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Drug Addiction and DNA Modifications

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Neuroepigenomics in Aging and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 978))

Abstract

Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes may underlie the causes and possibly treatment of substance use disorders. This chapter will focus on epigenetic modifications to DNA, which include DNA methylation and several recently defined additional DNA epigenetic changes. We will discuss the functions of DNA modifications and methods for detecting them, followed by a description of the research investigating the function and consequences of drug-induced changes in DNA methylation patterns. Understanding these epigenetic changes may provide us translational tools for the diagnosis and treatment of addiction in the future.

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Authors and Affiliations

  1. Department of Biological Science, Florida State University, 319 Stadium Drive, Tallahassee, FL, 32306, USA

    Amber N. Brown & Jian Feng

  2. Neuroscience Program, Florida State University, 319 Stadium Drive, Tallahassee, FL, 32306, USA

    Jian Feng

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  1. Amber N. Brown
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  2. Jian Feng
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Correspondence to Jian Feng .

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  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

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Brown, A.N., Feng, J. (2017). Drug Addiction and DNA Modifications. In: Delgado-Morales, R. (eds) Neuroepigenomics in Aging and Disease. Advances in Experimental Medicine and Biology(), vol 978. Springer, Cham. https://doi.org/10.1007/978-3-319-53889-1_6

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