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Embryonal Carcinoma Cells

The Malignant Counterparts of ES and EG Cells

  • Chapter
Human Embryonic Stem Cells

Abstract

Teratomas are histologically complex tumors containing a wide variety of distinct tissues, often in disorganized patterns, but sometimes with more or less recognizable tissue architecture and, occasionally, with recognizable organs. Teeth and hair are especially well known in dermoid cysts, the benign teratomas of the ovary. These tumors have excited interest and imagination throughout history, with their occasional obvious resemblance to abnormal embryos—hence the name, teratoma, from the Greek term for “monster.” In earlier times, different societies took them as mystical signs, sometimes as bad omens, sometimes to predict good fortune (e.g., see ref. 1). However, by the late 19th and early 20th centuries, pathologists began to develop more rational concepts of the causes and origins of teratomas, better rooted in the developing understanding of embryogenesis. Fascinating accounts of the natural history of these tumors and the development of ideas about their origins are provided by Damjanov and Solter (2) and Wheeler (3). The study of teratomas in the laboratory mouse and the identification of embryonal carcinoma (EC) cells as the pluripotent stem cells of teratocarcinomas provided a starting point that eventually led to the development of embryonic stem (ES) cell lines as tools for developmental biology and the recognition of their potential use in regenerative medicine.

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  1. Jonathan S. Draper
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  2. Harry Moore
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  3. Peter W. Andrews
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Editors and Affiliations

  1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

    Arlene Y. Chiu

  2. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Mahendra S. Rao

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Draper, J.S., Moore, H., Andrews, P.W. (2003). Embryonal Carcinoma Cells. In: Chiu, A.Y., Rao, M.S. (eds) Human Embryonic Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-423-8_4

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  • DOI: https://doi.org/10.1007/978-1-59259-423-8_4

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