Abstract
Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Since the time of Ayurveda numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and thus has a potential against various malignant cancers, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Thus, curcumin, by virtue of its effect on multiple cell signaling pathways, could prove to be a panacea for modern human diseases.
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References
Daube FV (1870) Uber Curcumin, den Farbstoff der Curcumawurzel Ber 3:609
Lampe V (1910) Ver Dtsch Chem Ger 43:2163
Lampe V Milobedzka J (1913) Ver DtschChem Ges 46:2235
Srinivasan KR (1952) Curr Sci 21:311
Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y (1993) Chem Pharm Bull (Tokyo) 41:1640
Prasad NS (1997) Indian Drugs 34:227
Chignell CF, Bilski P, Reszka KJ, Motten AG, Sik RH, Dahl TA (1994) Photochem Photobiol 59:295
Sharma OP (1976) Biochem Pharmacol 25:1811
Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R (1995) Cancer Lett 94:79
Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M (2005) Anticancer Drugs 16:263
Khopde SM, Priyadarsini KI, Venkatesan N, Rao MNA (1999) Biophys Chem 80:83
Motterlini R, Foresti R, Bassi R, Green CJ (2000) Free Radic Biol Med 28:1303
Shishodia S, Chaturvedi MM, Aggarwal BB (2007) Curr Prob Cancer 31:243–305.
Jagetia GC, Aggarwal BB (2007) J Clin Immunol 27:19
Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, S Stuart G, Udove J, Ullrich A, et al. (1989) Science 244:707
Korutla L, Cheung JY, Mendelsohn J, Kumar R (1995) Carcinogenesis 16:1741
Korutla L, Kumar R (1994) Biochim Biophys Acta 1224:597
Hong RL, Spohn WH, Hung MC (1999) Clin Cancer Res 5:1884
Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007) Adv Exp Med Biol 595:1
Bharti AC, Donato N, BB Aggarwal (2003) J Immunol 171:3863
Xu J, Fu Y, Chen A (2003) Am J Physiol Gastrointest Liver Physiol 285:G20
Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L (1999) Oncogene 18:6013
Chen H, Zhang ZS, Zhang YL, Zhou DY (1999) Anticancer Res 19:3675
Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ (2003) Carcinogenesis 24:1515
Plummer SM, Hill KA, Festing MF, Steward WP, Gescher AJ, Sharma RA (2001) Cancer Epidemiol Biomarkers Prev 10:1295
Reddy S, Aggarwal BB (1994) FEBS Lett 341:19
Liu JY, Lin SJ, Lin JK 919930 Carcinogenesis 14:857
Hasmeda M, Polya GM (1996) Phytochemistry 42:599
Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB (2002) C Oncogene 21:8852
Ohene-Abuakwa Y, Noda M, Perenyi M, Kobayashi N, Kashima K, Hattori T, Pignatelli M (2000) J Pathol 192:433
Iademarco MF, Barks JL, Dean DC (1995) J Clin Invest 95:264
Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB (1998) Biochem Pharmacol 55:775
Gupta B, Ghosh B (1999) Int J Immunopharmacol 21:745
Jaiswal AS, Marlow BP, Gupta N, Narayan S (2002) Oncogene 21:8414
Anto RJ, Mukhopadhyay A, Denning K, Aggarwal BB (2002) Carcinogenesis 23:143
Shishodia S, Amin HM, Lai R, Aggarwal BB (2005) Biochem Pharmacol 70:700
Bharti AC, Donato N, Singh S, Aggarwal BB (2003) Blood 101:1053
Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV, PN Limtrakul (2002) Biochem Pharmacol 64:573
Limtrakul P, Anuchapreeda S, Buddhasukh D (2004) BMC Cancer 4:13
Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer Res 23:363
Kuo ML, Huang TS, Lin JK (1996) Biochim Biophys Acta 1317:95
Ranjan D, Johnston TD, Reddy KS, Wu G, Bondada S, Chen C (1999) J Surg Res 87:1
Piwocka K, Zablocki K, Wieckowski MR, Skierski J, Feiga I, Szopa J, Drela N, Wojtczak L, Sikora E (1999) Exp Cell Res 249:299
Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S (1999) Clin Immunol 93:152
Chen A, Davis BH, Bissonnette M, Scaglione-Sewell B, Brasitus TA (1999) J Biol Chem 274:35505
Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB (2004) Int J Cancer 111:679
Mehta K, Pantazis P, McQueen T, Aggarwal BB (1997) Anticancer Drugs 8:470
Ramachandran C, You W (1999) Breast Cancer Res Treat 54:269
Simon A, Allais DP, Duroux JL, Basly JP, Durand-Fontanier S, Delage C (1998) Cancer Lett 129:111
Fang J, Lu J, Holmgren A (2005) J Biol Chem 280:25284
Kang J, Chen J, Shi Y, Jia J, Zhang Y (2005) Biochem Pharmacol 69:1205
Prusty BK, Das BC (2005) Int J Cancer 113:951
Sen S, Sharma H, Singh N (2005) Biochem Biophys Res Commun 331:1245
Koo JY, Kim HJ, Jung KO, Park KY (2004) J Med Food 7:117
Holy J (2004) Cell Motil Cytoskeleton 58:253
Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB (2004) Blood 103:3175
Mahady GB, Pendland SL, Yun G, Lu ZZ (2002) Anticancer Res 22:4179
Chen HW, Yu SL, Chen JJ, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, Yang PC (2004) Mol Pharmacol 65:99
Kim JH, Shim JS, Lee SK, Kim KW, Rha SY, Chung HC, Kwon HJ (2002) Jpn J Cancer Res 93:1378
Kuttan R, Bhanumathy P, Nirmala K, George MC (1985) Cancer Lett 29:197
Busquets S, Carbo N, Almendro V, Quiles MT, Lopez-Soriano FJ, Argiles JM (2001) Cancer Lett 167:33
Menon LG, Kuttan R, Kuttan G (1995) Cancer Lett 95:221
Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE (2001) Prostate 47:293
Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS (1999) Cancer Res 59:597
Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, Williams ML, Steward WP, Gescher AJ (2002) Cancer Epidemiol Biomarkers Prev 11:535–540.
Odot J, Albert P, Carlier A, Tarpin M, Devy J, Madoulet C (2004) Int J Cancer 111:381
Thangapazham RL, Sharma A, Maheshwari RK (2007) Adv Exp Med Biol 595:343
Heng MC, Song MK, Harker J, Heng MK (2000) Br J Dermatol 143:937
Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley A, Silver RM, Hoffman S (2004) Am J Respir Cell Mol Biol 31:28
Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, Maheshwari RK (1998) Wound Repair Regen 6:167
Phan TT, Sun L, Bay BH, Chan SY, Lee ST (2003) J Trauma 54:1212
Deodhar SD, Sethi R, Srimal RC (1980) Indian J Med Res 71:632
Liacini A, Sylvester J, Li WQ, Zafarullah M (2002) Matrix Biol 21:251
Natarajan C, Bright JJ (2002) J Immunol 168:6506
Verbeek R, van Tol EA, van Noort JM (2005) Biochem Pharmacol 70:220
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM (2005) J Biol Chem 280:5892
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) J Neurosci 21:8370
Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK (2003) Br J Pharmacol 139:209
Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K (2003) Am J Physiol Gastrointest Liver Physiol 285:G235
Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ (2004) Science 304:600
Berger AL, Randak CO, Ostedgaard LS, Karp PH, Vermeer DW, Welsh MJ (2005) J Biol Chem 280:5221
Shishodia S, Sethi G, Aggarwal BB (2005) Ann N Y Acad Sci 1056:206
Venkatesan P, Rao MN (2000) J Pharm Pharmacol 52:1123
Sreejayan N, Rao MN (1996) Arzneimittelforschung 46:169
Ahsan H, Parveen N, Khan NU, Hadi SM (1999) Chem Biol Interact 121:161
Dinkova-Kostova AT, Talalay P (1999) Carcinogenesis 20:911
Kawashima H, Akimoto K, Jareonkitmongkol S, Shirasaka N, Shimizu S (1996) Biosci Biotechnol Biochem 60:108
Robinson TP, Ehlers T, Hubbard IR, Bai X, Arbiser JL, Goldsmith DJ, Bowen JP (2003) Bioorg Med Chem Lett 13:115
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Sethi, G., Sung, B., Aggarwal, B.B. (2009). The Role of Curcumin in Modern Medicine. In: Ramawat, K. (eds) Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79116-4_7
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DOI: https://doi.org/10.1007/978-3-540-79116-4_7
Publisher Name: Springer, Berlin, Heidelberg
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