Skip to main content

Persistent Lower Respiratory Symptoms in the World Trade Center (WTC) Survivor Program, a Treatment Program for Community Members

  • Chapter
  • First Online:
World Trade Center Pulmonary Diseases and Multi-Organ System Manifestations

Abstract

Hundreds of thousands of community members (local residents, local workers, cleanup workers, students, and passersby) were exposed to the massive dust cloud released by the collapse of the World Trade Center towers on September 11, 2001. Many also had chronic exposures to settled and resuspended dust in indoor and outdoor spaces and to fumes from fires that burned for months. Although funding for treatment and monitoring of this population lagged behind that of rescue and recovery workers, local communities and physicians were concerned early on about the potential adverse health effects of this group’s complex and varied WTC exposures, and the Bellevue Hospital Asthma Clinic began treating community members with respiratory symptoms soon after the disaster. Over the years, the program has evolved and grown and, with the passing of the Zadroga Act in 2010, earned ongoing federal funding as part of the World Trade Center Health Program (WTCHP), which provides comprehensive treatment and monitoring to both “responders” and “survivors” (community members). The World Trade Center Environmental Health Center (WTC EHC) at Bellevue Hospital, the flagship Center of Excellence for the Survivor Program, provides multidisciplinary medical and mental health treatment to symptomatic WTC-exposed community members. Mirroring findings in rescue and recovery populations, studies from the WTC EHC, World Trade Center Health Registry, and others have documented persistent lower respiratory symptoms, mental health symptoms, and abnormalities of distal airway function in community members exposed to WTC dust, gas, and fumes. Ongoing monitoring, treatment, and research are essential to detect emerging health effects, improve treatment, and prevent adverse outcomes to communities affected by environmental disasters.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brackbill RM, Thorpe LE, DiGrande L, Perrin M, Sapp JH II, Wu D, et al. Surveillance for world trade center disaster health effects among survivors of collapsed and damaged buildings. MMWR Surveill Summ. 2006;55(2):1–18.

    PubMed  Google Scholar 

  2. Reibman J, Levy-Carrick N, Miles T, Flynn K, Hughes C, Crane M, et al. Destruction of the world trade center towers. Lessons learned from an environmental health disaster. Ann Am Thorac Soc. 2016;13(5):577–83.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Whitman CT. EPA press release. 2001.

    Google Scholar 

  4. Lioy PJ, Pellizzari E, Prezant D. The world trade center aftermath and its effects on health: understanding and learning through human-exposure science. Environ Sci Technol. 2006;40(22):6876–85.

    Article  CAS  PubMed  Google Scholar 

  5. Yiin LM, Millette JR, Vette A, et al. Comparisons of the dust/smoke particulate that settled inside the surrounding buildings and outside on the streets of southern new York City after the collapse of the world trade center, Sept 11, 2001. J Air Waste Manage Assoc. 2004;54(5):515–28.

    Article  CAS  Google Scholar 

  6. New York City Department of Health, press release. Recommendations for people re-occupying commercial buildings and residents re-entering their homes. 17 Sept 2001.

    Google Scholar 

  7. Nadler J. U.S. congressman Jerrold Nadler white paper lower manhattan air quality. 2002.

    Google Scholar 

  8. Lippmann M, Cohen MD, Chen LC. Health effects of world trade center (WTC) dust: an unprecedented disaster’s inadequate risk management. Crit Rev Toxicol. 2015;45(6):492–530.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lioy PJ, Weisel CP, Millette JR, Eisenreich S, Vallero D, Offenberg J, et al. Characterization of the dust/smoke aerosol that settled east of the world trade center (WTC) in lower Manhattan after the collapse of the WTC 11 September 2001. Environ Health Perspect. 2002;110(7):703–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Butt CM, Diamond ML, Truong J, Ikonomou MG, Helm PA, Stern GA. Semivolatile organic compounds in window films from lower Manhattan after the September 11th world trade center attacks. Environ Sci Technol. 2004;38(13):3514–24.

    Article  CAS  PubMed  Google Scholar 

  11. Olson DA, Norris GA, Landis MS, Vette AF. Chemical characterization of ambient particulate matter near the world trade center: elemental carbon, organic carbon, and mass reconstruction. Environ Sci Technol. 2004;38(17):4465–73.

    Article  CAS  PubMed  Google Scholar 

  12. Crane MA, Levy-Carrick NC, Crowley L, Barnhart D, Dudas M, Onuoha U, et al. The response to September 11: a disaster case study. Ann Glob Health. 2014;80(4):320–31.

    Article  PubMed  Google Scholar 

  13. Herbert R, Moline J, Skloot G, Metzger K, Baron S, Luft B, et al. The world trade center disaster and the health of workers: five-year assessment of a unique medical screening program. Environ Health Perspect. 2006;114(12):1853–8.

