Abstract
Vocal fold nodules are the most common organic laryngeal pathology seen in professional voice users and voice patients overall, identified in 15% of patients presenting with dysphonia. They are defined as bilateral phonotraumatic lesions that respond to voice therapy. This chapter reviews the evidence basis for the pathophysiology, diagnosis, and treatment of vocal fold nodules.
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References
Rosen CA, Gartner-Schmidt J, Hathaway B, et al. A nomenclature paradigm for benign midmembranous vocal fold lesions. Laryngoscope. 2012;122(6):1335–41.
Van Houtte E, Van Lierde K, D’Haeseleer E, Claeys S. The prevalence of laryngeal pathology in a treatment-seeking population with dysphonia. Laryngoscope. 2010;120(2):306–12.
Woo SH, Kim RB, Choi SH, Lee SW, Won SJ. Prevalence of laryngeal disease in South Korea: data from the Korea national health and nutrition examination survey from 2008 to 2011. Yonsei Med J. 2014;55(2):499–507.
Martins RHG, Defaveri J, Domingues MAC, et al. Vocal fold nodules: morphological and immunohistochemical investigations. J Voice. 2010;24:531–9.
Courey MS, Shohet JA, Scott MA, Ossoff RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol. 1996;105(7):525–31.
Grinnell F. Fibronectin and wound healing. J Cell Biochem. 1984;26(2):107–16.
Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol. 1995;104:13–8.
Jiang JJ, Titze IR. Measurement of vocal fold intraglottal pressure and impact stress. J Voice. 1994;8(2):132–44.
Poels PJ, de Jong FI, Schutte HK. Consistency of the preoperative and intraoperative diagnosis of benign vocal fold lesions. J Voice. 2003;17(3):425–33.
Mori MC, Francis DO, Song PC. Identifying occupations at risk for laryngeal disorders requiring specialty voice care. Otolaryngol Head Neck Surg. 2017;157(4):670–5.
Fritzell B. Voice disorders and occupation. Logoped Phoniatr Vocol. 2009;21(1):7–12.
Zhukhovitskaya A, Battaglia D, Khosla SM, Murry T, Sulica L. Gender and age in benign vocal fold lesions. Laryngoscope. 2015;125(1):191–6.
Yano J, Ichimura K, Hoshino T, Nozue M. Personality factors in pathogenesis of polyps and nodules of vocal cords. Auris Nasus Larynx. 1982;9(2):105–10.
Bouchayer M, Cornut G. Microsurgical treatment of benign vocal fold lesions: indications, technique, results. Folia Phoniatr (Basel). 1992;44(3–4):155–84.
Kuhn J, Toohill RJ, Ulualp SO, et al. Pharyngeal acid reflux events in patients with vocal cord nodules. Laryngoscope. 1998;108(8 Pt 1):1146–9.
Tasli H, Eser B, Asik MB, Birkent H. Does pepsin play a role in etiology of laryngeal nodules? J Voice. 2019;33:704–7.
Ylitalo R, Ramel S. Extraesophageal reflux in patients with contact granuloma: a prospective controlled study. Ann Otol Rhinol Laryngol. 2002;111:441–6.
McFarlane SC, Watterson TL. Vocal nodules: endoscopic study of their variations and treatment. Semin Speech Lang. 1990;11:47–59.
Salturk Z, Ozdemir E, Sari H, et al. Assessment of resonant voice therapy in the treatment of vocal fold nodules. J Voice. 2019;33:810.e1–4.
Murry T, Woodson GE. A comparison of three methods for the management of vocal fold nodules. J Voice. 1992;6(3):271–6.
Mansuri B, Tohidast SA, Soltaninejad N, Kamali M, Ghelichi L, Azimi H. Nonmedical treatments of vocal fold nodules: a systematic review. J Voice. 2018;32(5):609–20.
Holmberg EB, Hillman RE, Hammarberg B, Södersten M, Doyle P. Efficacy of a behaviorally based voice therapy protocol for vocal nodules. Voice. 2001;15(3):395–412.
Chernobelsky SI. The treatment and results of voice therapy amongst professional classical singers with vocal fold nodules. Logoped Phoniatr Vocol. 2007;32(4):178–84.
Fu S, Theodoros DG, Ward EC. Intensive versus traditional voice therapy for vocal nodules: perceptual, physiological, acoustic and aerodynamic changes. J Voice. 2015;29(2):260, 31–44.
Jo YS, Kim MY, So YK. Impact of remnant nodules on immediate and long-term outcomes of voice therapy for vocal fold nodules. J Voice. 2019;S0892-1997:30316–9. Web. 18 June. 2020.
Alegria R, Freitas SV, Manso MC. Is there an improvement on acoustic voice parameters in patients with bilateral vocal fold nodules after voice therapy? A meta-analysis. Eur Arch Otorhinolaryngol. 2020;277:2163–72. Web. 18 June. 2020.
Hosoya M, Kobayashi R, Ishii T, et al. Vocal hygiene education program reduces surgical interventions for benign vocal fold lesions: a randomized controlled trial. Laryngoscope. 2018;128(11):2593–9.
Rangarathnam B, McCullough GH, Pickett H, Zraick RI, Tulunay-Ugur O, McCullough KC. Telepractice versus in-person delivery of voice therapy for primary muscle tension dysphonia. Am J Speech Lang Pathol. 2015;24(3):386–99.
Fu S, Theodoros DG, Ward EC. Delivery of intensive voice therapy for vocal fold nodules via telepractice: a pilot feasibility and efficacy study. J Voice. 2015;29(6):696–706.
Pedersen M, McGlashan J. Surgical versus non-surgical interventions for vocal cord nodules. Cochrane Database Syst Rev. 2001;(2).
Béquignon E, Bach C, Fugain C, et al. Long-term results of surgical treatment of vocal fold nodules. Laryngoscope. 2013;123(8):1926–30.
Woo JH, Kim DY, Kim JW, Oh EA, Lee SW. Efficacy of percutaneous vocal fold injections for benign laryngeal lesions: prospective multicenter study. Acta Otolaryngol. 2011;131(12):1326–32.
Wang CT, Liao LJ, Lai MS, Cheng PW. Comparison of benign lesion regression following vocal fold steroid injection and vocal hygiene education. Laryngoscope. 2014;124(2):510–5.
Wang CT, Lai MS, Cheng PW. Long-term surveillance following intralesional steroid injection for benign vocal fold lesions. JAMA Otolaryngol Head Neck Surg. 2017;143(6):589–94.
Sluka KA, Walsh DM. Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness. Pain. 2003;4:109–21.
Palmer S, Cramp F, Propert K, Godfrey H. Transcutaneous electrical nerve stimulation and transcutaneous spinal electroanalgesia: a preliminary efficacy and mechanisms-based investigation. Physiotherapy. 2009;95:185–91.
Sherry JE, Oehrlein KM, Hegge KS, Morgan BJ. Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance. Phys Ther. 2001;81(6):1183–91.
Penkner K, Janda M, Lorenzoni MA. A comparison of the muscular relaxation effect of TENS and EMG-biofeedback in patients with bruxism. J Oral Rehabil. 2001;28:849–53.
Santos JK, Silvério KCA, Diniz Oliveira NFC, et al. Evaluation of electrostimulation effect in women with vocal nodules. J Voice. 2016;30:769.e1–7.
Silverio KCA, Brasolotto AG, Siqueira LTD, et al. Effect of application of transcutaneous electrical nerve stimulation and laryngeal manual therapy in dysphonic women: clinical trial. J Voice. 2015;29:200–8.
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McGarey, P.O., Simpson, C.B. (2021). Vocal Fold Nodules. In: Rosow, D.E., Ivey, C.M. (eds) Evidence-Based Laryngology. Springer, Cham. https://doi.org/10.1007/978-3-030-58494-8_1
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DOI: https://doi.org/10.1007/978-3-030-58494-8_1
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