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Experiences with Aber-OWL, an Ontology Repository with OWL EL Reasoning

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Ontology Engineering (OWLED 2015)

Abstract

Ontologies are widely used in biology and biomedicine for the annotation and integration of data, and hundreds of ontologies have been developed for this purpose. These ontologies also constitute large volumes of formalized domain knowledge, usually expressed in the Web Ontology Language (OWL). Computational access to the knowledge contained within them relies on the use of automated reasoning. We have developed Aber-OWL, an ontology repository that provides OWL EL reasoning to answer queries and verify the consistency of ontologies. Aber-OWL also provides a set of web services which provide ontology-based access to scientific literature in Pubmed and Pubmed Central, SPARQL query expansion to retrieve linked data, and integration with Bio2RDF. Here, we report on our experiences with Aber-OWL and outline a roadmap for future development. Aber-OWL is freely available at http://aber-owl.net.

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References

  1. Ashburner, M., Ball, C.A., Blake, J.A., Botstein, D., Butler, H., Cherry, M.J., Davis, A.P., Dolinski, K., Dwight, S.S., Eppig, J.T., Harris, M.A., Hill, D.P., Tarver, L.I., Kasarskis, A., Lewis, S., Matese, J.C., Richardson, J.E., Ringwald, M., Rubin, G.M., Sherlock, G.: Gene ontology: tool for the unification of biology. Nat. Genet. 25(1), 25–29 (2000). http://dx.doi.org/10.1038/75556

    Article  Google Scholar 

  2. Bail, S., Glimm, B., Jiménez-Ruiz, E., Matentzoglu, N., Parsia, B., Steigmiller, A. (eds.): ORE 2014: OWL Reasoner Evaluation Workshop. No. 1207 in CEUR Workshop Proceedings. CEUR-WS.org, Aachen, Germany (2014)

    Google Scholar 

  3. Belleau, F., Nolin, M., Tourigny, N., Rigault, P., Morissette, J.: Bio2RDF: towards a mashup to build bioinformatics knowledge systems. J. Biomed. Inform. 41(5), 706–716 (2008). http://dx.doi.org/10.1016/j.jbi.2008.03.004

    Article  Google Scholar 

  4. Bienvenu, M., ten Cate, B., Lutz, C., Wolter, F.: Ontology-based data access: a study through disjunctive datalog, CSP, and MMSNP. In: PODS, pp. 213–224 (2013)

    Google Scholar 

  5. Cote, R., Jones, P., Apweiler, R., Hermjakob, H.: The ontology lookup service, a lightweight cross-platform tool for controlled vocabulary queries. BMC Bioinform. 7(1), 97 (2006). http://dx.doi.org/10.1186/1471-2105-7-97

    Article  Google Scholar 

  6. Grau, B., Horrocks, I., Motik, B., Parsia, B., Patelschneider, P., Sattler, U.: OWL 2: the next step for OWL. Web Seman. Sci. Serv. Agents World Wide Web 6(4), 309–322 (2008). http://dx.doi.org/10.1016/j.websem.2008.05.001

    Article  Google Scholar 

  7. Hoehndorf, R., Oellrich, A., Dumontier, M., Kelso, J., Rebholz-Schuhmann, D., Herre, H.: Relations as patterns: bridging the gap between OBO and OWL. BMC Bioinform. 11(1), 441 (2010)

    Article  Google Scholar 

  8. Hoehndorf, R., Schofield, P.N., Gkoutos, G.V.: Analysis of the human diseasome using phenotype similarity between common, genetic, and infectious diseases. Sci. Rep. 5, Article no. 10888 (2015). http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-441

  9. Hoehndorf, R., Schofield, P.N., Gkoutos, G.V.: The role of ontologies in biological and biomedical research: a functional perspective. Briefings Bioinform. 16(6), 1069–1080 (2015). https://bib.oxfordjournals.org/content/16/6/1069.full

    Article  Google Scholar 

  10. Hoehndorf, R., Slater, L., Schofield, P.N., Gkoutos, G.V.: Aber-OWL: a framework for ontology-based data access in biology. BMC Bioinform. 16, 26 (2015). http://www.biomedcentral.com/1471-2105/16/26/abstract

    Article  Google Scholar 

  11. Horridge, M., Drummond, N., Goodwin, J., Rector, A., Stevens, R., Wang, H.: The Manchester OWL syntax. In: Proceedings of the 2006 OWL Experiences and Directions Workshop (OWL-ED 2006) (2006)

    Google Scholar 

  12. Horrocks, I.: OBO flat file format syntax and semantics and mapping to OWL Web Ontology Language. Technical report, University of Manchester, March 2007. http://www.cs.man.ac.uk/~horrocks/obo/

  13. Kazakov, Y., Krötzsch, M., Simancik, F.: The incredible ELK. J. Autom. Reasoning 53(1), 1–61 (2014). http://dx.doi.org/10.1007/s10817-013-9296-3

    Article  MATH  Google Scholar 

  14. Noy, N.F., Shah, N.H., Whetzel, P.L., Dai, B., Dorf, M., Griffith, N., Jonquet, C., Rubin, D.L., Storey, M.A.A., Chute, C.G., Musen, M.A.: Bioportal: ontologies and integrated data resources at the click of a mouse. Nucleic Acids Res. 37(Web Server issue), W170–W173 (2009). http://dx.doi.org/10.1093/nar/gkp440

    Article  Google Scholar 

  15. Slater, L., Gkoutos, G., Schofield, P.N., Hoehndorf, R.: Using Aber-OWL for fast and scalable reasoning over BioPortal ontologies. In: Proceedings of International Conference on Biomedical Ontologies (ICBO), pp. 72–76, July 2015. http://icbo2015.fc.ul.pt/ICBO2015Proceedings.pdf

  16. The Uniprot Consortium: The universal protein resource (uniprot). Nucleic Acids Res 35(Database issue), January 2007. http://view.ncbi.nlm.nih.gov/pubmed/17142230

  17. Usbeck, R., Ngonga Ngomo, A.C., Bühmann, L., Unger, C.: HAWK - hybrid question answering over linked data. In: 12th Extended Semantic Web Conference, 31st May – 4th 2015, Portoroz, Slovenia, June 2015

    Google Scholar 

  18. Xiang, Z., Mungall, C.J., Ruttenberg, A., He, Y.: Ontobee: a linked data server and browser for ontology terms. In: Proceedings of International Conference on Biomedical Ontology, pp. 279–281 (2011)

    Google Scholar 

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Correspondence to Miguel Ángel Rodríguez-García .

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Slater, L., Rodríguez-García, M.Á., O’Shea, K., Schofield, P.N., Gkoutos, G.V., Hoehndorf, R. (2016). Experiences with Aber-OWL, an Ontology Repository with OWL EL Reasoning. In: Tamma, V., Dragoni, M., Gonçalves, R., Ławrynowicz, A. (eds) Ontology Engineering. OWLED 2015. Lecture Notes in Computer Science(), vol 9557. Springer, Cham. https://doi.org/10.1007/978-3-319-33245-1_8

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  • DOI: https://doi.org/10.1007/978-3-319-33245-1_8

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