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Genetics of Hypertension and Heart Failure

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Hypertension and Heart Failure

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Hypertension and heart failure are leading causes of death and disability worldwide. Both are complex multifactorial conditions with hypertension and heart failure at either ends of the cardiovascular continuum. Rare mutations resulting in monogenic forms of hypertension, hypotension and cardiomyopathies highlight the importance of genetics in disease causation and consequent implications for disease prediction and treatment. Advances in genomics have accelerated over the last decade leading to an unparalleled leap in our understanding of the genetic architecture of both hypertension and heart failure. In this chapter, we describe the current state of the art in the genetics of both conditions, hypertension and heart failure, focussing on biologic pathways that are perturbed and opportunities for early detection and treatment.

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Author information

Authors and Affiliations

  1. Institute of Cardiovascular and Medical Sciences, Glasgow, UK

    Sandosh Padmanabhan, Alisha Aman & Anna F. Dominiczak

  2. College of Medical, Veterinary and Life Sciences, University of Glasgow, Wolfson Medical School Building, Glasgow, UK

    Anna F. Dominiczak

Authors
  1. Sandosh Padmanabhan
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  2. Alisha Aman
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  3. Anna F. Dominiczak
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Corresponding author

Correspondence to Anna F. Dominiczak .

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Editors and Affiliations

  1. Carol Davila University of Medicine and Pharmacy Bucharest and Cardiology Department, Emergency Clinical Hospital, Bucharest, Romania

    Maria Dorobantu

  2. University of Milano-Bicocca, Milano, Italy

    Giuseppe Mancia  & Guido Grassi  & 

  3. Department of Pharmacology, Toxicology and Clinical Psychopharmacology Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Victor Voicu

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Padmanabhan, S., Aman, A., Dominiczak, A.F. (2019). Genetics of Hypertension and Heart Failure. In: Dorobantu, M., Mancia, G., Grassi, G., Voicu, V. (eds) Hypertension and Heart Failure. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-93320-7_2

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  • DOI: https://doi.org/10.1007/978-3-319-93320-7_2

  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-93320-7

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