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Spatiotemporal Models of the Asymmetric Division Cycle of Caulobacter crescentus

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Asymmetric Cell Division in Development, Differentiation and Cancer

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 61))

Abstract

The spatial localization of proteins within the cytoplasm of bacteria is an underappreciated but critical aspect of cell cycle regulation for many prokaryotes. In Caulobacter crescentus—a model organism for the study of asymmetric cell reproduction in prokaryotes—heterogeneous localization of proteins has been identified as the underlying cause of asymmetry in cell morphology, DNA replication, and cell division. However, significant questions remain. Firstly, the mechanisms by which proteins localize in the organelle-free prokaryotic cytoplasm remain obscure. Furthermore, how variations in the spatial and temporal dynamics of cell fate determinants regulate signaling pathways and orchestrate the complex programs of asymmetric cell division and differentiation are subjects of ongoing research. In this chapter, we review current efforts in investigating these two questions. We describe how mathematical models of spatiotemporal protein dynamics are being used to generate and test competing hypotheses and provide complementary insight about the control mechanisms that regulate asymmetry in protein localization and cell division.

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Acknowledgements

The work on mathematical models presented in this chapter (Subramanian et al. 2013, 2014, 2015) was funded by the National Science Foundation (Division of Mathematical Sciences-1225160). Ongoing investigation of the Caulobacter crescentus cell cycle is currently being funded by the National Science Foundation grant (MCB-1613741). Subramanian is currently a postdoctoral fellow in the Sorger Lab at Harvard Medical School (Funding no: GM107618).

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Authors and Affiliations

  1. Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA

    Kartik Subramanian

  2. Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061, USA

    John J. Tyson

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Correspondence to Kartik Subramanian .

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  1. IGDR, UMR 6290, CNRS, Université de Rennes 1, Rennes, France

    Jean-Pierre Tassan

  2. Inst of Genetics & Dev of Rennes IG, CNRS/Unive Rennes 1 UMR 6290, Rennes Cedex, France

    Jacek Z. Kubiak

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Subramanian, K., Tyson, J.J. (2017). Spatiotemporal Models of the Asymmetric Division Cycle of Caulobacter crescentus . In: Tassan, JP., Kubiak, J. (eds) Asymmetric Cell Division in Development, Differentiation and Cancer. Results and Problems in Cell Differentiation, vol 61. Springer, Cham. https://doi.org/10.1007/978-3-319-53150-2_2

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