Skip to main content
SpringerLink
Log in

Benign Fibrous, Fibrohistiocytic, and Myofibroblastic Lesions

  • Chapter
  • First Online:
Soft Tissue Tumors of the Skin

Abstract

This chapter covers a large number of benign entities grouped together for convenience under the broad categories of fibrous, fibrohistiocytic, and myofibroblastic lesions. Fibrous lesions generally demonstrate a conspicuous increase in collagen production and varying numbers of fibroblastic spindle cells. “Fibrohistiocytic,” a somewhat enigmatic term, is a general descriptor for tumors containing a combination of spindle cells of putative fibroblastic, myofibroblastic, and/or primitive mesenchymal cell origin and histiocytes (bone marrow-derived tissue macrophages and dendritic cells). Myofibroblastic lesions are composed of spindle cells with combined features of smooth muscle cells and fibroblasts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected References

  1. Aceñero MJ, Vorwald PW, Yamauchi SC. Calcifying fibrous pseudotumor affecting the retroperitoneum: could it be a new entity within the spectrum of IgG-4 sclerosing disease? Virchows Arch. 2010;456(6):719–21.

    PubMed  Google Scholar 

  2. Agaimy A, Michal M, Giedl J, Hadravsky L, Michal M. Superficial acral fibromyxoma: clinicopathological, immunohistochemical, and molecular study of 11 cases highlighting frequent Rb1 loss/deletions. Hum Pathol. 2017;60:192–8. PMID:27825811.

    CAS  PubMed  Google Scholar 

  3. Agaram NP, Zhang L, Sung YS, Chen CL, Chung CT, Antonescu CR, Fletcher CD. Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors. Am J Surg Pathol. 2016;40(10):1407–16.

    PubMed  PubMed Central  Google Scholar 

  4. Al-Ibraheemi A, Martinez A, Weiss SW, Kozakewich HP, Perez-Atayde AR, Tran H, Parham DM, Sukov WR, Fritchie KJ, Folpe AL. Fibrous hamartoma of infancy: a clinicopathologic study of 145 cases, including 2 with sarcomatous features. Mod Pathol. 2017;30(4):474–85.

    PubMed  Google Scholar 

  5. Allen PW. Nodular fasciitis. Pathology. 1972;4(1):9–26.

    CAS  PubMed  Google Scholar 

  6. Allen PW, Dymock RB, MacCormac LB. Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients. Am J Surg Pathol. 1988;12(7):519–30.

    CAS  PubMed  Google Scholar 

  7. Al-Zaid T, Wang WL, Lopez-Terrada D, Lev D, Hornick JL, Hafeez-Diwan A, Fletcher CD, Lazar AJ. Pleomorphic fibroma and dermal atypical lipomatous tumor: Are they related? J Cutan Pathol. 2013;40(4):378–84.

    Google Scholar 

  8. Amaravati R. Rare malignant transformation of a calcifying aponeurotic fibroma. J Bone Joint Surg Am. 2002;84-A(10):1889, author reply 1889.

    PubMed  Google Scholar 

  9. Balachandran K, Allen PW, MacCormac LB. Nuchal fibroma. A clinicopathological study of nine cases. Am J Surg Pathol. 1995;19(3):313–7. PMID:7872429.

    CAS  PubMed  Google Scholar 

  10. Bansal C, Stewart D, Li A, et al. Histologic variants of fibrous papule. J Cutan Pathol. 2005;32:424–8. 15953376.

    PubMed  Google Scholar 

  11. Barnhill RL, Mihm MC Jr. Cellular neurothekeoma. A distinctive variant of neurothekeoma mimicking nevomelanocytic tumors. Am J Surg Pathol. 1990;14:113–20.

    CAS  PubMed  Google Scholar 

  12. Beerman H. Lipid diseases as manifested in the skin. Med Clin N Am. 1951;35(2):433–56.

    CAS  PubMed  Google Scholar 

  13. Bertoni F, Unni KK, Beabout JW, et al. Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). Am J Surg Pathol. 1997;21(2):153–63.

    CAS  PubMed  Google Scholar 

  14. Boland JM, Folpe AL, Hornick JL, et al. Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. Am J Surg Pathol. 2009;33(8):1225–9.

    PubMed  Google Scholar 

  15. Brazzelli V, Rivetti N, Carugno A, Barruscotti S, Croci GA, Perani G, Borroni G. Eruptive xanthomas after extensive tattooing: a case report and literature review. G Ital Dermatol Venereol. 2015;150(6):770–1.Wilkes LL. Tendon xanthoma in type IV hyperlipoproteinemia. South Med J [Case Reports]. 1977;70(2):254–5.

