Google Scholar 

  6. Prasad NS (1997) Indian Drugs 34:227

    Google Scholar 

  7. Chignell CF, Bilski P, Reszka KJ, Motten AG, Sik RH, Dahl TA (1994) Photochem Photobiol 59:295

    Article  CAS  Google Scholar 

  8. Sharma OP (1976) Biochem Pharmacol 25:1811

    Article  CAS  Google Scholar 

  9. Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R (1995) Cancer Lett 94:79

    Article  CAS  Google Scholar 

  10. Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M (2005) Anticancer Drugs 16:263

    Article  CAS  Google Scholar 

  11. Khopde SM, Priyadarsini KI, Venkatesan N, Rao MNA (1999) Biophys Chem 80:83

    Article  Google Scholar 

  12. Motterlini R, Foresti R, Bassi R, Green CJ (2000) Free Radic Biol Med 28:1303

    Article  CAS  Google Scholar 

  13. Shishodia S, Chaturvedi MM, Aggarwal BB (2007) Curr Prob Cancer 31:243–305.

    Article  Google Scholar 

  14. Jagetia GC, Aggarwal BB (2007) J Clin Immunol 27:19

    Article  CAS  Google Scholar 

  15. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, S Stuart G, Udove J, Ullrich A, et al. (1989) Science 244:707

    Article  CAS  Google Scholar 

  16. Korutla L, Cheung JY, Mendelsohn J, Kumar R (1995) Carcinogenesis 16:1741

    Article  CAS  Google Scholar 

  17. Korutla L, Kumar R (1994) Biochim Biophys Acta 1224:597

    Article  Google Scholar 

  18. Hong RL, Spohn WH, Hung MC (1999) Clin Cancer Res 5:1884

    CAS  Google Scholar 

  19. Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007) Adv Exp Med Biol 595:1

    Article  Google Scholar 

  20. Bharti AC, Donato N, BB Aggarwal (2003) J Immunol 171:3863

    CAS  Google Scholar 

  21. Xu J, Fu Y, Chen A (2003) Am J Physiol Gastrointest Liver Physiol 285:G20

    CAS  Google Scholar 

  22. Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L (1999) Oncogene 18:6013

    Article  CAS  Google Scholar 

  23. Chen H, Zhang ZS, Zhang YL, Zhou DY (1999) Anticancer Res 19:3675

    CAS  Google Scholar 

  24. Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ (2003) Carcinogenesis 24:1515

    Article  CAS  Google Scholar 

  25. Plummer SM, Hill KA, Festing MF, Steward WP, Gescher AJ, Sharma RA (2001) Cancer Epidemiol Biomarkers Prev 10:1295

    CAS  Google Scholar 

  26. Reddy S, Aggarwal BB (1994) FEBS Lett 341:19

    Article  CAS  Google Scholar 

  27. Liu JY, Lin SJ, Lin JK 919930 Carcinogenesis 14:857

    Google Scholar 

  28. Hasmeda M, Polya GM (1996) Phytochemistry 42:599

    Article  CAS  Google Scholar 

  29. Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB (2002) C Oncogene 21:8852

    Article  CAS  Google Scholar 

  30. Ohene-Abuakwa Y, Noda M, Perenyi M, Kobayashi N, Kashima K, Hattori T, Pignatelli M (2000) J Pathol 192:433

    Article  CAS  Google Scholar 

  31. Iademarco MF, Barks JL, Dean DC (1995) J Clin Invest 95:264

    Article  CAS  Google Scholar 

  32. Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB (1998) Biochem Pharmacol 55:775

