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Obesity, Persistent Organic Pollutants and Related Health Problems

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Obesity and Lipotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 960))

Abstract

The present review aims to delve into persistent organic pollutants (POPs) , as xenobiotics, in correlation to human health. POPs exhibit a group of common characteristics, including lipophilicity, persistence to decomposition and bioaccumulation in tissues. POPs have been thoroughly studied by former researchers, as they offer a particular interest in the elucidation of metabolic, endocrine and immune perturbation caused by their synergy with intracellular mechanisms. Herein particular focus is attributed to the relationship of POPs with obesity provocation. Obesity nowadays receives epidemic dimensions, as its prevalence elevates in an exponential degree. POPs-induced obesity rotates around interfering in metabolic and endocrinal procedures and interacting with peroxisome-proliferator and retinoic receptors. Moreover, polymorphisms in CYP gene families exert a negative result, as they incapacitate detoxification of POPs. Obesity could be deemed as a multidimensional condition, as various factors interact to lead to an obesogenic result. Therefore, concomitant disorders may occur, from mild to lethal, and get intensified due to POPs exposure. POPs exact function mechanisms remain rather enigmatic, thus further investigation should be prospectively performed, for a more lucid picture of this issue, and, consequently for the establishment of alternative solutions.

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Authors and Affiliations

  1. Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409, Heraklion, Crete, Greece

    Loukia Vassilopoulou, Christos Psycharakis & Demetrios Petrakis

  2. Laboratory of Anatomy, Medical School, University of Crete, Voutes, 71110, Heraklion, Crete, Greece

    John Tsiaoussis

  3. Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece

    Aristides M. Tsatsakis

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  1. Loukia Vassilopoulou
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    Ayse Basak Engin

  2. Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey

    Atilla Engin

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Vassilopoulou, L., Psycharakis, C., Petrakis, D., Tsiaoussis, J., Tsatsakis, A.M. (2017). Obesity, Persistent Organic Pollutants and Related Health Problems. In: Engin, A., Engin, A. (eds) Obesity and Lipotoxicity. Advances in Experimental Medicine and Biology, vol 960. Springer, Cham. https://doi.org/10.1007/978-3-319-48382-5_4

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