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Development of Central Autonomic Regulation of Cardiovascular Function

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Developmental Neurobiology of the Autonomic Nervous System

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Although investigators have been interested in autonomic regulation of cardiovascular function for well over 100 yr, regulation in the perinatal period has been investigated systematically for only the last 25 yr. Whereas considerable progress has been made concerning neural regulation of cardiovascular function in the adult, the amount of quantitative information concerning the perinatal period is quite limited (5,32,35,38,52). It is only recently that the neonatal cardiovascular regulatory system and its postnatal maturation, particularly with reference to asynchronous development of autonomic regulation, has begun to interest investigators and information is becoming available. In collaboration with a number of different investigators, I have been examining postnatal development of central neural regulation of cardiovascular function. This chapter will review the information that we have gathered over the past 18 yr, and attempt to place it in the framework of ongoing studies of postnatal autonomic regulation of cardiovascular function by other investigators.

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References

  1. Assali, N. S., C. P. Brinkman III, R. Woods, Jr., A. Dandavino, and B. Nuwayhid (1978) Ontogenesis of the autonomic control of cardiovascular functions in the sheep. in Fetal and Newborn Cardiovascular Physiology, Vol. 1, Developmental Aspects, Garland STPM Press, New York, pp. 47–91.

    Google Scholar 

  2. Benfordo, J. M., W. Flacke, C. R. Swaine and W. Mosimann (1960) Studies on veratrum alkaloids XXIX. The Action of some germine esters and of enratridine upon blood pressure, heart rate, and femoral blood flow in the dog. J. Pharmacol. Exptl. Therap. 130, 311–320.

    Google Scholar 

  3. Broadie, T. A., M. Davedas, J. Rysavy, J. P. Delaney, and A. S. Leonars (1973) The effect of hypoxia and posterior hypothalamic stimulation on colonic blood flow in the weanling puppy. J. Pediatri. Surg. 8, 747–756.

    Article  CAS  Google Scholar 

  4. Buckley, B. J., N. Gootman, J. S. Nagelberg, P. G. Griswold, and P. M. Gootman (1984) Cardiovascular responses to arterial and venous hemorrhage in neonatal swine. Am. J. Physiol. 247, R626–R633.

    Google Scholar 

  5. Buckley, N. M. (1983) Regional circulatory function in the perinatal period, in Perinatal Cardiovascular Function. (N. Gootman and P. M. Gootman, eds.) Marcel Dekker New York, pp. 227–264.

    Google Scholar 

  6. Buckley, N. M. (1984) Regulation of regional vascular beds by the developing autonomic nervous system, in Developmental Neurobiology of the Autonomic Nervous System, (P. M. Gootman, ed.) Humana Press, NJ, pp 00–00.

    Google Scholar 

  7. Buckley, N. M., P. Brazeau, and I. D. Frasier (1983) Circulatory effects of splanchnic nerve stimulation in developing swine. Fed. Proc. 42, 1115.

    Google Scholar 

  8. Buckley, N. M., P. Brazeau, I. D. Frasier, and P. M. Gootman (1981) Femoral circulatory responses to lumbar nerve stimulation in developing swine under pentobarbital anesthesia. Am. J. Physiol. 240, H505–H510. 9. Buckley, N. M., P. Brazeau, and P. M. Gootman (1983) Maturation of circulatory response to adrenergic stimuli. Fed. Proc. 42, 1645–1649.

    Google Scholar 

  9. Buckley, N. M., P. Brazeau, P. M. Gootman, and I. D. Frasier (1979) Renal circulatory effects of adrenergic stimuli in anesthetized piglets and mature swine. Am. J. Physiol. 237, H690–H695.

    Google Scholar 

  10. Buckley, N. M., P. M. Gootman, N. Gootman, G. D. Reddy, L. C. Weaver, and L. A. Crane (1976) Age-dependent cardiovascular effects of afferent stimulation in neonatal pigs. Biol. Neonate, 30, 268–279.

    Article  Google Scholar 

  11. Buckley, N. M., P. M. Gootman, E. L. Yellin, and P. Brazeau (1979) Age-related cardiovascular effects of catecholamines in anesthetized piglets. Circ. Res. 45, 282–292.

