Abstract
Gremlin is a member of the TGF-β superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin–VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.
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Acknowledgments
This work was supported by the Instituto de Salud Carlos III and Fondos FEDER European Union (PI17/00119, Red de Investigación Renal REDinREN; RD16/0009), Sociedad Española de Nefrología, Comunidad Autónoma de Madrid (B2017/BMD-3751 NOVELREN-CM). The IMPROVE-PD project (‘Identification and Management of Patients at Risk – Outcome and Vascular Events in Peritoneal Dialysis’) received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No 812699.
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Marquez-Exposito, L. et al. (2020). Molecular Regulation of Notch Signaling by Gremlin. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1227. Springer, Cham. https://doi.org/10.1007/978-3-030-36422-9_6
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