Historical Background
Toll-like receptors (TLRs) are expressed in immune cells such as dendritic cells and macrophages and recognize pathogens (Takeda and Akira 2005). Along with four other TLRs, human TLR2 was first named and reported as a receptor similar to the Drosophila Toll protein in 1998 (Rock et al. 1998). TLR2 gene, with a size of 21,836 bases on chromosome 4, encodes the TLR2 protein. TLR2 is one of the pattern recognition receptors (PRRs) that sense pathogen-associated molecular patterns (PAMPs) of microbes and thus act as a first line of host defense (Janeway and Medzhitov 2002). The triggering of an innate immune response by PRRs after recognition of conserved microbial components and further development of the adaptive immunity were first described by Charles A. Janeway Jr. (Janeway 1989). The initial understanding of the TLR2 ligand was obtained in 1999 when a study revealed that...
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References
Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, et al. Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv. 2012;5:279–87. https://doi.org/10.1161/CIRCINTERVENTIONS.111.967596.
Bauernfeind F, Hornung V. TLR2 joins the interferon gang. Nat Immunol. 2009;10:1139–41. https://doi.org/10.1038/ni1109-1139.
Botos I, Segal DM, Davies DR. The structural biology of Toll-like receptors. Structure. 2011;19:447–59. https://doi.org/10.1016/j.str.2011.02.004.
Gay NJ, Symmons MF, Gangloff M, Bryant CE. Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol. 2014;14:546–58. https://doi.org/10.1038/nri3713.
Janeway Jr CA. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol. 1989;54(Pt 1):1–13.
Janeway Jr CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197–216. https://doi.org/10.1146/annurev.immunol.20.083001.084359.
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071–82. https://doi.org/10.1016/j.cell.2007.09.008.
Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009;31:873–84. https://doi.org/10.1016/j.immuni.2009.09.018.
Keogh B, Parker AE. Toll-like receptors as targets for immune disorders. Trends Pharmacol Sci. 2011;32:435–42. https://doi.org/10.1016/j.tips.2011.03.008.
Kondo T, Kawai T, Akira S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 2012;33:449–58. https://doi.org/10.1016/j.it.2012.05.002.
Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol. 2012;12:168–79. https://doi.org/10.1038/nri3151.
Lima CX, Souza DG, Amaral FA, Fagundes CT, Rodrigues IP, Alves-Filho JC, et al. Therapeutic effects of treatment with anti-TLR2 and anti-TLR4 monoclonal antibodies in polymicrobial sepsis. PLoS One. 2015;10:e0132336. https://doi.org/10.1371/journal.pone.0132336.
Medvedev AE. Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer. J Interferon Cytokine Res. 2013;33:467–84. https://doi.org/10.1089/jir.2012.0140.
Medzhitov R, Janeway Jr CA. Decoding the patterns of self and nonself by the innate immune system. Science. 2002;296:298–300. https://doi.org/10.1126/science.1068883.
Oliveira-Nascimento L, Massari P, Wetzler LM. The role of TLR2 in infection and immunity. Front Immunol. 2012;3:79. https://doi.org/10.3389/fimmu.2012.00079.
Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A. 2000;97:13766–71. https://doi.org/10.1073/pnas.250476497.
Ramasawmy R, Cunha-Neto E, Fae KC, Borba SC, Teixeira PC, Ferreira SC, et al. Heterozygosity for the S180 L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy. J Infect Dis. 2009;199:1838–45. https://doi.org/10.1086/599212.
Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA. 2005;102:9577–82. https://doi.org/10.1073/pnas.0502272102.
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA. 1998;95:588–93.
Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004;16:3–9.
Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17:1–14. https://doi.org/10.1093/intimm/dxh186.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443–51.
Tsuji S, Matsumoto M, Takeuchi O, Akira S, Azuma I, Hayashi A, et al. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect Immun. 2000;68:6883–90.
van Bergenhenegouwen J, Plantinga TS, Joosten LA, Netea MG, Folkerts G, Kraneveld AD, et al. TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors. J Leukocyte Biol. 2013;94:885–902. https://doi.org/10.1189/jlb.0113003.
Yamashita T, Freigang S, Eberle C, Pattison J, Gupta S, Napoli C, et al. Maternal immunization programs postnatal immune responses and reduces atherosclerosis in offspring. Circ Res. 2006;99:e51–64. https://doi.org/10.1161/01.RES.0000244003.08127.cc.
Acknowledgments
This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).
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Durai, P., Choi, S. (2018). Toll-Like Receptor 2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101495
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101495
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