Skip to main content

Pathology of Melanoma

  • Chapter
  • First Online:
PET/CT in Melanoma

Abstract

Melanoma is a malignant proliferation of neoplastic melanocytes. These occur as primary lesions in any region where melanocytes are resident, including the skin, mucosa, uveal tract and meninges. Additionally metastatic melanoma may present without an identified primary lesion. This chapter will concentrate primarily on cutaneous melanoma, which represents around 90% of cases of melanoma in regions with predominant Caucasian populations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Edge SB, American Joint Committee on Cancer, American Cancer Society. AJCC cancer staging manual. 7th ed. New York; London: Springer; 2010. xiv, 648p.

    Google Scholar 

  2. van Akkooi AC, et al. Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes. Ann Surg. 2008;248(6):949–55.

    Article  PubMed  Google Scholar 

  3. Hayward NK. Genetics of melanoma predisposition. Oncogene. 2003;22(20):3053–62.

    Article  CAS  PubMed  Google Scholar 

  4. Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol. 2005;6(11):827–37.

    Article  CAS  PubMed  Google Scholar 

  5. Davies H, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949–54.

    Article  CAS  PubMed  Google Scholar 

  6. Pollock PM, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33(1):19–20.

    Article  CAS  PubMed  Google Scholar 

  7. Goydos JS, et al. Detection of B-RAF and N-RAS mutations in human melanoma. J Am Coll Surg. 2005;200(3):362–70.

    Article  PubMed  Google Scholar 

  8. Horn S, et al. TERT promoter mutations in familial and sporadic melanoma. Science. 2013;339(6122):959–61.

    Article  CAS  PubMed  Google Scholar 

  9. Huang FW, et al. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339(6122):957–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Curtin JA, et al. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006;24(26):4340–6.

    Article  CAS  PubMed  Google Scholar 

  11. Chapman PB, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ribas A, et al. Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study. Lancet Oncol. 2014;15(9):954–65.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew J. Colebatch .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Colebatch, A.J., McArthur, G.A. (2017). Pathology of Melanoma. In: Hofman, M., Hicks, R. (eds) PET/CT in Melanoma. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-54741-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-54741-1_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54740-4

  • Online ISBN: 978-3-319-54741-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics