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Transplantation-associated arteriosclerosis and inflammation

  • Chapter
Inflammatory and Infectious Basis of Atherosclerosis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Transplantation-associated arteriosclerosis (TAA), a complication of allotransplantation, remains the major limitation to the long-term survival of many solid organ transplant recipients. Over the last decade, particularly, our understanding of the pathogenesis of TAA grew significantly. Morphological, immunohistochemical, and molecular studies performed on human tissues combined with an expanding clinical, radiological and epidemiological database have improved our knowledge of the cellular and biochemical events that culminate in TAA. Studies using innovative animal models have added to what has been gleaned from the human studies, and allowed for trials of unique therapeutic strategies. Nonetheless, for cardiac transplant recipients, TAA continues to be the largest single cause of death after the first year post-transplantation [1]. Arteriosclerosis is also a feature of chronic renal transplant rejection [2] and chronic pulmonary allograft rejection [3], though in lung allografts it appears to be unassociated with any physiological consequences [4]. Since much of the literature regarding TAA focuses upon its manifestations in the transplanted heart, the following discussion will concentrate primarily upon TAA developing in cardiac allografts, also known as cardiac allograft vasculopathy (CAV).

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References

  1. Hosenpud JD, Bennett LE, Keck BM, Fiol B, Boucek MM, Novick RJ (1998) The Registry of the International Society for Heart and Lung Transplantation: fifteenth official report 1998.J Heart Lung Transplant17: 656–668

    PubMed  CAS  Google Scholar 

  2. Racusen LC, Solez K, Colvin RB, Bonsib SM, Castro MC, Cavallo T, Croker BP, Demetris AJ, Drachenberg CB, Fogo AB et al (1999) The Banff 97 working classification of renal allograft pathology.Kidney Int55: 713–723

    Article  PubMed  CAS  Google Scholar 

  3. Yousem SA, Berry GJ, Cagle PT, Chamberlain D, Husain AN, Hruban RH, Marchevsky A, Ohori NP, Ritter J, Stewart S et al (1996) Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group.J Heart Lung Transplant15: 1–15

    PubMed  CAS  Google Scholar 

  4. Yousem SA, Paradis IL, Dauber JH, Zeevi A, Duquesnoy RJ, Dal CR, Armitage J, Hardesty RL, Griffith BP (1989) Pulmonary arteriosclerosis in long-term human heart-lung transplant recipients.Transplantation47: 564–569

    Article  PubMed  CAS  Google Scholar 

  5. Billingham ME (1994) Pathology and etiology of chronic rejection of the heart.Clin Transplant8: 289–292

    PubMed  CAS  Google Scholar 

  6. Wahlers T, Fieguth HG, Jurmann M, Albes J, Hausen B, Demertzis S, Schafers HJ, Oppelt P, Mugge A, Borst HG (1996) Graft coronary vasculopathy in cardiac transplantation — evaluation of risk factors by multivariate analysis.Eur J Cardiothorac Surg 10:1–5

    Article  PubMed  CAS  Google Scholar 

  7. Uretsky BF, Murali S, Reddy PS, Rabin B, Lee A, Griffith BP, Hardesty RL, Trento A, Bahnson HT (1987) Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone.Circulation76: 827–834

    Article  PubMed  CAS  Google Scholar 

  8. Gao SZ, Schroeder JS, Alderman EL, Hunt SA, Valantine HA, Wiederhold V, Stinson EB (1989) Prevalence of accelerated coronary artery disease in heart transplant survivors. Comparison of cyclosporine and azathioprine regimens.Circulation80: III100–III105

    PubMed  CAS  Google Scholar 

  9. Haverich A, Costard-Jackle A, Cremer J, Herrmann G, Simon R (1994) Cyclosporin A and transplant coronary disease after heart transplantation: Facts and fiction.TransplantProc 26: 2713–2715

    PubMed  CAS  Google Scholar 

  10. Bailey LL, Zuppan CW, Chinnock RE, Johnston JK, Razzouk AJ, Gundry SR (1995) Graft vasculopathy among recipients of heart transplantation during the first 12 years of life. The Pediatric Heart Transplant Group.Transplant Proc27: 1921–1925

    PubMed  CAS  Google Scholar 

  11. Pahl E, Fricker FJ, Armitage J, Griffith BP, Taylor S, Uretsky BF, Beerman LB, Zuberbuhler JR (1990) Coronary arteriosclerosis in pediatric heart transplant survivors: limitation of long-term survival.J Pediatr116: 177–183

    Article  PubMed  CAS  Google Scholar 

  12. Hornick P, Smith J, Pomerance A, Mitchell A, Banner N, Rose M, Yacoub M (1997) Influence of acute rejection episodes, HLA matching, and donor/recipient phenotype on the development of `early’ transplant-associated coronary artery disease.Circulation 96(9 Suppl): II-148–153

    Google Scholar 

  13. Liu G, Butany J (1992) Morphology of graft arteriosclerosis in cardiac transplant recipients.Hum Pathol23: 768–773

    Article  PubMed  CAS  Google Scholar 

  14. Costanzo NM (1992) Cardiac allograft vasculopathy: relationship with acute cellular rejection and histocompatibility.J Heart Lung Transplant 11:S90–103

    Google Scholar 

  15. Opelz G, Wujciak T (1994) The influence of HLA compatibility on graft survival after heart transplantation. The Collaborative Transplant Study.N Engl J Med330: 816–819

    Article  PubMed  CAS  Google Scholar 

  16. Smith JD, Rose ML, Pomerance A, Burke M, Yacoub MH (1995) Reduction of cellular rejection and increase in longer-term survival after heart transplantation after HLA-DR matching [see comments].Lancet346: 1318–1322

    Article  PubMed  CAS  Google Scholar 

  17. Costanzo MR (1995) The role of histoincompatibility in cardiac allograft vasculopathy.J Heart Lung Transplant14: S180–S184

    PubMed  CAS  Google Scholar 

  18. Rose EA, Smith CR, Petrossian GA, Barr ML, Reemtsma K (1989) Humoral immune responses after cardiac transplantation: correlation with fatal rejection and graft atherosclerosis.Surgery106: 203–207

    PubMed  CAS  Google Scholar 

  19. Escobar A, Ventura HO, Stapleton DD, Mehra MR, Ramee SR, Collins TJ, Jain SP, Smart FW, White CJ (1994) Cardiac allograft vasculopathy assessed by intravascular ultrasonography and nonimmunologic risk factors. AmJ Cardiol74: 1042–1046

    Article  PubMed  CAS  Google Scholar 

  20. Eich D, Thompson JA, Ko DJ, Hastillo A, Lower R, Katz S, Katz M, Hess ML (1991) Hypercholesterolemia in long-term survivors of heart transplantation: an early marker of accelerated coronary artery disease.J Heart Lung Transplant 10:45–49

    PubMed  CAS  Google Scholar 

  21. Hess ML, Hastillo A, Mohanakumar T, Cowley MJ, Vetrovac G, Szentpetery S, Wolfgang TC, Lower RR (1983) Accelerated atherosclerosis in cardiac transplantation: role of cytotoxic B-cell antibodies and hyperlipidemia.Circulation68: II94–101

    PubMed  CAS  Google Scholar 

  22. Barbir M, Kushwaha S, Hunt B, Macken A, Thompson GR, Mitchell A, Robinson D, Yacoub M (1992) Lipoprotein(a) and accelerated coronary artery disease in cardiac transplant recipients.Lancet340: 1500–1502

    Article  PubMed  CAS  Google Scholar 

  23. Valantine HA (1995) Role of lipids in allograft vascular disease: a multicenter study of intimal thickening detected by intravascular ultrasound.J Heart Lung Transplant14: S234–S237

