Skip to main content

Subarachnoid Hemorrhage-Related Epilepsy

  • Chapter
  • First Online:
Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 127))

Abstract

Epilepsy is a significant worldwide public health problem that leads to reduced quality of life and negative psychosocial consequences and significantly increases mortality rates in those who are affected. The development of epilepsy from subarachnoid hemorrhage (SAH) has an important negative impact on long-term survival, functional status, and cognitive recovery in patients following aneurysmal rupture. Anticonvulsant medication (AED) administration to prevent the development of epilepsy following SAH is controversial, and studies to date have not shown effectiveness of AED use as prophylaxis. This paper reviews the pathophysiology of SAH in the development of epilepsy, the scope of the problem of epilepsy related to SAH, and the studies that have evaluated AED administration as prophylaxis for seizures and epilepsy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Abdul-Muneer PM, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol. 2015;51:966–79.

    Article  CAS  Google Scholar 

  2. Baker GA. The psychosocial burden of epilepsy. Epilepsia. 2002;43(Suppl 6):26–30.

    Article  Google Scholar 

  3. Barker-Haliski ML, Löscher W, White HS, Galanopoulou AS. Neuroinflammation in epileptogenesis. Epilepsia. 2017;58(Suppl 3):39–47.

    Article  CAS  Google Scholar 

  4. Baumann RJ, Marx BM, Leonidakis MG. An estimate of the prevalence of epilepsy in a rural Appalachian population. Am J Epidemiol. 1977;106:42–52.

    Article  CAS  Google Scholar 

  5. Birbeck G, Chomba E, Atadzhanov M, Mbewe E, Haworth A. The social and economic impact of epilepsy in Zambia: a cross-sectional study. Lancet Neurol. 2007;6:39–44.

    Article  Google Scholar 

  6. De Marchis GM, Pugin D, Meyers E, Velasquez A, Suwatcharangkoon S, Park S, Falo MC, Agarwal S, Mayer S, Schmidt JM, Connolly ES, Claassen J. Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome. Neurology. 2016;86:253–60.

    Article  Google Scholar 

  7. Fletcher A, Sims-Williams H, Wabulya A, Boling W. Stigma and quality of life at long-term follow-up after surgery for epilepsy in Uganda. Epilepsy Behav. 2015;52:128–31.

    Article  Google Scholar 

  8. Helmstaedter C, Elger CE. Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease? Brain. 2009;132:2822–30.

    Article  CAS  Google Scholar 

  9. Hesdorffer DC, Beck V, Begley CE, Bishop ML, Cushner-Weinstein S, Holmes GL, Shafer PO, Sirven JI, Austin JK. Research implications of the Institute of Medicine Report, Epilepsy Across the Spectrum: Promoting Health and Understanding. Epilepsia. 2013;54:207–16.

    Article  Google Scholar 

  10. Human T, Diringer MN, Allen M, Zipfel GJ, Chicoine M, Dacey R, Dhar R. A randomized trial of brief versus extended seizure prophylaxis after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2018;28(2):169–74. https://doi.org/10.1007/s12028-017-0440-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Huttunen J, Kurki MI, von Und Zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen JE, Kälviäinen R, Immonen A. Epilepsy after aneurysmal subarachnoid hemorrhage: a population-based, long-term follow-up study. Neurology. 2015;84:2229–37.

    Article  Google Scholar 

  12. Huttunen J, Lindgren A, Kurki MI, Huttunen T, Frösen J, Koivisto T, von Und Zu Fraunberg M, Immonen A, Jääskeläinen JE, Kälviäinen R. Epilepsy-associated long-term mortality after aneurysmal subarachnoid hemorrhage. Neurology. 2017;89:263–8.

    Article  Google Scholar 

  13. Kaddumukasa M, Mugeny L, Kaddumukasa MN, Ddumba E, Devereaux M, Furlan A, Sajatovic M, Katabira E. Prevalence and incidence of neurological disorders among adult Ugandans in rural and urban Mukono district; a cross-sectional study. BMC Neurol. 2016;16:227.

    Article  Google Scholar 

  14. Korff CM, Dale RC. The immune system in pediatric seizures and epilepsies. Pediatrics. 2017. https://doi.org/10.1542/peds.2016-3534.

    Article  Google Scholar 

  15. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314–9.

    Article  CAS  Google Scholar 

  16. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshé SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51:1069–77.

    Article  CAS  Google Scholar 

  17. Marigold R, Günther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. 2013. http://www.cochrane.org/CD008710/EPILEPSY_antiepileptic-drugs-for-the-primary-and-secondary-prevention-of-seizures-after-subarachnoid-haemorrhage. Accessed 1 Mar 2018.

  18. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study. Lancet. 2012;380:2197–223.

    Article  Google Scholar 

  19. Naidech AM, Kreiter KT, Janjua N, Ostapkovich N, Parra A, Commichau C, Connolly ES, Mayer SA, Fitzsimmons BF. Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage. Stroke. 2005;36:583–7.

    Article  CAS  Google Scholar 

  20. Olafsson E, Gudmundsson G, Hauser WA. Risk of epilepsy in long-term survivors of surgery for aneurysmal subarachnoid hemorrhage: a population-based study in Iceland. Epilepsia. 2000;41:1201–5.

    Article  CAS  Google Scholar 

  21. Panczykowski D, Pease M, Zhao Y, Weiner G, Ares W, Crago E, Jankowitz B, Ducruet AF. Prophylactic antiepileptics and seizure incidence following subarachnoid hemorrhage: a propensity score-matched analysis. Stroke. 2016;47:1754–60.

    Article  CAS  Google Scholar 

  22. Raper DM, Starke RM, Komotar RJ, Allan R, Connolly ES Jr. Seizures after aneurysmal subarachnoid hemorrhage: a systematic review of outcomes. World Neurosurg. 2013;79:682–90.

    Article  Google Scholar 

  23. Regan RF, Panter SS. Neurotoxicity of hemoglobin in cortical cell culture. Neurosci Lett. 1993;153:219–22.

    Article  CAS  Google Scholar 

  24. Rush B, Wiskar K, Fruhstorfer C, Hertz P. Association between seizures and mortality in patients with aneurysmal subarachnoid hemorrhage: a nationwide retrospective cohort analysis. Seizure. 2016;41:66–9.

    Article  Google Scholar 

  25. Sadrzadeh SMH, Eaton JW. Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest. 1988;82:1510–5.

    Article  CAS  Google Scholar 

  26. Sperling MR, Feldman H, Kinman J, Liporace JD, O’Connor MJ. Seizure control and mortality in epilepsy. Ann Neurol. 1999;46:45–50.

    Article  CAS  Google Scholar 

  27. Ueda Y, Willmore LJ, Triggs WJ. Amygdalar injection of FeCl3 causes spontaneous recurrent seizures. Exp Neurol. 1998;153:123–7.

    Article  CAS  Google Scholar 

  28. van Vliet EA, Aronica E, Vezzani A, Ravizza T. Review: neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. Neuropathol Appl Neurobiol. 2018;44:91–111.

    Article  Google Scholar 

  29. Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neurol. 2011;7:31–40.

    Article  CAS  Google Scholar 

  30. Willmore LJ, Sypert GW, Munson JB, Hurd RW. Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex. Science. 1978;200:1501–3.

    Article  CAS  Google Scholar 

  31. Yip S, Sastry B. Effects of hemoglobin and its breakdown products on synaptic transmission in rat hippocampal CA1 neurons. Brain Res. 2000;864:1–12.

    Article  CAS  Google Scholar 

Download references

Conflict of Interest

The authors affirm that they have no conflicts of interest related to this manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Warren Boling .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Boling, W., Kore, L. (2020). Subarachnoid Hemorrhage-Related Epilepsy. In: Martin, R., Boling, W., Chen, G., Zhang, J. (eds) Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 127. Springer, Cham. https://doi.org/10.1007/978-3-030-04615-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-04615-6_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04614-9

  • Online ISBN: 978-3-030-04615-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics