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Polymers for Surgery

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Advanced Polymers in Medicine

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Abstract

During surgery, tissue injuries occur intentionally and unintentionally. Intentional injuries include scission of skin to secure the operation area and resection of diseased tissues and organs, whereas accidental injuries can also occur presumably due to mechanical contact of devices and surgeon’s gloves with patient’s internal organs and tissues. Bioabsorbable polymers have been tremendously contributed to surgical applications for healing those injuries. They include surgical sealants, anti-adhesion barriers, fixation devices, and sutures. This chapter provides a detailed view on surgical bioabsorbable polymeric products that are commercially available as well as the activity of their current research and developments.

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Abbreviations

AAc:

Acrylic acid

CMC:

Carboxymethyl cellulose

DHA:

Dihydroxyacetone

DMA:

Dopamine methacrylamide

DOPA:

3,4-dihydroxy-l-phenylalanine

FDA:

Food and drug administration

GRF:

Gelatin-resorcinol-formaldehyde

HA:

Hyaluronic acid

MEA:

Methoxyethyl acrylate

MPEG:

Methoxypoly(ethylene glycol)

NHS:

N-hydroxysuccinimide

PCL:

Poly(ε-caprolactone)

PEG:

Poly(ethylene glycol)

PEO:

Poly(ethylene oxide)

PGA:

Polyglycolide

PGLA:

Poly(glycolide-co-l-lactide)

PGS:

Poly(glycerol sebacate)

PLLA:

Poly(l-lactide)

PVA:

Poly(vinyl alcohol)

PVP:

Polyvinylpyrrolidone

TAD:

Tartaric acid derivative

TMC:

Trimethylene carbonate

References

  1. Matsuda, S., Ikada, Y.: Glues. In: Bowlin, G.L., Wnek, G. (eds.) Encycropedia of Biomaterials and Biomedical Engineering. Marcel Dekker, NY (2004)

    Google Scholar 

  2. Gabay, M., Boucher, B.A.: An essential primer for understanding the role of topical hemostats, surgical sealants, and adhesives for maintaining hemostasis. Pharmacotherapy 33(9), 935–955 (2013)

    Google Scholar 

  3. Spotnitz, W.D., Burks, S.: State-of-the-art review: hemostats, sealants, and adhesives II: update as well as how and when to use the components of the surgical toolbox. Clin. Appl. Thromb. Hemost. 16(5), 497–514 (2010)

    CAS  Google Scholar 

  4. Spotnitz, W.D.: Hemostats, sealants, and adhesives: a practical guide for the surgeon. Am. Surg. 78(12), 1305–1321 (2012)

    Google Scholar 

  5. Lodi, D., Iannitti, T., Palmieri, B.: Management of haemostasis in surgery: sealant and glue applications. Blood Coagul. Fibrinolysis 23(6), 465–472 (2012)

    Google Scholar 

  6. Gosain, A.K., Lyon, V.B.: The corrent status of tissue glues: part II For adhesion of soft tissues. Plast. Reconstr. Surg. 110(6), 1581–1584 (2002)

    Google Scholar 

  7. Jackson, M.R.: Fibrin sealants in surgical practice: an overview. Am. J. Surg. 182, 1S–7S (2001)

    CAS  Google Scholar 

  8. Morikawa, T.: Tissue sealing. Am. J. Surg. 182, 29S–35S (2001)

    CAS  Google Scholar 

  9. Mandell, S.P., Gibran, N.S., Fibrin sealants: surgical hemostat, sealant and adhesive. Expert Opin. Biol. Ther. (2014)

    Google Scholar 

  10. Skovgaard, C., Holm, B., Troelsen, A., Lunn, T.H., Gaarn-Larsen, L., Kehlet, H., Husted, H.: No effect of fibrin sealant on drain output or functional recovery following simultaneous bilateral total knee arthroplasty: a randomized, double-blind, placebo-controlled study. Acta Orthop. 84(2), 153–158 (2013)

    Google Scholar 

  11. Miri Bonjar, M.R., Maghsoudi, H., Samnia, R., Saleh, P., Parsafar, F.: Efficacy of fibrin glue on seroma formation after breast surgery. Int. J. Breast Cancer (2012). doi:10.1155/2012/643132

    Google Scholar 

  12. Ennker, I.C., Ennker, J., Schoon, H.D., Rimpler, M., Hetzer, R.: Formaldehyde-free collagen glue in experimental lung gluing. Ann. Thorac. Surg. 57, 1622–1627 (1994)

    CAS  Google Scholar 

  13. Sawamura, Y., Asaoka, K., Terasaka, S., Tada, M., Uchida, T.: Evaluation of application techniques of fibrin sealant to prevent cerebrospinal fluid leakage: a new device for the application of aerosolized fibrin glue. Neurosurgery 44(2), 332–337 (1999)

    CAS  Google Scholar 

  14. Baker, J.W., Spotnitz, W.D., Nolan, S.P., A technique for spray application of fibrin glue during cardiac operations. Ann. Thorac. Surg. 43(5), 564–565 (1987)

    Google Scholar 

  15. Redl, H., Schlag, G., Dinges, H.P.: Methods of fibrin seal application. Thorac. Cardiovasc. Surg. 30(4), 223–227 (1982)

    CAS  Google Scholar 

  16. Minato, N., Shimokawa, T., Katayama, Y., Yamada, N., Sakaguchi, M., Itoh, M.: New application method of fibrin glue for more effective hemostasis in cardiovascular surgery: rub-and-spray method. Jpn. J. Thorac. Cardiovasc. Surg. 52(8), 361–366 (2004)

    Google Scholar 

  17. Minato, N., Katayama, Y., Yunoki, J., Kawasaki, H., Satou, H.: Hemostatic effectiveness of a new application method for fibrin glue, the “rub-and-spray method”, in emergency aortic surgery for acute aortic dissection. Ann. Thorac. Cardiovasc. Surg. 15(4), 265–271 (2009)

    Google Scholar 

  18. Miyamoto, H., Futagawa, T., Wang, Z., Yamazaki, A., Morio, A., Sonobe, S., Izumi, H., Hosoda, Y., Hata, E.: Fibrin glue and bioabsorbable felt patch for intraoperative intractable air leaks. Jpn. J. Thorac. Cardiovasc. Surg. 51(6), 232–236 (2003)

    Google Scholar 

  19. Yano, S., Tsuiki, H., Kudo, M., Kai, Y., Morioka, M., Takeshima, H., Yumoto, E., Kuratsu, J.: Sellar repair with resorbable polyglactin acid sheet and fibrin glue in endoscopic endonasal transsphenoidal surgery. Surg. Neurol. 67(1), 59–64 (2007)

    Google Scholar 

  20. Itano, H.: The optimal technique for combined application of fibrin sealant and bioabsorbable felt against alveolar air leakage. Eur. J. Cardiothorac. Surg. 33(3), 457–460 (2008)

    Google Scholar 

  21. Ueda, K., Ianaka, T., Li, T.S., Tanaka, N., Hamano, K.: Sutureless pneumostasis using bioabsorbable mesh and glue during major lung resection for cancer: who are the best candidates? J. Thorac. Cardiovasc. Surg. 139(3), 600–605 (2010)

    Google Scholar 

  22. Sugawara, T., Itoh, Y., Hirano, Y., Higashiyama, N., Shimada, Y., Kinouchi, H., Mizoi, K.: Novel dural closure technique using polyglactin acid sheet prevents cerebrospinal fluid leakage after spinal surgery. Neurosurgery 57(4 Suppl), 290–294 (2005)

    Google Scholar 

  23. Hida, K., Yamaguchi, S., Seki, T., Yano, S., Akino, M., Terasaka, S., Uchida, T., Iwasaki, Y.: Nonsuture dural repair using polyglycolic acid mesh and fibrin glue: clinical application to spinal surgery. Surg. Neurol. 65(2), 136–142 (2006)

    Google Scholar 

  24. Terasaka, S., Iwasaki, Y., Shinya, N., Uchida, T.: Fibrin glue and polyglycolic acid nonwoven fabric as a biocompatible dural substitute. Neurosurgery 58(1), ONS-134–139 (2006)

    Google Scholar 

  25. Shimada, Y., Hongo, M., Miyakoshi, N., Sugawara, T., Kasukawa, Y., Ando, S., Ishikawa, Y., Itoi, E.: Dural substitute with polyglycolic acid mesh and fibrin glue for dural repair: technical note and preliminary results. J. Orthop. Sci. 11(5), 454–458 (2006)

    CAS  Google Scholar 

  26. Hayashibe, A., Sakamoto, K., Shinbo, M., Makimoto, S., Nakamoto, T.: New method for prevention of bile leakage after hepatic resection. J. Surg. Oncol. 94(1), 57–60 (2006)

    Google Scholar 

  27. Hiura, Y., Takiguchi, S., Yamamoto, K., Kurokawa, Y., Yamasaki, M., Nakajima, K., Miyata, H., Fujiwara, Y., Mori, M., Doki, Y.: Use of fibrin glue sealant with polyglycolic acid sheets to prevent pancreatic fistula formation after laparoscopic-assisted gastrectomy. Surg. Today 43(5), 527–533 (2013)

    CAS  Google Scholar 

  28. Haas, S.: The use of a surgical patch coated with human coagulation factors in surgical routine: a multicenter postauthorization surveillance. Clin. Appl. Thromb. Hemost. 12(4), 445–450 (2006)

    Google Scholar 

  29. Simo, K.A., Hanna, E.M., Imagawa, D.K., Iannitti, D.A.: Hemostatic agents in hepatobiliary and pancreas surgery: a review of the literature and critical evaluation of a novel carrier-bound fibrin sealant (TachoSil). ISRN Surg. 2012, 729086 (2012)

    CAS  Google Scholar 

  30. Montorsi, M., Zerbi, A., Bassi, C., Capussotti, L., Coppola, R., Sacchi, M.: Italian Tachosil Study Group, Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trial. Ann. Surg. 256(5), 853–859 (2012)

    Google Scholar 

  31. Zacharias, T., Ferreira, N.: Carrier-bound fibrin sealant compared to oxidized cellulose application after liver resection. HPB (Oxford) 14(12), 839–847 (2012)

    Google Scholar 

  32. Di Monta, G., Caracò, C., Crispo, A., Marone, U., Mozzillo, N.: Collagen sealant patch to reduce lymphatic drainage after lymph node dissection. World J. Surg. Oncol. 10, 275 (2012)

    Google Scholar 

  33. Reddy, M., Schöggl, A., Reddy, B., Holzer, A., Saringer, W., Steiger, C., Matula, C.: Watertightness and effectiveness of a fibrinogen-based collagen fleece (TachoComb®) in neurosurgery. Eur. Surg. 35(5), 278–281 (2003)

    Google Scholar 

  34. Oz, M.C., Rondinone, J.F., Shargill, N.S.: Floseal matrix: new generation topical hemostatic sealant. J. Card. Surg. 18, 486–493 (2003)

    Google Scholar 

  35. Miyamoto, K., Masuda, K., Inoue, N., Okuma, M., Muehleman, C., An, H.S.: Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model: a biomechanical, biochemical, and histologic study. Spine (Phila Pa 1976) 31(4), E91–97 (2006)

    Google Scholar 

  36. Mayol, J.M., Zapata, C.: Gelatin-thrombin matrix for intraoperative hemostasis in abdomino-pelvic surgery: a systematic review. Surg. Technol. Int. 23, 23–28 (2013)

    Google Scholar 

  37. Yao, H.H., Hong, M.K., Drummond, K.J.: Haemostasis in neurosurgery: what is the evidence for gelatin-thrombin matrix sealant? J. Clin. Neurosci. 20(3), 349–356 (2013)

    CAS  Google Scholar 

  38. Samudrala, S.: Topical hemostatic agents in surgery: a surgeon’s perspective. AORN J. 88(3), S2–S11 (2008)

    Google Scholar 

  39. Guilmet, D., Bachet, J., Goudot, B., Laurian, C., Gigou, F., et al.: Use of biological glue in acute aortic dissection. Preliminary clinical results with a new surgical techinique. J. Thorac. Cardiovasc. Surg. 77, 516–521 (1979)

    CAS  Google Scholar 

  40. Freeman, L.E.B., Blair, A., Lubin, J.H., Stewart, P.A., Hayes, R.B., Hoover, R.N., Hauptmann, M.: Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort. J. Natl. Cancer Inst. 101(10), 751–761 (2009)

    Google Scholar 

  41. Bonchek, L.I., Braunwald, N.S.: Experimental evaluation of a cross-linked gelatin adhesive in gastrointestinal surgery. Ann. Surg. 165(3), 420–424 (1967)

    CAS  Google Scholar 

  42. Kazui, T., Washiyama, N., Bashar, A.H., Terada, H., Suzuki, K., et al.: Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root. Ann. Thorac. Surg. 72, 509–514 (2001)

    CAS  Google Scholar 

  43. Fukunaga, S., Karck, M., Harringer, W., Cremer, J., Rhein, C., et al.: The use of gelatin-resorcin-formalin glue in acute aortic dissection type A. Eur. J. Cardiothorac. Surg. 15, 564–570 (1999)

    CAS  Google Scholar 

  44. von Oppell, U.O., Karani, Z., Harringer, W., Cremer, J., Rhein, C., et al.: Dissected aortic sinuses repaired with gelatin-resorcin-formaldehyde (GRF) glue are not stable on follow up. J. Heart Valve Dis. 11, 249–257 (2002)

    Google Scholar 

  45. Chao, H.-H., Torchiana, D.F.: BioGlue: albumin/glutaraldehyde sealant in cardiac surgery. J. Card. Surg. 18, 500–503 (2003)

    Google Scholar 

  46. Azadani, A.N., Matthews, P.B., Ge, L., Shen, Y., Jhun, C.S., Guy, T.S., Tseng, E.E.: Mechanical properties of surgical glues used in aortic root replacement. Ann. Thorac. Surg. 87(4), 1154–1160 (2009)

    Google Scholar 

  47. Zehr, K.: Use of bovine albumin-glutaraldehyde glue in cardiovascular surgery. Ann. Thorac. Surg. 84, 1048–1052 (2007)

    Google Scholar 

  48. Coselli, J.S., Bavaria, J.E., Fehrenbacher, J., Stowe, C.L., Macheers, S.K., Gundry, S.R.: Prospective randomized study of a protein-based tissue adhesive used as a hemostatic and structural adjunct in cardiac and vascular anastomotic repair procedures. J. Am. Coll. Surg. 197(2), 243–252 (2003)

    Google Scholar 

  49. Tansley, P., Al-Mulhim, F., Lim, E., Ladas, G., Goldstraw, P.: A prospective, randomized, controlled trial of the effectiveness of BioGlue in treating alveolar air leaks. J. Thorac. Cardiovasc. Surg. 132(1), 105–112 (2006)

    Google Scholar 

  50. Fürst, W., Banerjee, A.: Release of glutaraldehyde from an albumin-glutaraldehyde tissue adhesive causes significant in vitro and in vivo toxicity. Ann. Thorac. Surg. 79, 1522–1529 (2005)

    Google Scholar 

  51. Fuller, C.: Reduction of intraoperative air leaks with progel in pulmonary resection: a comprehensive review. J. Cardiothorac. Surg. 8, 90 (2013)

    Google Scholar 

  52. Stone, W.M., Cull, D.L., Money, S.R.: A randomized prospective multicenter trial of a novel vascular sealant. Ann. Vasc. Surg. 26(8), 1077–1084 (2012)

    Google Scholar 

  53. Gilbert, T.W., Badylak, S.F., Gusenoff, J., Beckman, E.J., Clower, D.M., Daly, P., Rubin, J.P.: Lysine-derived urethane surgical adhesive prevents seroma formation in a canine abdominoplasty model. Plast. Reconstr. Surg. 122(1), 95–102 (2008)

    CAS  Google Scholar 

  54. Walgenbach, K.J., Bannasch, H., Kalthoff, S., Rubin, J.P.: Randomized, prospective study of TissuGlu® surgical adhesive in the management of wound drainage following abdominoplasty. Aesthetic Plast. Surg. 36(3), 491–496 (2012)

    Google Scholar 

  55. Öllinger, R., Mihaljevic, A.L., Schuhmacher, C., Bektas, H., Vondran, F., Kleine, M., Sainz-Barriga, M., Weiss, S., Knebel, P., Pratschke, J., Troisi, R.I.: A multicentre, randomized clinical trial comparing the Veriset™ haemostatic patch with fibrin sealant for the management of bleeding during hepatic surgery. HPB (Oxford) 15(7), 548–558 (2013)

    Google Scholar 

  56. Lauto, A., Mawad, D., Foster, L.J.R.: Review: adhesive biomaterials for tissue reconstruction. J. Chem. Tech. Biotech. 83, 464–472 (2008)

    CAS  Google Scholar 

  57. Singer, A.J., Thode, H.C.: A review of the literature on octylcyanoacrylate tissue adhesive. Am. J. Surg. 187, 238–248 (2004)

    CAS  Google Scholar 

  58. Singer, A.J., Perry, L.C., Allen Jr, R.L.: In vivo study of wound bursting strength and compliance of topical skin adhesives. Acad. Emerg. Med. 15(12), 1290–1294 (2008)

    Google Scholar 

  59. Jan, H., Waters, N., Haines, P., Kent, A.: LiquiBand® Surgical S topical adhesive versus sutures for the closure of laparoscopic wounds. A randomized controlled trial. Gynecol. Surg. 10, 247–252 (2013)

    Google Scholar 

  60. Bookland, M.J., Sukul, V., Connolly, P.J.: Use of a cyanoacrylate skin adhesive to reduce external ventricular drain infection rates. J. Neurosurg. (2014). doi:10.3171/2013.12.JNS13700

    Google Scholar 

  61. Ozer, M.T., Sinan, H., Saydam, M., Kilic, A., Akyol, M., Coskun, A.K., Bedir, O., Demibas, S.: Effectiveness of N-butyl cyanoacrylate-based microbial skin sealant on the prevention of surgical site infections. Surg. Infect. (Larchmt) 15(1), 14–17 (2014)

    Google Scholar 

  62. Osbun, J.W., Ellenbogen, R.G., Chesnut, R.M., Chin, L.S., Connolly, P.J., Cosgrove, G.R., Delashaw Jr, J.B., Golfinos, J.G., Greenlee, J.D., Haines, S.J., Jallo, J., Muizelaar, J.P., Nanda, A., Shaffrey, M., Shah, M.V., Tew Jr, J.M., van Loveren, H.R., Weinand, M.E., White, J.A., Wilberger, J.E.: A multicenter, single-blind, prospective randomized trial to evaluate the safety of a polyethylene glycol hydrogel (Duraseal Dural Sealant System) as a dural sealant in cranial surgery. World Neurosurg. 78(5), 498–504 (2012)

    Google Scholar 

  63. Glickman, M., Gheissari, A., Money, S., Martin, J., Ballard, J.L., CoSeal Multicenter Vascular Surgery Study Group: A polymeric sealant inhibits anastomotic suture hole bleeding more rapidly than gelfoam/thrombin: results of a randomized controlled trial. Arch. Surg. 137(3), 326–331 (2002)

    CAS  Google Scholar 

  64. Natour, E., Suedkamp, M., Dapunt, O.E.: Assessment of the effect on blood loss and transfusion requirements when adding a polyethylene glycol sealant to the anastomotic closure of aortic procedures: a case-control analysis of 102 patients undergoing Bentall procedures. J. Cardiothorac. Surg. 7, 105 (2012)

    Google Scholar 

  65. Lequaglie, C., Giudice, G., Marasco, R., Morte, A.D., Gallo, M.: Use of a sealant to prevent prolonged air leaks after lung resection: a prospective randomized study. J. Cardiothorac. Surg. 7, 106 (2012)

    Google Scholar 

  66. Ranger, W.R., Halpin, D., Sawhney, A.S., Lyman, M., LoCicero, J.: Pneumostasis of experimental air leaks with a new photopolymerized synthetic tissue sealant. Am. Surgeon 63, 788–795 (1997)

    CAS  Google Scholar 

  67. Lyman, M.L., Sawhney, A.S.: Design of a synthetic pneumosealant. Ann. Biomat. 2, 212 (1996)

    Google Scholar 

  68. Thompson, I.: TissuePatchTM3 and TissuePatchDuralTM: a review of constituent materials. Adhesive sealant biomaterials (2009)

    Google Scholar 

  69. Mandley, D.: Evaluation of a novel adhesive film for sealing air leaks after lung surgery. Adhesive sealant biomaterials (2009)

    Google Scholar 

  70. Zhang, R., Bures, M., Höffler, H.K., Zinne, N., Länger, F., Bisdas, T., Haverich, A., Krüger, M.: TissuePatch™ as a novel synthetic sealant for repair of superficial lung defect: in vitro tests results. Ann. Surg. Innov. Res. 6(1), 12 (2012)

    CAS  Google Scholar 

  71. Cheng, L., Lau, C.K., Parker, G.: Use of TissuePatch™ sealant film in the management of chyle leak in major neck surgery. Br. J. Oral. Maxillofac. Surg. 52(1), 87–89 (2014)

    Google Scholar 

  72. Iwasashi, M., Sakane, M., Saito, H., Taguchi, T., Tateishi, T., Ochiai, N.: In vivo evaluation of bonding ability and biocompatibility of a novel biodegradable glue consisting of tartaric acid derivative and human serum albumin. J. Biomed. Mater. Res. A 90(2), 543–548 (2009)

    Google Scholar 

  73. Elvin, C.M., Danon, S.J., Brownlee, A.G., White, J.F., Hickey, M., Liyou, N.E., Edwards, G.A., Ramshaw, J.A., Werkmeister, J.A.: Evaluation of photo-crosslinked fibrinogen as a rapid and strong tissue adhesive. J. Biomed. Mater. Res. A 93(2), 687–695 (2010)

    CAS  Google Scholar 

  74. Suzuki, S., Ikada, Y.: Sealing effects of crosslinked gelatin. J. Biomater. Appl. 27(7), 801–810 (2013)

    CAS  Google Scholar 

  75. LeMaire, S.A., Carter, S.A., Won, T., Wang, X., Conklin, L.D., Coselli, J.S.: The threat of adhesive embolization: BioGlue leaks through needle holes in aortic tissue and prosthetic grafts. Ann. Thorac. Surg. 80(1), 106–110 (2005)

    Google Scholar 

  76. Elvin, C.M., Vuocolo, T., Brownlee, A.G., Sando, L., Huson, M.G., Liyou, N.E., Stockwell, P.R., Lyons, R.E., Kim, M., Edwards, G.A., Johnson, G., McFarland, G.A., Ramshaw, J.A., Werkmeister, J.A.: A highly elastic tissue sealant based on photopolymerised gelatin. Biomaterials 31(32), 8323–8331 (2010)

    CAS  Google Scholar 

  77. Artzi, N., Shazly, T., Crespo, C., Ramos, A.B., Chenault, H.K., Edelman, E.R.: Characterization of star adhesive sealants based on PEG/dextran hydrogels. Macromol. Biosci. 11(9), 754–765 (2009)

    Google Scholar 

  78. Henderson, P.W., Kadouch, D.J., Singh, S.P., Zawaneh, P.N., Weiser, J., Yazdi, S., Weinstein, A., Krotscheck, U., Wechsler, B., Putnam, D., Spector, J.A.: A rapidly resorbable hemostatic biomaterial based on dihydroxyacetone. J. Biomed. Mater. Res. A 93(2), 776–782 (2010)

    Google Scholar 

  79. Horio, T., Ishihara, M., Fujita, M., Kishimoto, S., Kanatani, Y., Ishizuka, T., Nogami, Y., Nakamura, S., Tanaka, Y., Morimoto, Y., Maehara, T.: Effect of photocrosslinkable chitosan hydrogel and its sponges to stop bleeding in a rat liver injury model. Artif. Organs 34(4), 342–347 (2010)

    CAS  Google Scholar 

  80. Rickett, T.A., Amoozgar, Z., Tuchek, C.A., Park, J., Yeo, Y., Shi, R.: Rapidly photo-cross-linkable chitosan hydrogel for peripheral neurosurgeries. Biomacromolecules 12(1), 57–65 (2011)

    CAS  Google Scholar 

  81. Lauto, A., Mawad, D., Barton, M., Gupta, A., Piller, S.C., Hook, J.: Photochemical tissue bonding with chitosan adhesive films. Biomed. Eng. 9, 47 (2010)

    Google Scholar 

  82. Dowling, M.B., Kumar, R., Keibler, M.A., Hess, J.R., Bochicchio, G.V., Raghavan, S.R.: A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action. Biomaterials 32(13), 3351–3357 (2011)

    CAS  Google Scholar 

  83. Takaoka, M., Nakamura, T., Sugai, H., Bentley, A.J., Nakajima, N., Fullwood, N.J., Yokoi, N., Hyon, S.H., Kinoshita, S.: Sutureless amniotic membrane transplantation for ocular surface reconstruction with a chemically defined bioadhesive. Biomaterials 29(19), 2923–2931 (2008)

    CAS  Google Scholar 

  84. Cha, H.J., Hwang, D.S., Lim, S.: Development of bioadhesives from marine mussels. Biotechnol. J. 3, 631–635 (2008)

    CAS  Google Scholar 

  85. Lee, H., Lee, B.P., Messersmith, P.B.: A reversible wet/dry adhesive inspired by mussels and geckos. Nature 448, 338–341 (2007)

    CAS  Google Scholar 

  86. Waite, J.H., Tanzer, M.L.: Polyphenolic substance of mytilus edulis: novel adhesive containing L-Dopa and hydroxyproline. Science 212(4498), 1038–1040 (1981)

    CAS  Google Scholar 

  87. Dove, J., Sheridan, P.: Adhesive protein from mussles: possibilities for dentistry, medicine and industry. J. Am. Dent. Assoc. 112, 879 (1986)

    CAS  Google Scholar 

  88. Grande, D.A., Pitman, M.I.: The use of adhesives in chodrocyte transplantation surgery: preliminary studies. Bull. Hosp. Jt. Dis. Otrhop. Inst. 48, 140–148 (1988)

    CAS  Google Scholar 

  89. Saez, C., Pardo, J., Gutierrez, E., Brito, M., et al.: Immunological studies of the polyphenolic proteins of mussels. Comp. Biochem. Physiol. 98B, 569–572 (1991)

    CAS  Google Scholar 

  90. Lee, H., Dellatore, S.M., Miller, W.M., Messersmith, P.B.: Mussel-inspired surface chemistry for multifunctional coatings. Science 318, 426–430 (2007)

    CAS  Google Scholar 

  91. Shazly, T.M., Baker, A.B., Naber, J.R., Bon, A., Van Vliet, K.J., Edelman, E.R.: Augmentation of postswelling surgical sealant potential of adhesive hydrogels. J. Biomed. Mater. Res. A 95(4), 1159–1169 (2010)

    Google Scholar 

  92. Graham, L.D., Danon, S.J., Johnson, G., Braybrook, C., Hart, N.K., Varley, R.J., Evans, M.D., McFarland, G.A., Tyler, M.J., Werkmeister, J.A., Ramshaw, J.A.: Biocompatibility and modification of the protein-based adhesive secreted by the Australian frog Notaden bennetti. J. Biomed. Mater. Res. A 93(2), 429–441 (2010)

    Google Scholar 

  93. Aboushwareb, T., Eberli, D., Ward, C., Broda, C., Holcomb, J., Atala, A., Van Dyke, M.: A keratin biomaterial gel hemostat derived from human hair: evaluation in a rabbit model of lethal liver injury. J. Biomed. Mater. Res. B Appl. Biomater. 90(1), 45–54 (2009)

    Google Scholar 

  94. Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J.W., Chan, E.P., Carter, D.J., Bettinger, C.J., Patanavanich, S., Chignozha, L., Ben-Joseph, E., Galakatos, A., Pryor, H., Pomerantseva, I., Masiakos, P.T., Faquin, W., Zumbuehl, A., Hong, S., Borenstein, J., Vacanti, J., Langer, R., Karp, J.M.: A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc. Natl. Acad. Sci. USA 105(7), 2307–2312 (2008)

    CAS  Google Scholar 

  95. Liakakos, T., Thomakos, N., Fine, P.M., Dervenis, C., Young, R.L.: Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig. Surg. 18(4), 260–273 (2001)

    CAS  Google Scholar 

  96. Robertson, D., Lefebvre, G., Leyland, N., Wolfman, W., Allaire, C., Awadalla, A., Best, C., Contestabile, E., Dunn, S., Heywood, M., Leroux, N., Potestio, F., Rittenberg, D., Senikas, V., Soucy, R., Singh, S.: Society of obstetricians and gynaecologists of canada, adhesion prevention in gynaecological surgery. J. Obstet. Gynaecol. Can. 32(6), 598–608 (2010)

    Google Scholar 

  97. Poole, J.H.: Adhesions following cesarean delivery: a review of their occurrence, consequences and preventative management using adhesion barriers. Womens Health (Lond. Engl.) 9(5), 467–477 (2013)

    CAS  Google Scholar 

  98. Kamel, R.M.: Prevention of postoperative peritoneal adhesions. Eur. J. Obstet. Gynecol. Reprod. Biol. 150(2), 111–118 (2010)

    Google Scholar 

  99. Novitsky, Y.W., Harrell, A.G., Cristiano, J.A., Paton, B.L., Norton, H.J., Peindl, R.D., Kercher, K.W., Heniford, B.T.: Comparative evaluation of adhesion formation, strength of ingrowth, and textile properties of prosthetic meshes after long-term intra-abdominal implantation in a rabbit. J. Surg. Res. 140(1), 6–11 (2007)

    CAS  Google Scholar 

  100. Larsson, B., Lalos, O., Marsk, L., Tronstad, S.E., Bygdeman, M., Pehrson, S., Joelsson, I.: Effect of intraperitoneal instillation of 32 % dextran 70 on postoperative adhesion formation after tubal surgery. Acta Obstet. Gynecol. Scand. 64(5), 437–441 (1985)

    CAS  Google Scholar 

  101. Weinans, M.J., Kauer, F.M., Klompmaker, I.J., Wijma, J.: Transient liver function disturbances after the intraperitoneal use of 32 % dextran 70 as adhesion prophylaxis in infertility surgery. Fertil. Steril. 53(1), 159–161 (1990)

    CAS  Google Scholar 

  102. Tulandi, T.: Transient edema after intraperitoneal instillation of 32 % dextran 70. A report of five cases. J. Reprod. Med. 32(6), 472–474 (1987)

    CAS  Google Scholar 

  103. Sites, C.K., Jensen, B.A., Glock, J.L., Blackman, J.A., Badger, G.J., Johnson, J.V., Brumsted, J.R.: Transvaginal ultrasonographic assessment of hyskon or lactated ringer’s solution instillation after laparoscopy: randomized, controlled study. J. Ultrasound Med. 16(3), 195–199 (1997)

    CAS  Google Scholar 

  104. Holtz, G., Baker, E., Tsai, C.: Effect of thirty-two per cent dextran 70 on peritoneal adhesion formation and re-formation after lysis. Fertil. Steril. 33(6), 660–662 (1980)

    CAS  Google Scholar 

  105. Rose, B.: Safety of Hyskon for routine gynecologic surgery. A case report. J. Reprod. Med. 32(2) (1987)

    Google Scholar 

  106. Ruiz, J.M., Neuwirth, R.F.: The incidence of complications associated with the use of hyskon during hysteroscopy: experience in 1793 consecutive patients. J. Gynecol. Surg. 8(4), 219–224 (1992)

    Google Scholar 

  107. Kossi, J., Gronlund, S., Uotila-Nieminen, M., Crowe, A., Knight, A., Keranen, U.: The effect of 4 % icodextrin solution on adhesiolysis surgery time at the Hartmann’s reversal: a pilot, multicentre, randomized control trial vs lactated Ringer’s solution. Colorectal Dis. 11, 168–172 (2008)

    Google Scholar 

  108. Johns, D.B., Keyport, G.M., Hoehler, F., diZerega, G.S.: Reduction of postsurgical adhesions with intergel® adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil. Steril. 76(3), 595–604 (2001)

    CAS  Google Scholar 

  109. FDA: Safety alert—INTERGEL adhesion prevention solution. (2003) Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm170010.htm

  110. Rice, V.M., Shanti, A., Moghissi, K.S., Leach, R.E.: A comparative evaluation of Poloxamer 407 and oxidized regenerated cellulose (Interceed [TC7]) to reduce postoperative adhesion formation in the rat uterine horn model. Fertil. Steril. 59(4), 901–906 (1993)

    CAS  Google Scholar 

  111. Weis, C., Odermatt, E.: A-Part Gel—an efficient adheison prevention barrier. J. Biomed. Mater. Res. B Appl. Biomater. 82B, 174–182 (2006)

    Google Scholar 

  112. Weis, C., Odermatt, E.K., Kressler, J., Funke, Z., Wehner, T., Freytag, D.: Poly(vinyl alcohol) membrane for adhesion prevention. J. Biomed. Mater. Res. 70B, 191–202 (2004)

    CAS  Google Scholar 

  113. Janigen, B., Weis, C., Odermatt, E.K., Obermaier, R., Hopt, U.T.: The new adhesion prophylaxis membrane A-Part-from in vitro testing to first in vivo results. J. Biomed. Mater. Res. 89B, 293–299 (2009)

    Google Scholar 

  114. Jaenigen, B.M., Weis, C., Odermatt, E.K., Hopt, U.T., Obermaier, R.: The new adhesion prophylaxis membrane A-part–from in vitro testing to first in vivo results. J. Biomed. Mater. Res. B Appl. Biomater. 89(2), 293–299 (2009)

    Google Scholar 

  115. Lang, R.A., Weisgerber, C., Grüntzig, P.M., Weis, C., Odermatt, E.K., Kirschner, M.H.: Polyvinyl alcohol gel prevents adhesion re-formation after adhesiolysis in a rabbit model. J. Surg. Res. 153(3), 12–16 (2009)

    CAS  Google Scholar 

  116. Slieker, J.C., Ditzel, M., Harlaar, J.J., Mulder, I.M., Deerenberg, E.B., Bastiaansen-Jenniskens, Y.M., Kleinrensink, G.J., Jeekel, J., Lange, J.F.: Effects of new anti-adhesion polyvinyl alcohol gel on healing of colon anastomoses in rats. Surg. Infect. (Larchmt) 13(6), 396–400 (2012)

    Google Scholar 

  117. Young, P., Johns, A., Templeman, C., Witz, C., Webster, B., Ferland, R., Diamond, M.P., Block, K., diZerega, G.: Reduction of postoperative adhesions after laparoscopic gynecological surgery with Oxiplex/AP Gel: a pilot study. Fertil. Steril. 84(5), 1450–1456 (2005)

    Google Scholar 

  118. Mettler, L., Audebert, A., Lehmann-Willenbrock, E., Jacobs, V.R., Schive, K.: New adhesion prevention concept in gynecological surgery. JSLS 7(3), 207–209 (2003)

    CAS  Google Scholar 

  119. Mettler, L., Audebert, A., Lehmann-Willenbrock, E., Schive, K., Jacobs, V.R.: Prospective clinical trial of SprayGel as a barrier to adhesion formation: an interim analysis. J. Am. Assoc. Gynecol. Laparosc. 10(3), 339–344 (2003)

    CAS  Google Scholar 

  120. Tjandra, J.J., Chan, M.K.: A sprayable hydrogel adhesion barrier facilitates closure of defunctioning loop ileostomy: a randomized trial. Dis. Colon Rectum. 51(6), 956–960 (2008)

    Google Scholar 

  121. Ferland, R., Campbell, P.K.: Evaluation of SprayShield adhesion barrier system in a porcine model of gynecological surgery. Covidien AG (2008)

    Google Scholar 

  122. Mettler, L., Sammur, W., Schollmeyer, T., Alkatout, I.: Cross-linked sodium hyaluronate, an anti-adhesion barrier gel in gynaecological endoscopic surgery. Minim. Invasive Ther. Allied Technol. 22(5), 260–265 (2013)

    Google Scholar 

  123. Mettler, L.: Effect of cross linked sodium hyaluronate in adhesion reduction within the gynecologic surgical window. OJOG 4, 120–129 (2014)

    CAS  Google Scholar 

  124. The Myomectomy Adhesion Multicenter Study Group: An expanded polytetrafluoroethylene barrier (Gore-Tex Surgical Membrane) reduces post-myomectomy adhesion formation. Fertil. Steril. 3(3), 491–493 (1995)

    Google Scholar 

  125. Haney, A.F., Hesla, J., Hurst, B.S., Kettel, L.M., Murphy, A.A., Rock, J.A., Rowe, G., Schlaff, W.D.: Expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) in preventing adhesions. Fertil. Steril. 63(5), 1021–1026 (1995)