    Article  PubMed  CAS  Google Scholar 

  12. Cohen, M. I. (1979) Neurogenesis of respiratory rhythm in the mammal. Physiol. Rev. 59, 1105–1173.

    PubMed  CAS  Google Scholar 

  13. Cohen, M. I. and P. M. Gootman (1970) Periodicities in efferent discharge of splanchnic nerve of the cat. Am. J. Physiol. 218, 1092–1101.

    PubMed  CAS  Google Scholar 

  14. Cohen, M. I., P. M. Gootman, and J. L. Feldman (1980) Inhibition of sympathetic discharge by lung inflation, in Arterial Baroreceptors and Hypertension (P. Sleight, ed.) Oxford, pp. 161–167.

    Google Scholar 

  15. Crane, L., N. Gootman, and P. M. Gootman (1974) The effects of decamethonium (C-10) on blood pressure and heart rate in newborn piglets. Arch. Int. Pharmacodyn. Therap. 208, 52–60.

    CAS  Google Scholar 

  16. Crane, L., N. Gootman, and P. M. Gootman (1975) Agedependent cardiovascular effects of halothane anesthesia in neonatal pigs. Arch. Int. Pharmacodyn. Ther. 214, 180–187.

    PubMed  CAS  Google Scholar 

  17. Dawes, G. S. and J. H. Comroe, Jr. (1954) Chemoreflexes from the heart and lungs. Physiol. Rev. 34, 167–201.

    PubMed  CAS  Google Scholar 

  18. Dawes, G. S., B. M. Johnston, and D. W. Walker (1980) Relationship of arterial pressure and heart rate in fetal, newborn and adult sheep. J. Physiol. 309, 405–417.

    PubMed  CAS  Google Scholar 

  19. Dawes, G. S., J. C. Mott, and J. G. Widdicombe (1951) Respiratory and cardiovascular reflexes from the heart and lungs. J. Physiol. 115, 258–291.

    PubMed  CAS  Google Scholar 

  20. Downing, S. E. (1960) Baroreceptor reflexes in newborn rabbits. J. Physiol. 150, 201–213.

    PubMed  CAS  Google Scholar 

  21. Earley, A. Ng. S. Fayers, E. A. Shinebourne, and M. de. Swiet (1980) Blood pressure in the first 6 weeks of life. Arch Dis. Child. 55, 755–757.

    Article  PubMed  CAS  Google Scholar 

  22. Frantz, I. D. III, P. L’Heureux, R. R. Engel, and C. E. Hunt (1975) Nectrotizing enterocolitis. J. Pediatr. 86, 259–263.

    Article  PubMed  Google Scholar 

  23. Gelhorn, E. (1939) Effect of hemorrhage, reinjection of blood and dextran on the activity of the sympathetic and parasympathetic systems. Acta Neuroveg. 22, 291–299.

    Article  Google Scholar 

  24. Goldman, H. I. (1980) Feeding and necrotizing enterocolitis. Am J. Dis. Child. 134, 553–555.

    PubMed  CAS  Google Scholar 

  25. Gootman, N., B. J. Buckley, P. M. Gootman, P. G. Griswold, J. D. Mele, and D. B. Nudel (1983) Maturation-related differences in regional circulatory effects of dopamine infusion in swine. Dev. Pharmacol. Ther. 6, 6–22.

    Google Scholar 

  26. Gootman, N., B. J. Buckley, P. M. Gootman, and J. S. Nagelberg (1982) Age-related effects of single injections of dopamine on cardiovascular function in developing swine. Dev. Pharmacol. Ther. 4, 139–150.

    PubMed  CAS  Google Scholar 

  27. Gootman, N., P. M. Gootman, B. J. Buckley, P. G. Griswold, and B. J. Peterson (1982) Age-related alterations in circulatory function during hypoxia. Pediatr. Res. 16, 100A.

    Google Scholar 

  28. Gootman, N., P. M. Gootman, B. J. Buckley, P. G. Griswold, and M. Sugarman (1981) Postnatal maturation of autonomic responses of the superior mesenteric artery. Fed. Proc. 40, 559.

    Google Scholar 

  29. Gootman, N., P. M. Gootman, N. M. Buckley, M. I. Cohen, M. I. Levine, and R. Spielberg (1972) Central vasomotor regulation in the newborn piglet (Sus scrofa). Am. J. Physiol. 222, 994–999.

    PubMed  CAS  Google Scholar 

  30. Gootman, N., P. M. Gootman, L. A. Crane, and B. J. Buckley (1979) Integrated cardiovascular responses to combined somatic and visceral afferent stimulation in newborn piglets. Biol. Neonate, 36, 70–77.

    Article  PubMed  CAS  Google Scholar 

  31. Gootman, P. M. (1983) Postnatal development of central nervous system regulation of cardiovascular function, in Perinatal Cardiovascular Function (N. Gootman and P. M. Gootman, eds.) Dekker, NY, pp. 265–328.

    Google Scholar 

  32. Gootman, P. M., B. J. Buckley, N. Gootman, and P. G. Griswold (1979) Effects of hemorrhage on cardiovascular responses to medullary pressor area stimulation in neonatal pigs. Fed. Proc. 138, 1385.

    Google Scholar 

  33. Gootman, P. M., B. J. Buckley, N. Gootman, and M. E. SalinasZeballos (1985) Localization of vasoactive sites in the thalamus of newborn swine, in Physiological Development of Fetus and Newborn (C. T. Jones and P. W. Nathanielsz, ed.) Academic Press, NY, pp. 599–604.

    Google Scholar 

  34. Gootman, P. M., N. M. Buckley, and N. Gootman (1978) Postnatal maturation of the central neural cardiovascular regulatory system, in Fetal and Newborn Cardiovascular Physiology, Vol. 1, Developmental Aspects (L. D. Longo and D. D. Reneau, eds.) Garland STPM Press, New York, pp. 93–152.

    Google Scholar 

  35. Gootman, P. M., N. M. Buckley, and N. Gootman (1979) Postnatal development of neural control of the circulation, in Reviews in Perinatal Medicine, Vol. 3 (E. M. Scarpelli and E. V. Cosmi, eds.), Raven Press, New York, pp. 1–72.

    Google Scholar 

  36. Gootman, P. M., N. M. Buckley, N. Gootman, L. A. Crane, and B. J. Buckley (1978) Integrated cardiovascular responses to combined somatic afferent stimulation in newborn piglets. Biol. Neonate 34, 187–198.

    Article  PubMed  CAS  Google Scholar 

  37. Gootman, P. M., H. L. Cohen, S. M. DiRusso, A. P. Rudell, and L. Eberle (1982) Efferent splanchnic activity in neonatal swine. Neurosci. Abst 8, 6.

    Google Scholar 

  38. Gootman, P. M., H. L. Cohen, S. M. DiRusso, A. P. Rudell, and L. P. Eberle (1984) Characteristics of spontaneous efferent splanchnic discharge in developing swine, in Catecholamines Part A: Basic and Peripheral Mechanisms (E. Usdin, A. Dahlstrom, and A. Carlsson, eds.) Liss, New York, pp. 369–374.

    Google Scholar 

  39. Gootman, P. M., H. L. Cohen, and N. Gootman (1986) Autonomic control of heart rate in the perinatal period, in New Directions in Pediatric Electrocardiography (J. Liebman, R. Plansey, Y. Rudy, M. Nijhoff, eds.) The Hague.

    Google Scholar 

  40. Gootman, P. M. and M. I. Cohen (1970) Efferent splanchnic activity and systemic arterial pressure. Am. J. Physiol. 219, 897–903.

    PubMed  CAS  Google Scholar 

  41. Gootman, P. M. and M. I. Cohen (1971) Evoked potentials produced by electrical stimulation of medullary vasomotor regions. Exptl. Brain Res. 13, 1–14.

    Article  Google Scholar 

  42. Gootman, P. M. and M. I. Cohen (1973) Periodic modulation (cardiac and respiratory) of spontaneous and evoked sympathetic discharge. “Symposium on Central and Peripheral Adrenergic Mechanisms,” Warsaw, 1971 Acta Physiol. Polon. 24, 99–109.

    Google Scholar 

  43. Gootman, P. M. and M. I. Cohen (1974) The interrelationships between sympathetic discharge and central respiratory drive, in Central-Rhythmic and Regulation (Hippokrates-Verlag, S., W. Umbach, and H. P. Koepchen, eds.) pp. 195–209.

    Google Scholar 

  44. Gootman, P. M. and M. I. Cohen (1980) Origin of rhythms common to sympathetic outflows at different spinal levels, in Arterial Baroreceptors and Hypertension (P. Sleight, ed.) Oxford, pp. 154–160.

    Google Scholar 

  45. Gootman, P. M. and M. I. Cohen (1981) Sympathetic rhythms in spinal cats. J. Autonomic Nerv. System 3, 379–387.

    Article  CAS  Google Scholar 

  46. Gootman, P. M. and M. I. Cohen (1983) Inhibitory effects on fast sympathetic rhythms. Brain Res. 270, 134–136.

    Article  PubMed  CAS  Google Scholar 

  47. Gootman, P. M., M. I. Cohen, M. P. Piercey, and P. Wolotsky (1975) A search for medullary neurons with activity patterns similar to those in sympathetic nerves. Brain Res. 87, 395–406.

    Article  PubMed  CAS  Google Scholar 

  48. Gootman, P. M., S. M. DiRusso, B. J. Buckley, N. Gootman, A. C. Yao, P. E. Pierce, P. G. Griswold, M. P. Epstein, and H. L. Cohen. Age-related responses to stimulation of cardiopulmonary receptors in swine. Submitted to Am. J. Physiol.

    Google Scholar 

  49. Gootman, P. M., J. L. Feldman, and M. I. Cohen (1980) Pulmonary afferent influences on respiration modulation of sympathetic discharge, in Central Interactions Between Respiratory and Cardiovascular Control System (H. P. Koepchen, S. M. Hilton, and A. Trzebski, eds.) Springer-Verlag, New York, pp. 172–179.

    Chapter  Google Scholar 

  50. Gootman, P. M., N. Gootman, and B. J. Buckley (1983) Maturation of central autonomic control of the circulation. Fed. Proc. 42, 1648–1655.

    PubMed  CAS  Google Scholar 

  51. Gootman, P. M., N. Gootman, B. J. Buckley, P. G. Griswold, and B. J. Peterson (1982) Effects of hypoxia on cardiovascular responses to medullary pressor area stimulation in neonatal piglets. Fed. Proc. 41, 1520.

    Google Scholar 

  52. Gootman, P. M., N. Gootman, B. J. Buckley, and M. -E. SalinasZeballos (1983) Cardiovascular responses to stimulation of vasoactive thalamic sites in neonatal swine. Fed. Proc. 42, 1120.

    Google Scholar 

  53. Gootman, P. M., N. Gootman, P. D. M. V. Turlapaty, A. C. Yao, B. J. Buckley, and B. M. Altura (1981) Autonomic regulation of cardiovascular function in neonates, in Development of the Autonomic Nervous System Ciba Foundation Symposium 83. (G. Burnstock, ed.) London, Pitman Medical, pp. 70–93.

    Google Scholar 

  54. Gootman, P. M., A. C. Yao, S. M. DiRusso, P. E. Pierce, B. J. Buckley, and N. Gootman (1981) Age-related responses to stimulation of cardiopulmonary receptors in swine. Fed. Proc. 40, 523.

    Google Scholar 

  55. Granger, D. N., P. D. I. Richardson, P. R. Kvietys, and N. A. Mortillaro (1980) Intestinal blood flow. Gastroenterology 78, 837–863.

    PubMed  CAS  Google Scholar 

  56. Herbst, J. J., S. D. Minton, and I. S. Book (1979) Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. Pediatrics 95, 763–768.

    Article  CAS  Google Scholar 

  57. Hopkins, D. A. and J. A. Armour (1982) Medullary cells of origin of physiologically identified cardiac nerves in the dog. Brain Res. Bull. 8, 359–365.

    Article  PubMed  CAS  Google Scholar 

  58. Hopkins, D. A., P. M. Gootman, N. Gootman, S. M. DiRusso, and M. -E. Zeballos (1981) Localization of vagal cardiomotor neurons in neonatal pig. Neurosci. Abstr. 7, 115.

    Google Scholar 

  59. Hopkins, D. A., P. M. Gootman, N. Gootman, S. M. DiRusso, and M. -E. Zeballos (1984) Brainstem cells of origin of the cervical vagus and cardiac nerves in the neonatal pig (Sus scrofa). Brain Res. 306, 63–72.

    Article  PubMed  CAS  Google Scholar 

  60. Itskovitz, J., E. F. LaGamma, and A. M. Rudolph (1983) Baroreflex control of the circulation in chronically instrumented fetal lambs. Circ. Res. 52, 589–596.

    Article  PubMed  CAS  Google Scholar 

  61. Kalia, M. (1976) Visceral and somatic reflexes produced by J pulmonary receptors in newborn kittens. J. Appl. Physiol. 41, 1–6.

    CAS  Google Scholar 

  62. Kenigsberg, K., P. G. Griswold, B. J. Buckley, N. Gootman, and P. M. Gootman (1983) Cardiac effects of esophageal stimulation: Possible relationship between gastroesophageal reflux (GER) and sudden infant death syndrome (SIDS). J. Pediatr. Surg. 18, 542–545.

    Article  PubMed  CAS  Google Scholar 

  63. Kitterman, J. A, R. H. Phibbs, and W. H. Tooley (1969) Aortic blood pressure in normal newborn infants during the first 12 hours of life. Pediatrics 44, 959–968.

    PubMed  CAS  Google Scholar 

  64. Krayer, O. (1961) The history of the Bezold-Jarisch effect. Arch. Exp. Path. O. Pharmak. 240, 361–368.

    CAS  Google Scholar 

  65. Leape, I. L., T. M. Holder, J. D. Franklin, R. A. Armory, and K. W. Ashcraft (1977) Respiratory arrest in infants secondary to gastroesophageal reflux. Pediatrics 60, 924–927.

    PubMed  CAS  Google Scholar 

  66. Lees, B. J. and L. A. Cabal (1981) Increased blood pressure following pupillary dilation with 2.5% phenylephrine hydrochloride in preterm infants. Pediatrics 68, 231–234.

    PubMed  CAS  Google Scholar 

  67. LeGal, Y. M. (1983) Effect of acute hemorrhage on some physiological parameters of the cardiovascular system in newborn pigs. Biol. Neonate. 44, 210–218.

    Article  PubMed  CAS  Google Scholar 

  68. Mesulam, M. -M. (1978) Tetramethylbenzidine for horseradish peroxidase neurohistochemistry: A noncarcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J. Histochem. Cytochem. 26, 106–117.

    Article  PubMed  CAS  Google Scholar 

  69. Mills, E. and P. G. Smith (1983) Functional development of the cervical sympathetic pathway in the neonatal rat. Fed. Proc. 42, 1639–1642.

    PubMed  CAS  Google Scholar 

  70. Modanlou, H., S. -Y. Yeh, B. Siassi, and E. H. Hon (1974) Direct monitoring of arterial blood pressure in depressed normal infants during the first hour of life. J. Pediatrics 85, 553–559.

    Google Scholar 

  71. Paintal, A. S. (1973) Sensory mechanisms involved in the Bezold-Jarisch effect. Aust. J. Biol. Med. Sci. 51, 3–15.

    Article  CAS  Google Scholar 

  72. Reddy, G. D., N. Gootman, N. M. Buckley, P. M. Gootman, and L. Crane (1974) Regional blood flow changes in neonatal pigs in response to hypercapnia, hemorrhage, and sciatic nerve stimulation. Biol. Neonate. 25, 249–262.

    Article  PubMed  CAS  Google Scholar 

  73. Schleman, M., N. Gootman, and P. M. Gootman (1979) Cardiovascular and respiratory responses to right atrial injections of phenyl diguanide in pentobarbital-anesthetized newborn piglets. Pediatr. Res. 13, 1271–1274.

    Article  PubMed  CAS  Google Scholar 

  74. Smyth, H. S., P. Sleight, and G. W. Pickering (1969) Reflex regulation of arterial pressure during sleep in man. Circ. Res. 24, 109–121.

    Article  PubMed  CAS  Google Scholar 

  75. Swiet, M. de, R. Fancourt, and J. Peto (1975) Systolic blood pressure variation during the first 6 days of life. Clin. Sci. Mol. Med. 49, 557–561.

    PubMed  Google Scholar 

  76. Talbot, R. B. and M. J. Swenson (1970) Blood volume of pigs from birth through 6 weeks of age. Am. J. Physiol. 218, 1141–1144.

    PubMed  CAS  Google Scholar 

  77. Thoren, P. (1979) Role of cardiac vagal C-fibers in cardiovascular control. Rev. Physiol. Biochem. Pharmacol. 86, 1–94.

    Article  PubMed  CAS  Google Scholar 

  78. Tomomatsu, E. and K. Nishi (1982) Comparison of carotid sinus baroreceptor sensitivity in newborn and adult rabbits. Am. J. Physiol. 243, H546–H550.

    Google Scholar 

  79. Toulowkian, R. J., J. N. Posch, and R. Spencer (1972) The pathogenesis of ischemic gastroenterocolitis of the neonate: selective gut mucosal ischemia in asphyxiated neonatal piglets. J. Pediatr. Surg. 7, 194–205.

    Google Scholar 

  80. Turlapaty, P. D. M. V., B. T. Altura, and B. M. Altura (1978) Influence of TRIS on contractile responses of isolated rat aorta and portal vein. Am. J. Physiol. 235, H208–H213.

    Google Scholar 

  81. Turlapaty, P., B. T. Altura, P. M. Gootman, and B. M. Altura (1979) Vascular reactivity in blood vessels of neonatal pigs. Fed. Proc. 38, 437.

    Google Scholar 

  82. Turlapaty, P. D. M. V., B. T. Altura, P. M. Gootman, and B. M. Altura (1980) Do neonatal mammalian arteries and veins exhibit receptors for specific vasodilator hormones? Blood Vessels 17, 165–166.

    Google Scholar 

  83. Versmold, H. T., J. A. Kitterman, R. H. Phibbs, G. A. Gregory, and W. H. Tooley (1981) Aortic blood pressure during the first 12 hours of life in infants with birth weight 610–4220 grams. Pediatrics 67, 607–613.

    Google Scholar 

  84. Yao, A. C., P. M. Gootman, N. Gootman, P. E. Pierce, and S. M. DiRusso (1982) Effect of induced hypovolemia (HV) on superior mesenteric artery blood flow (MBF) response to feeding in piglets. Pediatr. Res. 16, 119A.

    Google Scholar 

  85. Yao, A. C., P. M. Gootman P. E. Pierce, and S. M. DiRusso (1984) Regional circulatory responses in 2–4 weeks old piglets. Effects of feeding and hemorrhage (H). Pediatric Res. 18, 218A.

    Article  Google Scholar 

  86. Yao, A. C., P. M. Gootman, P. E. Pierce, and S. M. DiRusso. Effects of Feeding on Regional Circulations of Developing Swine, in Swing in Biochemical Research (M. E. Tumbleson, ed.), Plenum, New York, in press.

    Google Scholar 

  87. Yao, A. C., P. M. Gootman, P. E. Pierce, S. M. DiRusso, and N. Gootman (1981) Feeding and superior mesenteric artery flow in newborn piglets. Pediatr. Res. 15, 688.

    Article  Google Scholar 

  88. Yao, A. C., P. M. Gootman, P. E. Pierce, and S. M. DiRusso (1985) Effects of feeding and hemorrhage on the femoral circulation of developing swine, in Physiological Development of Fetus and Newborn (C. T. Jones, and P. W. Nathanielsz, ed.) Academic Press, NY, pp. 445 449.

    Google Scholar 

  89. Yardley, R. W., G. Bowes, M. Wilkinson, J. P. Cannata, J. E. Maloney, B. C. Ritchie, and A. M. Walker (1983) Increased arterial pressure variability after arterial baroreceptor denervation in fetal lambs. Circ. Res. 52, 580–588.

    Article  PubMed  CAS  Google Scholar 

  90. Yoshikawa, T. (1968) Chapter V. The Brain of the Pig (Yorkshire Breed). Atlas of the Brains of Domestic Animals, University of Tokyo Press, Tokyo and Pennsylvania State University Press, University Park, PA, plates P1—P33.

    Google Scholar 

  91. Salinas-Zeballos, M.-E., G. A. Zeballos, and P. M. Gootman (1986). A Stereotaxic Atlas of Developing Swing (Sus serofa) Forebrain, in Swine in Biomedical Research (M. E. Tumbleson, ed.) Plenum, New York, in press.

    Google Scholar 

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  1. Department of Physiology, Downstate Medical Center, Brooklyn, New York, USA

    Phyllis M. Gootman

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Gootman, P.M. (1986). Development of Central Autonomic Regulation of Cardiovascular Function. In: Gootman, P.M. (eds) Developmental Neurobiology of the Autonomic Nervous System. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-459-7_11

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  • DOI: https://doi.org/10.1007/978-1-59259-459-7_11

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