    Google Scholar 

  16. Briganti A, Salonia A, Deho F, Zanni G, Rokkas K, Rigatti P, et al. Peyronie’s disease: a review. Curr Opin Urol. 2003;13(5):417–22.

    PubMed  Google Scholar 

  17. Bürgi J, Kunz B, Abrami L, Deuquet J, Piersigilli A, Scholl-Bürgi S, Lausch E, Unger S, Superti-Furga A, Bonaldo P, et al. CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome. Nat Commun. 2017;8:15861. https://doi.org/10.1038/ncomms15861.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Busam KJ, Mentzel T, Colpaert C, Barnhill RL, Fletcher CD. Atypical or worrisome features in cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol. 1998;22:1067–72.

    CAS  PubMed  Google Scholar 

  19. Calonje E, Mentzel T, Fletcher CD, Path MRC. Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence. Am J Surg Pathol. 1994;18(7):668–76.

    CAS  PubMed  Google Scholar 

  20. Calonje E, Guerin D, McCormick D, Fletcher CD. Superficial angiomyxoma: clinicopathologic analysis of a series of distinctive but poorly recognized cutaneous tumors with tendency for recurrence. Am J Surg Pathol. 1999;23(8):910–7.

    CAS  PubMed  Google Scholar 

  21. Carter JM, Wang X, Dong J, Westendorf J, Choux MM, Oliveira AM. USP6 genetic arrangements in cellular fibroma of tendon sheath. Mod Pathol. 2016;29(8):865–9.

    CAS  PubMed  Google Scholar 

  22. Cassier PA, Gelderblom H, Stacchiotti S, Thomas D, Maki RG, Kroep JR, van der Graaf WT, Italiano A, Seddon B, Dômont J, Bompas E, Wagner AJ, Blay JY. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. Cancer. 2012;118(6):1649–55.

    CAS  PubMed  Google Scholar 

  23. Chaudhry IH, Kazakov DV, Michal M, Mentzel T, Luzar B, Calonje E. Fibro-osseous pseudotumor of the digit: a clinicopathological study of 17 cases. J Cutan Pathol. 2010;37(3):323–9.

    PubMed  Google Scholar 

  24. Chung EB, Enzinger FM. Proliferative fasciitis. Cancer. 1975;36(4):1450–8.

    CAS  PubMed  Google Scholar 

  25. Chung EB, Enzinger FM. Fibroma of tendon sheath. Cancer. 1979;44(5):1945–54.

    CAS  PubMed  Google Scholar 

  26. Coffin CM, Hornick JL, Zhou H, Fletcher CDM. Gardner fibroma: A clinical, pathologic, and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol. 2007;31(3):410–6.

    PubMed  Google Scholar 

  27. Cohen BA, Hood A. Xanthogranuloma: report on clinical and histologic findings in 64 patients. Pediatr Dermatol. 1989;6(4):262–6.

    CAS  PubMed  Google Scholar 

  28. Cullen D, Díaz Recuero JL, Cullen R, Rodríguez Peralto JL, Kutzner H, Requena L. Superficial acral fibromyxoma: report of 13 cases with new immunohistochemical findings. Am J Dermatopathol. 2017;39(1):14–22. PMID:28045748.

    PubMed  Google Scholar 

  29. Darling TN, Skarulis MC, Steinberg SM, et al. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol. 1997;133:853–7.

    CAS  PubMed  Google Scholar 

  30. de Feraudy S, Fletcher CDM. Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases. Am J Surg Pathol. 2010;34(9):1377–81.

    PubMed  Google Scholar 

  31. de Feraudy S, Fletcher CD. Fibroblastic connective tissue nevus: a rare cutaneous lesion analyzed in a series of 25 cases. Am J Surg Pathol. 2012;36:1509.

    PubMed  Google Scholar 

  32. de Silva MV, Reid R. Myositis ossificans and fibroosseous pseudotumor of digits: a clinicopathologic review of 64 cases with emphasis on diagnostic pitfalls. Int J Surg Pathol. 2003;11:187–95.

    PubMed  Google Scholar 

  33. De Wever I, Dal Cin P, Fletcher CD, Mandahl N, Mertens F, Mitelman F, et al. Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group. Chromosomes and Morphology. Mod Pathol. 2000;13(10):1080–5. PMID:11048801.

    CAS  PubMed  Google Scholar 

  34. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. 2003;27(5):579–93.

    PubMed  Google Scholar 

  35. Denadai R, Bertola DR, Stelini RF, et al. Additional thoughts about juvenile hyaline fibromatosis and infantile systemic hyalinosis. Adv Anat Pathol. 2012;19(3):191–2; author reply 192.