    PubMed  PubMed Central  Google Scholar 

  14. Webber MP, Gustave J, Lee R, Niles JK, Kelly K, Cohen HW, et al. Trends in respiratory symptoms of firefighters exposed to the world trade center disaster: 2001–2005. Environ Health Perspect. 2009;117(6):975–80.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Feldman DM, Baron SL, Bernard BP, Lushniak BD, Banauch G, Arcentales N, et al. Symptoms, respirator use, and pulmonary function changes among new York City firefighters responding to the world trade center disaster. Chest. 2004;125(4):1256–64.

    Article  PubMed  Google Scholar 

  16. Prezant DJ, Weiden M, Banauch GI, McGuinness G, Rom WN, Aldrich TK, et al. Cough and bronchial responsiveness in firefighters at the world trade center site. N Engl J Med. 2002;347(11):806–15.

    Article  PubMed  Google Scholar 

  17. Banauch GI, Dhala A, Prezant DJ. Pulmonary disease in rescue workers at the world trade center site. Curr Opin Pulm Med. 2005;11(2):160–8.

    Article  CAS  PubMed  Google Scholar 

  18. Farfel M, DiGrande L, Brackbill R, Prann A, Cone J, Friedman S, et al. An overview of 9/11 experiences and respiratory and mental health conditions among world trade center health registry enrollees. J Urban Health. 2008;85(6):880–909.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Centers for Disease Control and Prevention. WTC health program at a glance. 2017. http://www.cdc.gov/wtc/ataglance.html

  20. Guidotti TL, Prezant D, de la Hoz RE, Miller A. The evolving spectrum of pulmonary disease in responders to the world trade center tragedy. Am J Ind Med. 2011;54(9):649–60.

    Article  PubMed  Google Scholar 

  21. Maslow CB, Friedman SM, Pillai PS, Reibman J, Berger KI, Goldring R, et al. Chronic and acute exposures to the world trade center disaster and lower respiratory symptoms: area residents and workers. Am J Public Health. 2012;102(6):1186–94.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Bromet EJ, Hobbs MJ, Clouston SA, Gonzalez A, Kotov R, Luft BJ. DSM-IV post-traumatic stress disorder among world trade center responders 11-13 years after the disaster of 11 September 2001 (9/11). Psychol Med. 2016;46(4):771–83.

    Article  CAS  PubMed  Google Scholar 

  23. Kotov R, Bromet EJ, Schechter C, et al. Posttraumatic stress disorder and the risk of respiratory problems in world trade center responders: longitudinal test of a pathway. Psychosom Med. 2015;77(4):438–48.

    Article  PubMed  Google Scholar 

  24. Maslow CB, Caramanica K, Welch AE, Stellman SD, Brackbill RM, Farfel MR. Trajectories of scores on a screening instrument for PTSD among world trade center rescue, recovery, and clean-up workers. J Trauma Stress. 2015;28(3):198–205.

    Article  PubMed  Google Scholar 

  25. Lin S, Reibman J, Bowers JA, et al. Upper respiratory symptoms and other health effects among residents living near the world trade center site after September 11, 2001. Am J Epidemiol. 2005;162(6):499–507.

    Article  PubMed  Google Scholar 

  26. Reibman J, Lin S, Hwang SA, Gulati M, Bowers JA, Rogers L, et al. The world trade center residents' respiratory health study: new-onset respiratory symptoms and pulmonary function. Environ Health Perspect. 2005;113(4):406–11.

    Article  CAS  PubMed  Google Scholar 

  27. Lin S, Jones R, Reibman J, Bowers J, Fitzgerald EF, Hwang SA. Reported respiratory symptoms and adverse home conditions after 9/11 among residents living near the world trade center. J Asthma. 2007;44(4):325–32.

    Article  PubMed  Google Scholar 

  28. Li J, Brackbill RM, Stellman SD, Farfel MR, Miller-Archie SA, Friedman S, et al. Gastroesophageal reflux symptoms and comorbid asthma and posttraumatic stress disorder following the 9/11 terrorist attacks on world trade center in new York City. Am J Gastroenterol. 2011;106(11):1933–41.

    Article  PubMed  Google Scholar 

  29. Nair HP, Ekenga CC, Cone JE, Brackbill RM, Farfel MR, Stellman SD. Co-occurring lower respiratory symptoms and posttraumatic stress disorder 5 to 6 years after the world trade center terrorist attack. Am J Public Health. 2012;102(10):1964–73.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Stellman SD, Thomas PA, SO S, Brackbill RM, Farfel MR. Respiratory health of 985 children exposed to the world trade center disaster: report on world trade center health registry wave 2 follow-up, 2007-2008. J Asthma. 2013;50(4):354–63.

    Article  PubMed  Google Scholar 

  31. Szema AM, Savary KW, Ying BL, Lai K. Post 9/11: high asthma rates among children in Chinatown, New York. Allergy Asthma Proc. 2009;30(6):605–11.

    Article  PubMed  Google Scholar 

  32. Thomas PA, Brackbill R, Thalji L, DiGrande L, Campolucci S, Thorpe L, et al. Respiratory and other health effects reported in children exposed to the world trade center disaster of 11 September 2001. Environ Health Perspect. 2008;116(10):1383–90.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Reibman J, Liu M, Cheng Q, Liautaud S, Rogers L, Lau S, et al. Characteristics of a residential and working community with diverse exposure to world trade center dust, gas, and fumes. J Occup Environ Med. 2009;51(5):534–41.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Caplan-Shaw C, Kazeros A, Pradhan D, Berger K, Goldring R, Zhao S, et al. Improvement in severe lower respiratory symptoms and small airway function in world trade center dust exposed community members. Am J Ind Med. 2016;59(9):777–87.

    Article  PubMed  Google Scholar 

  35. Friedman SM, Farfel MR, Maslow CB, Cone JE, Brackbill RM, Stellman SD. Comorbid persistent lower respiratory symptoms and posttraumatic stress disorder 5–6 years post-9/11 in responders enrolled in the world trade center health registry. Am J Ind Med. 2013;56(11):1251–61.

    PubMed  Google Scholar 

  36. Gross R, Neria Y, Tao XG, Massa J, Ashwell L, Davis K, et al. Posttraumatic stress disorder and other psychological sequelae among world trade center clean up and recovery workers. Ann N Y Acad Sci. 2006;1071:495–9.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Luft BJ, Schechter C, Kotov R, Broihier J, Reissman D, Guerrera K, et al. Exposure, probable PTSD and lower respiratory illness among world trade center rescue, recovery and clean-up workers. Psychol Med. 2012;42(5):1069–79.

    Article  CAS  PubMed  Google Scholar 

  38. Niles JK, Webber MP, Gustave J, Cohen HW, Zeig-Owens R, Kelly KJ, et al. Comorbid trends in world trade center cough syndrome and probable posttraumatic stress disorder in firefighters. Chest. 2011;140(5):1146–54.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Jordan HT, Stellman SD, Reibman J, Farfel MR, Brackbill RM, Friedman SM, et al. Factors associated with poor control of 9/11-related asthma 10-11 years after the 2001 world trade center terrorist attacks. J Asthma. 2015;52(6):630–7.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Friedman SM, Farfel MR, Maslow C, Jordan HT, Li J, Alper H, et al. Risk factors for and consequences of persistent lower respiratory symptoms among world trade center health registrants 10 years after the disaster. Occup Environ Med. 2016;73(10):676–84.

    Article  PubMed  Google Scholar 

  41. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159(1):179–87.

    Article  CAS  PubMed  Google Scholar 

  42. Crowley LE, Herbert R, Moline JM, Wallenstein S, Shukla G, Schechter C, et al. “Sarcoid like” granulomatous pulmonary disease in world trade center disaster responders. Am J Ind Med. 2011;54(3):175–84.

    Article  PubMed  Google Scholar 

  43. Izbicki G, Chavko R, Banauch GI, Weiden MD, Berger KI, Aldrich TK, et al. World trade center “sarcoid-like” granulomatous pulmonary disease in new York City fire Department rescue workers. Chest. 2007;131(5):1414–23.

    Article  PubMed  Google Scholar 

  44. Liu M, Qian M, Cheng Q, Berger KI, Shao Y, Turetz M, et al. Longitudinal spirometry among patients in a treatment program for community members with world trade center-related illness. J Occup Environ Med. 2012;54(10):1208–13.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Berger KI, Reibman J, Oppenheimer BW, Vlahos I, Harrison D, Goldring RM. Lessons from the world trade center disaster: airway disease presenting as restrictive dysfunction. Chest. 2013;144(1):249–57.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kazeros A, Maa MT, Patrawalla P, Liu M, Shao Y, Qian M, et al. Elevated peripheral eosinophils are associated with new-onset and persistent wheeze and airflow obstruction in world trade center-exposed individuals. J Asthma. 2013;50(1):25–32.

    Article  PubMed  Google Scholar 

  47. Contoli M, Bousquet J, Fabbri LM, Magnussen H, Rabe KF, Siafakas NM, et al. The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy. 2010;65(2):141–51.

    Article  CAS  PubMed  Google Scholar 

  48. Mead J. The lung’s “quiet zone”. N Engl J Med. 1970;282(23):1318–9.

    Article  CAS  PubMed  Google Scholar 

  49. Hewitt DJ. Interpretation of the “positive” methacholine challenge. Am J Ind Med. 2008;51(10):769–81.

    Article  PubMed  Google Scholar 

  50. Friedman SM, Maslow CB, Reibman J, Pillai PS, Goldring RM, Farfel MR, et al. Am J Respir Crit Care Med. 2011;184(5):582–9.

