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None in common usage
Definition and Characteristics
Symmetrical inflammatory arthropathy, incident across a broad age range (median onset sixth decade), characterized by articular pain, stiffness (especially in the morning), swelling and loss of function. Onset can be in any diarthrodial joint, but distribution typically includes metacarpal and proximal interphalangeal (IP) joints of hand, metatarsal and IP joints of the foot, knee, hip and shoulder joints, and axial skeleton, particularly cervical spine. Synovial inflammation is associated with progressive cartilage and bone erosion, consequent deformity and accelerated functional decline. Extra-articular clinical features include scleritis, uveitis, pulmonary nodule formation (rarely bronchiolitis), neuropathy, small vessel vasculitis, and extensor surface nodule formation. Accelerated atherogenesis and cardiac failure account for reduced life expectancy (3–15 years). Rapid functional impairment, socio-economic decline,...
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References
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© 2009 Springer-Verlag GmbH Berlin Heidelberg
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McInnes, I.B. (2009). Rheumatoid Arthritis. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_1563
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DOI: https://doi.org/10.1007/978-3-540-29676-8_1563
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
Online ISBN: 978-3-540-29676-8
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