    PubMed  CAS  Google Scholar 

  24. Koskinen P, Lemstrom K, Mattila S, Hayry P, Nieminen MS (1996) Cytomegalovirus infection associated accelerated heart allograft arteriosclerosis may impair the late function of the graft.Clin Transplant10: 487–493

    PubMed  CAS  Google Scholar 

  25. Everett JP, Hershberger RE, Norman DJ, Chou S, Ratkovec RM, Cobanoglu A, Ott GY, Hosenpud JD (1992) Prolonged cytomegalovirus infection with viremia is associated with development of cardiac allograft vasculopathy.J Heart Lung Transplant11: S133–S137

    PubMed  CAS  Google Scholar 

  26. Grattan MT, Moreno CC, Starnes VA, Oyer PE, Stinson EB, Shumway NE (1989) Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis.JAMA261: 3561–3566

    Article  PubMed  CAS  Google Scholar 

  27. Costanzo NM, Swinnen LJ, Fisher SG, O’Sullivan EJ, Pifarre R, Heroux AL, Mullen GM, Johnson MR (1992) Cytomegalovirus infections in heart transplant recipients: relationship to immunosuppression [see comments].J Heart Lung Transplant11: 837–846

    Google Scholar 

  28. Nadasdy T, Smith J, Laszik Z, Waner JL, Johnson LD, Silva FG (1994) Absence of association between cytomegalovirus infection and obliterative transplant arteriopathy in renal allograft rejection.Mod Pathol7: 289–294

    PubMed  CAS  Google Scholar 

  29. Sharpies LD, Caine N, Mullins P, Scott JP, Solis E, English TA, Large SR, Schofield PM, Wallwork J (1991) Risk factor analysis for the major hazards following heart transplantation — rejection, infection, and coronary occlusive disease.Transplantation52: 244–252

    Article  Google Scholar 

  30. Billingham ME (1992) Histopathology of graft coronary disease.J Heart Lung Transplant 11:S38–S44

    PubMed  CAS  Google Scholar 

  31. Johnson DE, Gao SZ, Schroeder JS, DeCampli WM, Billingham ME (1989) The spectrum of coronary artery pathologic findings in human cardiac allografts.J Heart Transplant8: 349–359

    PubMed  CAS  Google Scholar 

  32. Kosek JC, Bieber C, Lower RR (1971) Heart graft arteriosclerosis.Transplant Proc3: 512–514

    PubMed  CAS  Google Scholar 

  33. Uys CJ, Rose AG (1984) Pathologic findings in long-term cardiac transplants.Arch Pathol Lab Med108: 112–116

    PubMed  CAS  Google Scholar 

  34. Bieber CP, Stinson EB, Shumway NE, Payne R, Kosek J (1970) Cardiac transplantation in man. VII. Cardiac allograft pathology.Circulation41: 753–772

    Article  PubMed  CAS  Google Scholar 

  35. Rose AG, Viviers L, Odell JA (1993) Pathology of chronic cardiac rejection: An analysis of epicardial and intramyocardial coronary arteries and myocardial alterations in 43 human allografts.Cardiovasc Pathol2: 7–19

    Article  Google Scholar 

  36. Oni AA, Ray J, Hosenpud JD (1992) Coronary venous intimai thickening in explanted cardiac allografts. Evidence demonstrating that transplant coronary artery disease is a manifestation of a diffuse allograft vasculopathy.Transplantation53: 1247–1251

    Article  PubMed  CAS  Google Scholar 

  37. Winters GL, Schoen FJ (1997) Graft arteriosclerosis-induced myocardial pathology in heart transplant recipients: predictive value of endomyocardial biopsy.J Heart Lung Transplant16: 985–993

    PubMed  CAS  Google Scholar 

  38. Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P (1991) Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.Am J Pathol138: 791–798

    PubMed  CAS  Google Scholar 

  39. Rose ML (1998) Endothelial cells as antigen-presenting cells: role in human transplant rejection.Cell Mol Life Sci54: 965–978

    Article  PubMed  CAS  Google Scholar 

  40. Hruban RH, Beschorner WE, Baumgartner WA, Augustine SM, Ren H, Reitz BA, Hutchins GM (1990) Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis.Am J Pathol137: 871–882

    PubMed  CAS  Google Scholar 

  41. Raisanen SA, Glysing JT, Mottram PL, Russell ME (1997) Sustained anti-CD4/CD8 treatment blocks inflammatory activation and intimai thickening in mouse heart allografts.Arterioscler Thromb Vasc Biol17: 2115–2122

    Article  Google Scholar 

  42. Shi C, Lee WS, He Q, Zhang D, Fletcher DL Jr, Newell JB, Haber E (1996) Immunologic basis of transplant-associated arteriosclerosis.Proc Natl Acad Sci USA93: 4051–4056

    Article  PubMed  CAS  Google Scholar 

  43. Russell ME, Hancock WW, Akalin E, Wallace AF, Glysing JT, Willett TA, Sayegh MH (1996) Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28–B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.J Clin Invest97: 833–838

    Article  PubMed  CAS  Google Scholar 

  44. Glysing JT, Raisanen SA, Sayegh MH, Russell ME (1997) Chronic blockade of CD28B7-mediated T-cell costimulation by CTLA4Ig reduces intimai thickening in MHC class I and II incompatible mouse heart allografts.Transplantation64: 1641–1645

    Article  Google Scholar 

  45. Azuma H, Chandraker A, Nadeau K, Hancock WW, Carpenter CB, Tilney NL, Sayegh MH (1996) Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection [see comments].Proc Natl Acad Sci USA93: 12439–12444

    Article  CAS  Google Scholar 

  46. Salom RN, Maguire JA, Hancock WW (1998) Endothelial activation and cytokine expression in human acute cardiac allograft rejection.Pathology30: 24–29

    Article  PubMed  CAS  Google Scholar 

  47. Dong C, Wilson JE, Winters GL, McManus BM (1996) Human transplant coronary artery disease: pathological evidence for Fas-mediated apoptotic cytotoxicity in allograft arteriopathy.Lab Invest74: 921–931

    PubMed  CAS  Google Scholar 

  48. Fox WM, Hameed A, Hutchins GM, Reitz BA, Baumgartner WA, Beschorner WE, Hruban RH (1993) Perforin expression localizing cytotoxic lymphocytes in the intimas of coronary arteries with transplant-related accelerated arteriosclerosis.Hum Pathol24: 477–482

    Article  PubMed  Google Scholar 

  49. Hancock WW, Buelow R, Sayegh MH, Turka LA (1998) Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes.Nat Med4: 1392–1396

    Article  PubMed  CAS  Google Scholar 

  50. Russell PS, Chase CM, Colvin RB (1995) Coronary atherosclerosis in transplanted mouse hearts. IV Effects of treatment with monoclonal antibodies to intercellular adhesion molecule-1 and leukocyte function-associated antigen-1.Transplantation60: 724–729

    Article  PubMed  CAS  Google Scholar 

  51. Suzuki J, Isobe M, Yamazaki S, Horie S, Okubo Y, Sekiguchi M (1997) Inhibition of accelerated coronary atherosclerosis with short-term blockade of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in a heterotopic murine model of heart transplantation.J Heart Lung Transplant16: 1141–1148

    PubMed  CAS  Google Scholar 

  52. Poston RS, Ennen M, Pollard J, Hoyt EG, Billingham ME, Robbins RC (1998) Ex vivo gene therapy prevents chronic graft vascular disease in cardiac allografts.J Thorac Cardiovasc Surg116: 386–396

    Article  PubMed  CAS  Google Scholar 

  53. Koskinen PK, Lemstrom KB (1997) Adhesion molecule P-selectin and vascular cell adhesion molecule-1 in enhanced heart allograft arteriosclerosis in the rat.Circulation95: 191–196

    Article  PubMed  Google Scholar 

  54. Korom S, Hancock WW, Coito AJ, Kupiec WJ (1998) Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients. II. Treatment with connecting seg-ment-1 peptides prevents chronic rejection by attenuating arteriosclerotic development and suppressing intragraft T cell and macrophage activation.Transplantation65: 854–859

    Article  PubMed  CAS  Google Scholar 

  55. Pattison JM, Nelson PJ, Huie P, Sibley RK, Krensky AM (1996) RANTES chemokine expression in transplant-associated accelerated atherosclerosis.J Heart Lung Transplant15: 1194–1199

    PubMed  CAS  Google Scholar 

  56. Russell ME, Adams DH, Wyner LR, Yamashita Y, Halnon NJ, Karnovsky MJ (1993) Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts.Proc Natl Acad Sci USA90: 6086–6090

    Article  PubMed  CAS  Google Scholar 

  57. Fairchild RL, VanBuskirk AM, Kondo T, Wakely ME, Orosz CG (1997) Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts.Transplantation63: 1807–1812

    Article  PubMed  CAS  Google Scholar 

  58. Russell ME, Wallace AF, Hancock WW, Sayegh MH, Adams DH, Sibinga NE, Wyner LR, Karnovsky MJ (1995) Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.Transplantation59: 572–578

    PubMed  CAS  Google Scholar 

  59. Geerling RA, Ansari AA, LaFond WA, Baumgartner WA, Wesselingh S, Herskowitz A (1998) Accelerated arteriosclerosis in aortic grafts: a role for cytokines in progressive intimai lesion development.Transplant Proc30: 946–947

    Article  PubMed  CAS  Google Scholar 

  60. Russell PS, Chase CM, Winn HJ, Colvin RB (1994) Coronary atherosclerosis in transplanted mouse hearts. III. Effects of recipient treatment with a monoclonal antibody to interferon-gamma.Transplantation57: 1367–1371

    Article  PubMed  CAS  Google Scholar 

  61. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN (1998) Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma.Am J Pathol152: 1187–1197

    PubMed  CAS  Google Scholar 

  62. Raisanen SA, Glysing JT, Koglin J, Russell ME (1998) Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipients.Am J Pathol152: 359–365

    Google Scholar 

  63. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P (1997) Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts.J Clin Invest100: 550–557

    Article  PubMed  CAS  Google Scholar 

  64. Shimokado K, Raines EW, Madtes DK, Barrett TB, Benditt EP, Ross R (1985) A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.Cell43: 277–286

    Article  PubMed  CAS  Google Scholar 

  65. Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growth factor.Cell46: 155–169

    Article  PubMed  CAS  Google Scholar 

  66. Saito S, Motomura N, Lou H, Ramwell PW, Foegh ML (1997) Specific effects of estrogen on growth factor and major histocompatibility complex class II antigen expression in rat aortic allograft.J Thorac Cardiovasc Surg114: 803–809

    Article  PubMed  CAS  Google Scholar 

  67. Lou H, Zhao Y, Delafontaine P, Kodama T, Katz N, Ramwell PW, Foegh ML (1997) Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels.Circulation96: 927–933

    Article  PubMed  CAS  Google Scholar 

  68. Lou H, Ramwell PW, Foegh ML (1998) Estradiol 17-beta represses insulin-like growth factor I receptor expression in smooth muscle cells from rabbit cardiac recipients.Transplantation66: 419–426

    Article  PubMed  CAS  Google Scholar 

  69. Zhao XM, Yeoh TK, Frist WH, Porterfield DL, Miller GG (1994) Induction of acidic fibroblast growth factor and full-length platelet-derived growth factor expression in human cardiac allografts. Analysis by PCRin situhybridization, and immunohistochemistry. Circulation90: 677–685

    Article  PubMed  CAS  Google Scholar 

  70. Shaddy RE, Hammond EH, Yowell RL (1996) Immunohistochemical analysis of platelet-derived growth factor and basic fibroblast growth factor in cardiac biopsy and autopsy specimens of heart transplant patients. AmJ Cardiol77: 1210–1215

    Article  PubMed  CAS  Google Scholar 

  71. Zhao XM, Citrin BS, Miller GG, Frist WH, Merrill WH, Fischell TA, Atkinson JB, Yeoh TK (1995) Association of acidic fibroblast growth factor and untreated low grade rejection with cardiac allograft vasculopathy.Transplantation59: 1005–1010

    Article  PubMed  CAS  Google Scholar 

  72. Alpers CE, Davis CL, Barr D, Marsh CL, Hudkins KL (1996) Identification of platelet-derived growth factor A and B chains in human renal vascular rejection.Am J Pathol148: 439–451

    PubMed  CAS  Google Scholar 

  73. Lemstrom KB, Koskinen PK (1997) Expression and localization of platelet-derived growth factor ligand and receptor protein during acute and chronic rejection of rat cardiac allografts.Circulation96: 1240–1249

    Article  PubMed  CAS  Google Scholar 

  74. Myllarniemi M, Calderon L, Lemstrom K, Buchdunger E, Hayry P (1997) Inhibition of platelet-derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation.FASEB J11: 1119–1126

    PubMed  CAS  Google Scholar 

  75. Sihvola R, Koskinen P, Myllarniemi M, Loubtchenkov M, Hayry P, Buchdunger E, Lemstrom K (1999) Prevention of cardiac allograft arteriosclerosis by protein tyrosine kinase inhibitor selective for platelet-derived growth factor receptor.Circulation99: 2295–2301

    Article  PubMed  CAS  Google Scholar 

  76. Koglin J, Glysing JT, Raisanen SA, Russell ME (1998) Immune sources of transforming growth factor-betal reduce transplant arteriosclerosis: insight derived from a knockout mouse model.Circ Res83: 652–660

    Article  PubMed  CAS  Google Scholar 

  77. Wagner CR, Morris TE, Shipley GD, Hosenpud JD (1993) Regulation of human aortic endothelial cell-derived mesenchymal growth factors by allogeneic lymphocytesin vitro.A potential mechanism for cardiac allograft vasculopathy.J Clin Invest92: 1269–1277

    Article  PubMed  CAS  Google Scholar 

  78. Hosenpud JD, Morris TE, Shipley GD, Mauck KA, Wagner CR (1996) Cardiac allograft vasculopathy. Preferential regulation of endothelial cell-derived mesenchymal growth factors in response to a donor-specific cell-mediated allogeneic response.Transplantation61: 939–948

    Article  PubMed  CAS  Google Scholar 

  79. Rose EA, Pepino P, Barr ML, Smith CR, Ratner AJ, Ho E, Berger C (1992) Relation of HLA antibodies and graft atherosclerosis in human cardiac allograft recipients.J Heart Lung Transplant11: S120–S123

    PubMed  CAS  Google Scholar 

  80. Smith JD, Danskine AJ, Rose ML, Yacoub MH (1992) Specificity of lymphocytotoxic antibodies formed after cardiac transplantation and correlation with rejection episodes.Transplantation53: 1358–1362

    Article  PubMed  CAS  Google Scholar 

  81. Hosenpud JD, Everett JP, Morris TE, Wagner CR, Shipley GD (1995) Cellular and humoral immunity to vascular endothelium and the development of cardiac allograft vasculopathy.J Heart Lung Transplant14: S185–S187

    PubMed  CAS  Google Scholar 

  82. Chow LH, Huh S, Jiang J, Zhong R, Pickering JG (1996) Intimal thickening develops without humoral immunity in a mouse aortic allograft model of chronic vascular rejection.Circulation94: 3079–3082

    Article  PubMed  CAS  Google Scholar 

  83. Russell PS, Chase CM, Winn HJ, Colvin RB (1994) Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity.J Immunol152: 5135–5141

    PubMed  CAS  Google Scholar 

  84. Harris PE, Bian H, Reed EF (1997) Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: a possible mechanism for transplant atherosclerosis.J Immunol159: 5697–5704

    PubMed  CAS  Google Scholar 

  85. Ravalli S, Albala A, Ming M, Szabolcs M, Barbone A, Michler RE, Cannon PJ (1998) Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease.Circulation97: 2338–2345

    Article  PubMed  CAS  Google Scholar 

  86. Lafond WA, Chen CL, Augustine S, Wu TC, Hruban RH, Lowenstein CJ (1997) Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis.Am J Pathol151: 919–925

    Google Scholar 

  87. Shears LL, Kawaharada N, Tzeng E, Billiar TR, Watkins SC, Kovesdi I, Lizonova A, Pham SM (1997) Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.J Clin Invest 100:2035–2042

    Article  PubMed  CAS  Google Scholar 

  88. Russell ME, Wallace AF, Wyner LR, Newell JB, Karnovsky MJ (1995) Upregulation and modulation of inducible nitric oxide synthase in rat cardiac allografts with chronic rejection and transplant arteriosclerosis.Circulation92: 457–464

    Article  PubMed  CAS  Google Scholar 

  89. Koglin J, Glysing JT, Mudgett JS, Russell ME (1998) Exacerbated transplant arteriosclerosis in inducible nitric oxide-deficient mice.Circulation97: 2059–2065

    Article  PubMed  CAS  Google Scholar 

  90. Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. JClin Invest83: 1774–1777

    Article  PubMed  CAS  Google Scholar 

  91. Lin H, Ignatescu M, Wilson JE, Roberts CR, Horley KJ, Winters GL, Costanzo MR, McManus BM (1996) Prominence of apolipoproteins B, (a), and E in the intimae of coronary arteries in transplanted human hearts: geographic relationship to vessel wall proteoglycans.J Heart Lung Transplant15: 1223–1232

    PubMed  CAS  Google Scholar 

  92. Shi C, Lee WS, Russell ME, Zhang D, Fletcher DL, Newell JB, Haber E (1997) Hypercholesterolemia exacerbates transplant arteriosclerosis via increased neointimal smooth muscle cell accumulation: studies in apolipoprotein E knockout mice.Circulation96: 2722–2728

    Article  CAS  Google Scholar 

  93. Raisanen SA, Tilly KM, Ustinov J, Mennander A, Paavonen T, Tikkanen MJ, Hayry P (1994) Hyperlipidemia accelerates allograft arteriosclerosis (chronic rejection) in the rat.Arterioscler Thromb14: 2032–2042

    Article  Google Scholar 

  94. Labarrere CA, Pitts D, Nelson DR, Faulk WP (1995) Vascular tissue plasminogen activator and the development of coronary artery disease in heart-transplant recipients.N Engl J Med333: 1111–1116

    Article  PubMed  CAS  Google Scholar 

  95. Faulk WP, Labarrere CA, Nelson DR, Pitts D (1995) Hemostasis, fibrinolysis, and natural anticoagulation in transplant vascular sclerosis.J Heart Lung Transplant14: S158–S164

    PubMed  CAS  Google Scholar 

  96. Moons L, Shi C, Ploplis V, Plow E, Haber E, Collen D, Carmeliet P (1998) Reduced transplant arteriosclerosis in plasminogen-deficient mice.J Clin Invest102: 1788–1797

    Article  PubMed  CAS  Google Scholar 

  97. Holschermann H, Bohle RM, Zeller H, Schmidt H, Stahl U, Fink L, Grimm H, Tillmanns H, Haberbosch W (1999) In situ detection of tissue factor within the coronary intima in rat cardiac allograft vasculopathy.Am J Pathol154: 211–220

    Article  PubMed  CAS  Google Scholar 

  98. Fang JC, Kinlay S, Kundsin R, Ganz P (1998) Chlamydia pneumoniae infection is frequent but not associated with coronary arteriosclerosis in cardiac transplant recipients.Am J Cardiol82: 1479–1483

    Article  PubMed  CAS  Google Scholar 

  99. Geist LJ, Dai LY (1996) Cytomegalovirus modulates interleukin-6 gene expression.Transplantation62: 653–658

    Article  PubMed  CAS  Google Scholar 

  100. Iwamoto GK, Konicek SA (1997) Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.J Investig Med45: 175–182

    PubMed  CAS  Google Scholar 

  101. Humbert M, Devergne O, Cerrina J, Rain B, Simonneau G, Dartevelle P, Duroux P, Galanaud P, Emilie D (1992) Activation of macrophages and cytotoxic cells during cytomegalovirus pneumonia complicating lung transplantations.Am Rev Respir Dis145: 1178–1184

    Article  PubMed  CAS  Google Scholar 

  102. Waldman WJ, Knight DA (1996) Cytokine-mediated induction of endothelial adhesion molecule and histocompatibility leukocyte antigen expression by cytomegalovirus-activated T cells.Am J Pathol148: 105–119

    PubMed  CAS  Google Scholar 

  103. Burns LJ, Pooley JC, Walsh DJ, Vercellotti GM, Weber ML, Kovacs A (1999) Intercellular adhesion molecule-1 expression in endothelial cells is activated by cytomegalovirus immediate early proteins.Transplantation67: 137–144

    Article  PubMed  CAS  Google Scholar 

  104. Streblow DN, Soderberg-Naucler C, Vieira J, Smith P, Wakabayashi E, Ruchti F, Mattison K, Altschuler Y, Nelson JA (1999) The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration.Cell99: 511–520

    Article  PubMed  CAS  Google Scholar 

  105. Koskinen P, Lemstrom K, Bruggeman C, Lautenschlager I, Hayry P (1994) Acute cytomegalovirus infection induces a subendothelial inflammation (endothelialitis) in the allograft vascular wall. A possible linkage with enhanced allograft arteriosclerosis.Am J Pathol144: 41–50

    PubMed  CAS  Google Scholar 

  106. Lemstrom KB, Bruning JH, Bruggeman CA, Lautenschlager IT, Hayry PJ (1994) Triple drug immunosuppression significantly reduces immune activation and allograft arteriosclerosis in cytomegalovirus-infected rat aortic allografts and induces early latency of viral infection. AmJ Pathol144: 1334–1347

    PubMed  CAS  Google Scholar 

  107. Lemstrom KB, Aho PT, Bruggeman CA, Hayry PJ (1994) Cytomegalovirus infection enhances mRNA expression of platelet-derived growth factor-BB and transforming growth factor-beta 1 in rat aortic allografts. Possible mechanism for cytomegalovirusenhanced graft arteriosclerosis.Arterioscler Thromb14: 2043–2052

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Box 100275, Gainesville, FL, 32610, USA

    Dani S. Zander

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  1. Dani S. Zander
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  1. Division of Cardiovascular Disease, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 532, Little Rock, AR, 72205-7199, USA

    Jay L. Mehta

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© 2001 Springer Basel AG

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Zander, D.S. (2001). Transplantation-associated arteriosclerosis and inflammation. In: Mehta, J.L. (eds) Inflammatory and Infectious Basis of Atherosclerosis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8239-2_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8239-2_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9487-6

  • Online ISBN: 978-3-0348-8239-2

  • eBook Packages: Springer Book Archive

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