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TGF-β/BMP Signaling in Pulmonary Vascular Disease

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Vascular Complications in Human Disease

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Abstract

The transforming growth factor β (TGF-β) superfamily is a group of multifunctional proteins with over 35 distinct members, including TGF-β, activins, bone morphogenetic proteins (BMPs), and growth differentiation factors.1 They all have profound effects on developmental processes ranging from soft tissue and skeletal development to vasculogenesis.2 The effects are not limited to embryogenesis alone as these molecules are also known to play significant roles in the maintenance and control of adult tissues.2–4 Although TGF-β is the prototypic member of the family, the largest group of cytokines within the TGF-β superfamily comprises the BMPs. They were originally identified as molecules regulating growth and differentiation of bone and cartilage. However, BMPs are now known to regulate growth, differentiation, and apoptosis in a diverse number of cells lines, including mesenchymal and epithelial cells.2–4

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Author information

Authors and Affiliations

  1. Department of Respiratory Medicine, University of Cambridge, Cambridgeshire, UK

    Rachel J. Davies MA, MRCP & Nicholas W. Morrell MA, MD, FRCP

Authors
  1. Rachel J. Davies MA, MRCP
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  2. Nicholas W. Morrell MA, MD, FRCP
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Editor information

Editors and Affiliations

  1. Royal Free and University College Medical School, London, UK

    David Abraham PhD (Professor of Cellular and Molecular Biology) (Professor of Cellular and Molecular Biology)

  2. Clinical Biochemistry, Royal Free and University College Hospital Medical School, London, UK

    Michael Dashwood PhD (Principal Research Fellow) (Principal Research Fellow)

  3. The National Pulmonary Hypertension Unit, Royal Free Hospital, London

    Clive Handler BSc, MD, MRCP, FACC, FESC (Consultant in Pulmonary Hypertension and Honorary Senior Lecturer) (Consultant in Pulmonary Hypertension and Honorary Senior Lecturer)

  4. Department of Medicine, Royal Free and University College Hospital Medical School, London, UK

    Clive Handler BSc, MD, MRCP, FACC, FESC (Consultant in Pulmonary Hypertension and Honorary Senior Lecturer) (Consultant in Pulmonary Hypertension and Honorary Senior Lecturer)

  5. Royal Free Hospital, London, UK

    Gerry Coghlan MD, FRCP (Consultant Cardiologist) (Consultant Cardiologist)

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Davies, R.J., Morrell, N.W. (2008). TGF-β/BMP Signaling in Pulmonary Vascular Disease. In: Abraham, D., Dashwood, M., Handler, C., Coghlan, G. (eds) Vascular Complications in Human Disease. Springer, London. https://doi.org/10.1007/978-1-84628-919-4_4

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