    Article  CAS  Google Scholar 

  33. Gupta B, Ghosh B (1999) Int J Immunopharmacol 21:745

    Article  CAS  Google Scholar 

  34. Jaiswal AS, Marlow BP, Gupta N, Narayan S (2002) Oncogene 21:8414

    Article  CAS  Google Scholar 

  35. Anto RJ, Mukhopadhyay A, Denning K, Aggarwal BB (2002) Carcinogenesis 23:143

    Article  CAS  Google Scholar 

  36. Shishodia S, Amin HM, Lai R, Aggarwal BB (2005) Biochem Pharmacol 70:700

    Article  CAS  Google Scholar 

  37. Bharti AC, Donato N, Singh S, Aggarwal BB (2003) Blood 101:1053

    Article  CAS  Google Scholar 

  38. Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV, PN Limtrakul (2002) Biochem Pharmacol 64:573

    Article  CAS  Google Scholar 

  39. Limtrakul P, Anuchapreeda S, Buddhasukh D (2004) BMC Cancer 4:13

    Article  Google Scholar 

  40. Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer Res 23:363

    CAS  Google Scholar 

  41. Kuo ML, Huang TS, Lin JK (1996) Biochim Biophys Acta 1317:95

    CAS  Google Scholar 

  42. Ranjan D, Johnston TD, Reddy KS, Wu G, Bondada S, Chen C (1999) J Surg Res 87:1

    Article  CAS  Google Scholar 

  43. Piwocka K, Zablocki K, Wieckowski MR, Skierski J, Feiga I, Szopa J, Drela N, Wojtczak L, Sikora E (1999) Exp Cell Res 249:299

    Article  CAS  Google Scholar 

  44. Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S (1999) Clin Immunol 93:152

    Article  CAS  Google Scholar 

  45. Chen A, Davis BH, Bissonnette M, Scaglione-Sewell B, Brasitus TA (1999) J Biol Chem 274:35505

    Article  CAS  Google Scholar 

  46. Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB (2004) Int J Cancer 111:679

    Article  CAS  Google Scholar 

  47. Mehta K, Pantazis P, McQueen T, Aggarwal BB (1997) Anticancer Drugs 8:470

    Article  CAS  Google Scholar 

  48. Ramachandran C, You W (1999) Breast Cancer Res Treat 54:269

    Article  CAS  Google Scholar 

  49. Simon A, Allais DP, Duroux JL, Basly JP, Durand-Fontanier S, Delage C (1998) Cancer Lett 129:111

    Article  CAS  Google Scholar 

  50. Fang J, Lu J, Holmgren A (2005) J Biol Chem 280:25284

    Article  CAS  Google Scholar 

  51. Kang J, Chen J, Shi Y, Jia J, Zhang Y (2005) Biochem Pharmacol 69:1205

    Article  CAS  Google Scholar 

  52. Prusty BK, Das BC (2005) Int J Cancer 113:951

    Article  CAS  Google Scholar 

  53. Sen S, Sharma H, Singh N (2005) Biochem Biophys Res Commun 331:1245

    Article  CAS  Google Scholar 

  54. Koo JY, Kim HJ, Jung KO, Park KY (2004) J Med Food 7:117

    Article  CAS  Google Scholar 

  55. Holy J (2004) Cell Motil Cytoskeleton 58:253

    Article  CAS  Google Scholar 

  56. Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB (2004) Blood 103:3175

    Article  CAS  Google Scholar 

  57. Mahady GB, Pendland SL, Yun G, Lu ZZ (2002) Anticancer Res 22:4179

    CAS  Google Scholar 

  58. Chen HW, Yu SL, Chen JJ, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, Yang PC (2004) Mol Pharmacol 65:99

    Article  CAS  Google Scholar 

  59. Kim JH, Shim JS, Lee SK, Kim KW, Rha SY, Chung HC, Kwon HJ (2002) Jpn J Cancer Res 93:1378

    CAS  Google Scholar 

  60. Kuttan R, Bhanumathy P, Nirmala K, George MC (1985) Cancer Lett 29:197

    Article  CAS  Google Scholar 

  61. Busquets S, Carbo N, Almendro V, Quiles MT, Lopez-Soriano FJ, Argiles JM (2001) Cancer Lett 167:33

    Article  CAS  Google Scholar 

  62. Menon LG, Kuttan R, Kuttan G (1995) Cancer Lett 95:221

    Article  CAS  Google Scholar 

  63. Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE (2001) Prostate 47:293

    Article  CAS  Google Scholar 

  64. Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS (1999) Cancer Res 59:597

    CAS  Google Scholar 

  65. Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, Williams ML, Steward WP, Gescher AJ (2002) Cancer Epidemiol Biomarkers Prev 11:535–540.

    CAS  Google Scholar 

  66. Odot J, Albert P, Carlier A, Tarpin M, Devy J, Madoulet C (2004) Int J Cancer 111:381

    Article  CAS  Google Scholar 

  67. Thangapazham RL, Sharma A, Maheshwari RK (2007) Adv Exp Med Biol 595:343

    Article  Google Scholar 

  68. Heng MC, Song MK, Harker J, Heng MK (2000) Br J Dermatol 143:937

    Article  CAS  Google Scholar 

  69. Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley A, Silver RM, Hoffman S (2004) Am J Respir Cell Mol Biol 31:28

    Article  CAS  Google Scholar 

  70. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, Maheshwari RK (1998) Wound Repair Regen 6:167

    Article  CAS  Google Scholar 

  71. Phan TT, Sun L, Bay BH, Chan SY, Lee ST (2003) J Trauma 54:1212

    CAS  Google Scholar 

  72. Deodhar SD, Sethi R, Srimal RC (1980) Indian J Med Res 71:632

    CAS  Google Scholar 

  73. Liacini A, Sylvester J, Li WQ, Zafarullah M (2002) Matrix Biol 21:251

    Article  CAS  Google Scholar 

  74. Natarajan C, Bright JJ (2002) J Immunol 168:6506

    CAS  Google Scholar 

  75. Verbeek R, van Tol EA, van Noort JM (2005) Biochem Pharmacol 70:220

    Article  CAS  Google Scholar 

  76. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM (2005) J Biol Chem 280:5892

    Article  CAS  Google Scholar 

  77. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) J Neurosci 21:8370

    CAS  Google Scholar 

  78. Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK (2003) Br J Pharmacol 139:209

    Article  CAS  Google Scholar 

  79. Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K (2003) Am J Physiol Gastrointest Liver Physiol 285:G235

    CAS  Google Scholar 

  80. Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ (2004) Science 304:600

    Article  CAS  Google Scholar 

  81. Berger AL, Randak CO, Ostedgaard LS, Karp PH, Vermeer DW, Welsh MJ (2005) J Biol Chem 280:5221

    Article  CAS  Google Scholar 

  82. Shishodia S, Sethi G, Aggarwal BB (2005) Ann N Y Acad Sci 1056:206

    Article  CAS  Google Scholar 

  83. Venkatesan P, Rao MN (2000) J Pharm Pharmacol 52:1123

    Article  CAS  Google Scholar 

  84. Sreejayan N, Rao MN (1996) Arzneimittelforschung 46:169

    CAS  Google Scholar 

  85. Ahsan H, Parveen N, Khan NU, Hadi SM (1999) Chem Biol Interact 121:161

    Article  CAS  Google Scholar 

  86. Dinkova-Kostova AT, Talalay P (1999) Carcinogenesis 20:911

    Article  CAS  Google Scholar 

  87. Kawashima H, Akimoto K, Jareonkitmongkol S, Shirasaka N, Shimizu S (1996) Biosci Biotechnol Biochem 60:108

    Article  CAS  Google Scholar 

  88. Robinson TP, Ehlers T, Hubbard IR, Bai X, Arbiser JL, Goldsmith DJ, Bowen JP (2003) Bioorg Med Chem Lett 13:115

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sethi, G., Sung, B., Aggarwal, B.B. (2009). The Role of Curcumin in Modern Medicine. In: Ramawat, K. (eds) Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79116-4_7

Download citation

Publish with us

Policies and ethics