    Google Scholar 

  51. Oppenheimer BW, Goldring RM, Herberg ME, Hofer IS, Reyfman PA, Liautaud S, et al. Distal airway function in symptomatic subjects with normal spirometry following world trade center dust exposure. Chest. 2007;132(4):1275–82.

    Article  PubMed  Google Scholar 

  52. Berger KI, Turetz M, Liu M, Shao Y, Kazeros A, Parsia S, et al. Oscillometry complements spirometry in evaluation of subjects following toxic inhalation. ERJ Open Res. 2015;1(2):00043–2015.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Berger KI, Kalish S, Shao Y, Marmor M, Kazeros A, Oppenheimer BW, et al. Am J Ind Med. 2016;59(9):767–76.

    Article  PubMed  Google Scholar 

  54. Kazeros A, Zhang E, Cheng X, Shao Y, Liu M, Qian M, et al. Systemic inflammation associated with world trade center dust exposure and airways abnormalities in the local community. J Occup Environ Med. 2015;57(6):610–6.

    Article  PubMed  Google Scholar 

  55. Mendelson DS, Roggeveen M, Levin SM, Herbert R, de la Hoz RE. Air trapping detected on end-expiratory high-resolution computed tomography in symptomatic world trade center rescue and recovery workers. J Occup Environ Med. 2007;49(8):840–5.

    Article  PubMed  Google Scholar 

  56. Weiden MD, Ferrier N, Nolan A, Rom WN, Comfort A, Gustave J, et al. Obstructive airways disease with air trapping among firefighters exposed to world trade center dust. Chest. 2010;137(3):566–74.

    Article  PubMed  Google Scholar 

  57. Rom WN, Weiden M, Garcia R, Yie TA, Vathesatogkit P, Tse DB, et al. Acute eosinophilic pneumonia in a new York City firefighter exposed to world trade center dust. Am J Respir Crit Care Med. 2002;166(6):797–800.

    Article  PubMed  Google Scholar 

  58. Fireman EM, Lerman Y, Ganor E, Greif J, Fireman-Shoresh S, Lioy PJ, et al. Induced sputum assessment in new York City firefighters exposed to world trade center dust. Environ Health Perspect. 2004;112(15):1564–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Mann JM, Sha KK, Kline G, Breuer FU, Miller A. World trade center dyspnea: bronchiolitis obliterans with functional improvement: a case report. Am J Ind Med. 2005;48(3):225–9.

    Article  PubMed  Google Scholar 

  60. Wu M, Gordon RE, Herbert R, Padilla M, Moline J, Mendelson D, et al. Case report: lung disease in world trade center responders exposed to dust and smoke: carbon nanotubes found in the lungs of world trade center patients and dust samples. Environ Health Perspect. 2010;118(4):499–504.

    Article  CAS  PubMed  Google Scholar 

  61. Caplan-Shaw CE, Yee H, Rogers L, Abraham JL, Parsia SS, Naidich DP, et al. Lung pathologic findings in a local residential and working community exposed to world trade center dust, gas, and fumes. J Occup Environ Med. 2011;53(9):981–91.

    Article  CAS  PubMed  Google Scholar 

  62. Parsia SS, Yee H, Young S, et al. Characteristics of sarcoidosis in residents and workers exposed to world trade center dust, gas and fumes presenting for medical care. Am J Respir Crit Care Med. 2010;181:A1740.

    Google Scholar 

Download references

Funding

 Centers for Disease Control and Prevention (CDC)-National Institute for Occupational Services and Health (NIOSH) #200-2011-39413 Evaluation of Distal Airway Injury Following Exposure to World Trade Center Dust U01 OH011317 Small Airway COPD in the Survivor Population U01OH010404 Uncontrolled Lower Respiratory Symptoms in WTC Survivor Population Clinical Center of Excellence: 1E11OH0030 (2008 – 2011) 200-2011-39391C (previous), 200-2017-93427 (current) Data Center: 200-2011-39379C (previous), 200-2017-93327 (current)

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Caralee Caplan-Shaw M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Caplan-Shaw, C., Reibman, J. (2018). Persistent Lower Respiratory Symptoms in the World Trade Center (WTC) Survivor Program, a Treatment Program for Community Members. In: Szema, A. (eds) World Trade Center Pulmonary Diseases and Multi-Organ System Manifestations. Springer, Cham. https://doi.org/10.1007/978-3-319-59372-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59372-2_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59371-5

  • Online ISBN: 978-3-319-59372-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics