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SB623 Preclinical and Clinical Trial Experience

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Cellular and Molecular Approaches to Regeneration and Repair

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Stroke affects more than 15 million individuals each year, and is the second leading cause of mortality worldwide [1]. In the United States alone, there are nearly 800,000 strokes annually, and over seven million individuals (approximately 3% of the adult population) live with the sequelae of a prior stroke [2]. More than half of these individuals suffer from long-term limitation of functional mobility [3]. From an economic perspective, the direct and indirect costs related to stroke are as high as $65 billion per year in the United States [4].

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Abbreviations

AE:

Adverse event

BDNF:

Brain-derived neurotrophic factor

bFGF:

Basic fibroblast growth factor

DWI:

Diffusion-weighted imaging

ECM:

Extracellular matrix

EGF:

Epidermal growth factor

ESC:

Embryonic stem cells

ESS:

European Stroke Scale

FDA:

Food and Drug Administration

FMA:

Fugl-Meyer Assessment

GDNF:

Glial cell line-derived neurotrophic factor

IGF-1:

Insulin-like growth factor 1

MRI:

Magnetic resonance imaging

mRS:

Modified Rankin Scale

MSC:

Mesenchymal stem cells

NIHSS:

National Institute of Health Stroke Scale

NSC:

Neural stem cells

RCT:

Randomized controlled trial MCA, middle cerebral artery

T2 FLAIR:

T2-weighted-fluid-attenuated inversion recovery

TEAE:

Treatment emergent adverse event

VEGF:

Vascular endothelial growth factor

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Acknowledgments

We thank Christine Plant for assistance with the manuscript.

Funding: This work was supported in part by funding from Bernard and Ronni Lacroute, the William Randolph Hearst Foundation and Marc Paskin.

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Authors and Affiliations

  1. Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine and Stanford Health Care, Stanford University, 300 Pasteur Drive, MC 5327, Stanford, CA, 94305, USA

    Eric S. Sussman M.D. & Gary K. Steinberg M.D., Ph.D.

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  1. Eric S. Sussman M.D.
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  2. Gary K. Steinberg M.D., Ph.D.
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Corresponding author

Correspondence to Eric S. Sussman M.D. .

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Editors and Affiliations

  1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, AHSP, Los Angeles, California, USA

    Paul A. Lapchak

  2. Department of Physiology, Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Sussman, E.S., Steinberg, G.K. (2018). SB623 Preclinical and Clinical Trial Experience. In: Lapchak, P., Zhang, J. (eds) Cellular and Molecular Approaches to Regeneration and Repair. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-66679-2_14

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  • DOI: https://doi.org/10.1007/978-3-319-66679-2_14

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