    CAS  Google Scholar 

  126. Kawamura, H., Yokota, R., Yokota, K., Watarai, H., Tsunoda, Y., Yamagami, H., Hata, T., Tanaka, K., Masuko, H., Ishizu, H., Okada, K., Adachi, T., Kondo, Y.: A sodium hyaluronate carboxymethylcellulose bioresorbable membrane prevents postoperative small-bowel adhesive obstruction after distal gastrectomy. Surg. Today 40, 223–227 (2010)

    CAS  Google Scholar 

  127. Becker, J.M., Dayton, M.T., Fazio, V.W., Beck, D.E., Stryker, S.J., Wexner, S.D., Wolff, B.G., Roberts, P.L., Smith, L.E., Sweeney, S.A., Moore, M.: Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J. Am. Coll. Surg. 183(4), 297–306 (1996)

    CAS  Google Scholar 

  128. Kusunoki, M., Ikeuchi, H., Yanagi, H., Noda, M., Tonouchi, H., Mohri, Y., Uchida, K., Inoue, Y., Kobayashi, M., Miki, C., Yamamura, T.: Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg. Today 35(11), 940–945 (2005)

    Google Scholar 

  129. Hayashi, S., Takayama, T., Masuda, H., Kochi, M., Ishii, Y., Matsuda, M., Yamagata, M., Fujii, M.: Bioresorbable membrane to reduce postoperative small bowel obstruction in patients with gastric cancer: a randomized clinical trial. Ann. Surg. 247(5), 766–770 (2008)

    Google Scholar 

  130. Beck, D.E., Cohen, Z., Fleshman, J.W., Kaufman, H.S., van Goor, H., Wolff, B.G., Adhesion Study Group Steering Committee: A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis. Colon Rectum. 46(10), 1310–1319 (2003)

    Google Scholar 

  131. Fazio, V.W., Cohen, Z., Fleshman, J.W., van Goor, H., Bauer, J.J., Wolff, B.G., Corman, M., Beart Jr, R.W., Wexner, S.D., Becker, J.M., Monson, J.R., Kaufman, H.S., Beck, D.E., Bailey, H.R., Ludwig, K.A., Stamos, M.J., Darzi, A., Bleday, R., Dorazio, R., Madoff, R.D., Smith, L.E., Gearhart, S., Lillemoe, K., Gohl, J.: Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis. Colon Rectum. 49(1), 1–11 (2006)

    Google Scholar 

  132. Diamond, M.P., Burns, E.L., Accomando, B., Mian, S., Holmdahl, L.: Seprafilm®adhesion barrier: (1) a review of preclinical, animal, and human investigational studies. Cynecol. Surg. 9, 237–245 (2012)

    Google Scholar 

  133. Diamond, M.P., Burns, E.L., Accomando, B., Mian, S., Holmdahl, L.: Seprafilm® adhesion barrier: (2) a review of the clinical literature on intraabdominal use. Gynecol. Surg. 9, 247–257 (2012)

    Google Scholar 

  134. Walther, T., Rastan, A., Dähnert, I., Falk, V., Jacobs, S., Mohr, F.W., Kostelka, M.: A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery. J. Thorac. Cardiovasc. Surg. 129(2), 359–363 (2005)

    Google Scholar 

  135. Wiseman, D.M., Trout, J.R., Franklin, R.R., Diamond, M.P.: Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. J. Reprod. Med. 44(4), 325–331 (1999)

    CAS  Google Scholar 

  136. INTERCEED(TC7) Adhesion Barrier Study Group: Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. Fertil. Steril. 51(6), 933–938 (1989)

    Google Scholar 

  137. Faerden, A., Reiertsen, O., Marx, A.: The effectiveness of a bioresorbable polymer sheet (SurgiWrap®) in minimizing soft tissue attachments (STA) after major colorectal surgery: a randomized controlled pilot study. MAST Biosurgery from manufactures website. (2006)

    Google Scholar 

  138. Lodge, A.J., Wells, W.J., Backer, C.L., O’Brien Jr, J.E., Austin, E.H., Bacha, E.A., Yeh Jr, T., Decampli, W.M., Lavin, P.T., Weinstein, S.: A novel bioresorbable film reduces postoperative adhesions after infant cardiac surgery. Ann. Thorac. Surg. 86(2), 614–621 (2008)

    Google Scholar 

  139. Gagnieu, C.H., Forest, P.O.: In vivo biodegradability and biocompatibility of porcine type I atelocollagen newly crosslinked by oxidized glycogen. Biomed. Mater. Eng. 17(1), 9–18 (2007)

    CAS  Google Scholar 

  140. Bel, A., Kachatryan, L., Bruneval, P., Peyrard, S., Gagnieu, C., Fabiani, J.N., Menasché, P.: A new absorbable collagen membrane to reduce adhesions in cardiac surgery. Interact. CardioVasc. Thorac. Surg. 10(2), 213–216 (2010)

    Google Scholar 

  141. Diamond, M.P., Kruger, M., Saed, G.M.: Effect of tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1. Fertil. Steril. 81, 1657–1664 (2004)

    CAS  Google Scholar 

  142. Prieto-Díaz-Chávez, E., Medina-Chávez, J.L., Ramírez-Barba, E.J., Trujillo-Hernández, B., Millán-Guerrero, R.O., Vásquez, C.: Reduction of peritoneal adhesion to polypropylene mesh with the application of fibrin glue. Acta Chir. Belg. 108, 433–437 (2008)

    Google Scholar 

  143. Martín-Cartes, J.A., Morales-Conde, S., Suárez-Grau, J.M., Bustos-Jiménez, M., Cadet-Dussort, J.M., López-Bernal, F., Morcillo-Azcárate, J., Tutosaus-Gómez, J.D., Morales-Méndez, S.: Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair. Surg. Today 38(2), 135–140 (2008)

    Google Scholar 

  144. Petter-Puchner, A.H., Walder, N., Redl, H., Schwab, R., Ohlinger, W., Gruber-Blum, S., Fortelny, R.H.: Fibrin sealant (Tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intraabdominal peritoneal onlay mesh repair. J. Surg. Res. 150(2), 190–195 (2008)

    CAS  Google Scholar 

  145. Frykman, E., Jacobsson, S., Widenfalk, B.: Fibrin sealant in prevention of flexor tendon adhesions: an experimental study in the rabbit. J. Hand. Surg. 18A, 68–75 (1993)

    Google Scholar 

  146. Yoshioka, I., Saiki, Y., Sakuma, K., Iguchi, A., Moriya, T., Ikada, Y., Tabayashi, K.: Bioabsorbable gelatin sheets latticed with polyglycolic acid can eliminate pericardial adhesion. Ann. Thorac. Surg. 84, 864–870 (2007)

    Google Scholar 

  147. Sakuma, K., Iguchi, A., Ikada, Y., Tabayashi, K.: Closure of the pericardium using synthetic bioabsorbable polymers. Ann. Thorac. Surg. 80, 1835–1840 (2005)

    Google Scholar 

  148. Bae, S.H., Son, S.R., Kumar Sakar, S., Nguyen, T.H., Kim, S.W., Min, Y.K., Lee, B.T.: Evaluation of the potential anti-adhesion effect of the PVA/Gelatin membrane. J. Biomed. Mater. Res. B Appl. Biomater. 102(4), 840–849 (2014)

    Google Scholar 

  149. Vorvolakos, K., Isayeva, I.S., Luu, H.-M.D., Patwardhan, D.V., Pollack, S.K.: Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel. Medical Devices Evidence Res. 2011(4), 1–10 (2010)

    Google Scholar 

  150. Nilsson, E., Björn, C., Sjöstrand, V., Lindgren, K., Münnich, M., Mattsby-Baltzer, I., Ivarsson, M.L., Olmarker, K., Mahlapuu, M.: A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat. Ann. Surg. 250(6), 1021–1028 (2009)

    Google Scholar 

  151. Lauder, C.I., Garcea, G., Strickland, A., Maddern, G.J.: Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model. J. Surg. Res. (2010) (Epub ahead of print)

    Google Scholar 

  152. Falabella, C.A., Melendez, M.M., Weng, L., Chen, W.: Novel macromolecular crosslinking hydrogel to reduce intra-abdominal adhesions. J. Surg. Res. 159(2), 772–778 (2010)

    CAS  Google Scholar 

  153. Li, L., Wang, N., Jin, X., Deng, R., Nie, S., Sun, L., Wu, Q., Wei, Y., Gong, C.: Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention. Biomaterials 35(12), 3903–3917 (2014)

    CAS  Google Scholar 

  154. Pätilä, T., Jokinen, J.J., Salminen, J., Kankuri, E., Harjula, A.: Polyglycolic acid glue does not prevent intrapericardial adhesions in a short-term follow-up. J. Surg. Res. 148(2), 181–184 (2008)

    Google Scholar 

  155. Yang, B., Gong, C.Y., Qian, Z.Y., Zhao, X., Li, Z.Y., Zhou, S.T., Qi, X.R., Zhong, Q., Luo, F., Wei, Y.Q.: Prevention of abdominal adhesion formation by thermosensitive PECE-hydrogel in a rat uterine horn model. J. Biomed. Mater. Res. B Appl. Biomater. 96(1), 57–66 (2011)

    Google Scholar 

  156. Yang, B., Gong, C., Zhao, X., Zhou, S., Li, Z., Qi, X., Zhong, Q., Luo, F., Qian, Z.: Preventing postoperative abdominal adhesions in a rat model with PEG-PCL-PEG hydrogel. Int. J. Nanomed. 7, 547–557 (2012)

    CAS  Google Scholar 

  157. Niwa, D., Koide, M., Fujie, T., Goda, N., Takeoka, S.: Application of nanosheets as an anti-adhesion barrier in partial hepatectomy. J. Biomed. Mater. Res. B Appl. Biomater. 101(7), 1251–1258 (2013)

    Google Scholar 

  158. Wang, H., Li, M., Hu, J., Wang, C., Xu, S., Han, C.C.: Multiple targeted drugs carrying biodegradable membrane barrier: anti-adhesion, hemostasis, and anti-infection. Biomacromolecules 14(4), 954–961 (2013)

    CAS  Google Scholar 

  159. Pryor, H.I., O’Doherty, E., Hart, A., Owens, G., Hoganson, D., Vacanti, J.P., Masiakos, P.T., Sundback, C.A.: Poly(glycerol sebacate) films prevent postoperative adhesions and allow laparoscopic placement. Surgery 146, 490–497 (2009)

    Google Scholar 

  160. Lee, M.W., Tsai, H.F., Wen, S.M., Huang, C.H.: Photocrosslinkable gellan gum film as an anti-adhesion barrier. Carbohydr. Polym. 90(2), 1132–1138 (2012)

    CAS  Google Scholar 

  161. Firestone, D.E., Lauder, A.J.: Chemistry and mechanics of commonly used sutures and needles. J. Hand. Surg. Am. 35, 486–488 (2010)

    Google Scholar 

  162. Allmeling, C., Jokuszies, A., Reimers, K., Kall, S., Choi, C.Y., Brandes, G., Kasper, C., Scheper, T., Guggenheim, M., Vogt, P.M.: Spider silk fibres in artificial nerve constructs promote peripheral nerve regeration. Cell Prolif. 41, 408–420 (2008)

    CAS  Google Scholar 

  163. Allmeling, C., Jokuszies, A., Reimers, K., Kall, S., Vogt, P.M.: Use of spider silk fibres as an innovative material in a biocompatible artificial nerve coduit. J. Cell Mol. Med. 10, 770–777 (2006)

    Google Scholar 

  164. Kuhbier, J.W., Reimers, K., Kasper, C., Allmeling, C., Hillmer, A., Menger, B., Vogt, P.M., Radtke, C.: First investigation of spider silk as a braided microsurgical suture. J. Biomed. Mater. Res. B Appl. Biomater. 97, 381–387 (2011)

    Google Scholar 

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Authors and Affiliations

  1. Queensland Eye Institute, 140 Melbourne Street, South Brisbane, QLD 4101, Australia

    Shuko Suzuki

  2. Emeritus Professor of Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Yoshito Ikada

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    Francesco Puoci

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Suzuki, S., Ikada, Y. (2015). Polymers for Surgery. In: Puoci, F. (eds) Advanced Polymers in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-12478-0_8

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