    PubMed  Google Scholar 

  36. Downey C, Requena L, Bagué S, Sánchez Martínez MÁ, Lloreta J, Baselga E. Agminated fibroblastic connective tissue nevus: a new clinical presentation. Pediatr Dermatol. 2016;33(4):e240–3.

    PubMed  Google Scholar 

  37. Doyle LA, Fletcher CD. Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2013;37(4):484–95.

    PubMed  Google Scholar 

  38. Doyle LA, Marino-Enriquez A, Fletcher CDM, Hornick JL. ALK rearrangement and overexpression in epithelioid fibrous histiocytoma. Mod Pathol. 2015;28:904–12.

    CAS  PubMed  Google Scholar 

  39. Dupree WB, Enzinger FM. Fibro-osseous pseudotumor of the digits. Cancer. 1986;58:2103–9.

    CAS  PubMed  Google Scholar 

  40. Edgar MA, Lauer SR, Bridge JA, et al. Soft tissue angiofibroma: report of 2 cases of a recently described tumor. Hum Pathol. 2013;44(3):438–41.

    PubMed  Google Scholar 

  41. Erickson-Johnson MR, Chou MM, Evers BR, et al. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Investig. 2011;91(10):1427–33.

    CAS  PubMed  Google Scholar 

  42. Estela JR, Rico MT, Pérez A, Unamuno B, Garcías J, Cubells L, et al. Dermatofibroma of the face: a clinicopathologic study of 20 cases. Actas Dermosifiliogr. 2014;105(2):172–7. PMID:24275565.

    CAS  Google Scholar 

  43. Evans HL. Desmoplastic fibroblastoma. A report of 7 cases. Am J Surg Pathol. 1995;19:1077–81.

    CAS  PubMed  Google Scholar 

  44. Evans HL. Multinucleated giant cells in plantar fibromatosis. Am J Surg Pathol. 2002; 26(2):244–248. PMID:11812947.

    PubMed  Google Scholar 

  45. Fanti PA, Dika E, Piraccini BM, Infusino SD, Baraldi C, Misciali C. Superficial acral fibromyxoma: a clinicopathological and immunohistochemical analysis of 12 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. G Ital Dermatol Venereol. 2011;146(4):283–7.

    CAS  PubMed  Google Scholar 

  46. Fetsch JF, Miettinen M. Calcifying aponeurotic fibroma: a clinicopathologic study of 22 cases arising in uncommon sites. Hum Pathol. 1998;29(12):1504–10. PMID:9865839.

    CAS  PubMed  Google Scholar 

  47. Fetsch JF, Miettinen M, Laskin WB, et al. A clinicopathologic study of 45 pediatric soft tissue tumors with an admixture of adipose tissue and fibroblastic elements, and a proposal for classification as lipofibromatosis. Am J Surg Pathol. 2000;24(11):1491–500.

    CAS  PubMed  Google Scholar 

  48. Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol. 2001;32(7):704–14.

    CAS  PubMed  Google Scholar 

  49. Fetsch JF, Laskin WB, Miettinen M. Palmar-plantar fibromatosis in children and preadolescents: a clinicopathologic study of 56 cases with newly recognized demographics and extended follow-up information. Am J Surg Pathol. 2005;29(8):1095–105.

    PubMed  Google Scholar 

  50. Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103–14.

    PubMed  Google Scholar 

  51. Fletcher CD, Powell G, van Noorden S, et al. Fibrous hamartoma of infancy: a histochemical and immunohistochemical study. Histopathology. 1988;12:65–74.

    CAS  PubMed  Google Scholar 

  52. Flucke U, Shepard SJ, Bekers EM, Tirabasco R, van Diest PJ, Creytens D, van Gorp JM. Fibro-osseous pseudotumor of digits- Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement. Ann Diagn Pathol. 2018;35:53–5.

    PubMed  Google Scholar 

  53. Folpe AL, Weiss SW, Fletcher CD, et al. Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. Mod Pathol. 1998;11(10):939–44.

    CAS  PubMed  Google Scholar 

  54. Frew JW. Multinucleate cell angiohistiocytoma: clinicopathological correlation of 142 cases with insights into etiology and pathogenesis. Am J Dermatopathol. 2015;37:222–8.

    PubMed  Google Scholar 

  55. Fullen DR, Lowe L, Su LD. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cutan Pathol. 2003;30:118–22.

    PubMed  Google Scholar 

  56. Gauchotte G, Bressenot A, Serradori T, et al. Reactive nodular fibrous pseudotumor: a first report of gastric localization and clinicopathologic review. Gastroenterol Clin Biol. 2009;33(12):1076–81.

    CAS  PubMed  Google Scholar 

  57. Gleason BC, Fletcher CD. Deep “benign” fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 2008;32(3):354–62.

    PubMed  Google Scholar 

  58. Glusac EJ, Barr RJ, Everett MA, et al. Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant. Am J Surg Pathol. 1994;18(6):583–90.

    CAS  PubMed  Google Scholar 

  59. Guitart J, Bergfeld WF, Tuthill RJ. Fibrous papule of the nose with granular cells: Two cases. J Cutan Pathol. 1991;18:284–7.

    CAS  PubMed  Google Scholar 

  60. Hall LD, Ferringer T. The best diagnosis is: Eruptive xanthoma. Cutis. 2012;90(1):12, 15–6.

    Google Scholar 

  61. Hanft VN, Shea CR, McNutt NS, Pullitzer D, Horenstein MG, Prieto VG. Expression of CD34 in sclerotic (“plywood”) fibromas. Am J Dermatopathol. 2000;22(1):17–21.

    CAS  PubMed  Google Scholar 

  62. Hepple R, Kreysel HW. Cutaneous angiomyxoma: a benign neoplasm distinct from cutaneous focal mucinosis. J Am Acad Dermatol. 1995;33(2 Pt 2):352–5.

    PubMed  Google Scholar 

  63. Hernández JL, Rodríguez-Parets JO, Valero JM, Muñoz MA, Benito MR, Hernandez JM, Bullón A. High-resolution genome-wide analysis of chromosomal alterations in elastofibroma. Virchows Arch. 2010;456(6):–681, 7.

    PubMed  Google Scholar 

  64. Heymann WR. Infantile digital fibromatosis. J Am Acad Dermatol. 2008;59(1):122–3.

    PubMed  Google Scholar 

  65. Hill KA, Gonzalez-Crussi F, Omeroglu A, et al. Calcifying fibrous pseudotumor involving the neck of a five-week-old infant. Presence of factor XIIIa in the lesional cells. Pathol Res Pract. 2000;196(7):527–31.

    CAS  PubMed  Google Scholar 

  66. Hinds B, Ajello-Perez AD, LeBoit PE, McCalmont TH, North JP. Loss of retinoblastoma in pleomorphic fibroma: an immunohistochemical and genomic analysis. J Cutan Pathol. 2017;44(8):665–761.

    PubMed  Google Scholar 

  67. Hollmann TJ, Bovée JV, Fletcher CD. Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases. Am J Surg Pathol. 2012;36(6):789–98.

    PubMed  Google Scholar 

  68. Hsieh YJ, Lin YC, Wu YH, Su HY, Billings SD, Hood AF. Subungual pleomorphic fibroma. J Cutan Pathol. 2003;30(9):569–71.

    PubMed  Google Scholar 

  69. Iwata J, Fletcher CD. Lipidized fibrous histiocytoma: clinicopathologic analysis of 22 cases. Am J Dermatopathol. 2000;22(2):126–34.

    CAS  PubMed  Google Scholar 

  70. Jain A, Maheshwari V, Alam K, et al. Calcifying fibrous pseudotumor of peritoneum. J Postgrad Med. 2007;53(3):189–90.

    CAS  PubMed  Google Scholar 

  71. Jang KS, Oh YH, Han HX, et al. Calcifying fibrous pseudotumor of the pleura. Ann Thorac Surg. 2004;78(6):e87–8.

    PubMed  Google Scholar 

  72. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the Kiel pediatric tumor registry. Am J Surg Pathol. 2005;29(1):21–8.

    PubMed  Google Scholar 

  73. Jiménez-Heffernan JA, Urbano J, Tobio R, et al. Calcifying fibrous pseudotumor: a rare entity related to inflammatory pseudotumor. Acta Cytol. 2000;44(5):932–4.

    PubMed  Google Scholar 

  74. Jin Y, Möller E, Nord KH, et al. Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes. Genes Chromosomes Cancer. 2012;51(5):510–20.

    CAS  PubMed  Google Scholar 

  75. Jumper N, Paus R, Bayat A. Functional histopathology of keloid disease. Histol Histopathol. 2015;30(9):1033–57.

    CAS  PubMed  Google Scholar 

  76. Kaddu S, McMenamin ME, Fletcher CD. Atypical fibrous histiocytoma of the skin: clinicopathologic analysis of 59 cases with evidence of infrequent metastasis. Am J Surg Pathol. 2002;26(1):35–46.

    PubMed  Google Scholar 

  77. Kamino H, Jacobson M. Dermatofibroma extending into the subcutaneous tissue. Differential diagnosis from dermatofibrosarcoma protuberans. Am J Surg Pathol. 1990;14(12):1156–64.

    CAS  PubMed  Google Scholar 

  78. Kamino H, Lee JY, Berke A. Pleomorphic fibroma of the skin: a benign neoplasm with cytologic atypia. A clinical pathologic study of 8 cases. Am J Surg Pathol. 1989;13:107–13.

    CAS  PubMed  Google Scholar 

  79. Kamino H, Reddy VB, Gero M, Greco MA. Dermatomyofibroma. A benign cutaneous, plaque-like proliferation of fibroblasts and myofibroblasts in young adults. J Cutan Pathol. 1992;19:85.

    CAS  PubMed  Google Scholar 

  80. Kan AE, Rogers M. Juvenile hyaline fibromatosis: an expanded clinicopathologic spectrum. Pediatr Dermatol. 1989;6(2):68–75.

    CAS  PubMed  Google Scholar 

  81. Kato I, Yoshida A, Ikegami M, Okuma T, Tonooka A, Horiguchi S, Funata N, Kawai A, Goto T, Hishima T, Aoki I, Motoi T. FOS1 immunohistochemistry clarifies distinction between desmoplastic fibroblastoma and fibroma of tendon sheath. Histopathology. 2016;69(6):1012–20.

    PubMed  Google Scholar 

  82. Kayaselçuk F, Demirhan B, Kayaselçuk U, Ozerdem OR, Tuncer I. Vimentin, SMA, desmin, S-100 protein, p53, and estrogen receptor expression in elastofibroma and nodular fasciitis. Ann Diagn Pathol. 2002;6(2):94–9.

    PubMed  Google Scholar 

  83. Kazakov DV, Kyrpychova L, Martinek P, Grossmann P, Steiner P, Vanecek T, Pavlovsky M, Bencik V, Michal M, Michal M. ALK gene fusions in epithelioid fibrous histiocytoma: a study of 14 cases, with new histopathologic findings. Am J Dermatopathol. 2018. https://doi.org/10.1097/DAD.0000000000001085.

    PubMed  Google Scholar 

  84. Keasbey LE. Juvenile aponeurotic fibroma (calcifying fibroma); a distinctive tumor arising in the palms and soles of young children. Cancer. 1953;6(2):338–46.

    CAS  PubMed  Google Scholar 

  85. Kitano Y. Juvenile hyalin fibromatosis. Arch Dermatol. 1976;112(1):86–8.

    CAS  PubMed  Google Scholar 

  86. Kucher C, McNiff JM. Epithelial fibrous papule-a new variant. J Cutan Pathol. 2007;34:571–5.

    PubMed  Google Scholar 

  87. Kumar E, Patel NR, Demicco EG, Bovee JV, Olivera AM, Lopez-Terrada DH, Billings SD, Lazar AJ, Wang WL. Cutaneous nodular fasciitis with genetic analysis: a case series. J Cutan Pathol. 2016;43(12):1143–9.

    PubMed  Google Scholar 

  88. Kuo TT, Hu S, Chan HL. Keloidal dermatofibroma: report of 10 cases of a new variant. Am J Surg Pathol. 1998;22(5):564–8.

    CAS  PubMed  Google Scholar 

  89. Kuo TT, Chen TC, Lee LY. Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells. Pathol Int. 2009;59(12):844–50.

    PubMed  Google Scholar 

  90. Kutzner H, Mentzel T, Palmedo G, Hantschke M, Rütten A, Paredes BE, Schärer L, Guillen CS, Requena L. Plaque-like CD34 positive dermal fibroma (“medallion-like dermal dendrocyte hamartoma”): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans. Am J Surg Pathol. 2010;34(2):190–201.

    PubMed  Google Scholar 

  91. Lambert CM, Nuki G. Multicentric reticulohistiocytosis with arthritis and cardiac infiltration: regression following treatment for underlying malignancy. Ann Rheum Dis [Case Reports]. 1992;51(6):815–7.

    CAS  Google Scholar 

  92. Lamovec J, Bracko M, Voncina D. Pleomorphic fibroma of tendon sheath. Am J Surg Pathol. 1991;15:1202–5.

    CAS  PubMed  Google Scholar 

  93. Laskin WB, Miettinen M, Fetsch JF. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. Am J Surg Pathol. 2009;33(1):1–13.

    PubMed  Google Scholar 

  94. Lauer DH, Enzinger FM. Cranial fasciitis of childhood. Cancer. 1980;45(2):401–6.

    CAS  PubMed  Google Scholar 

  95. Lehmer LM, Moore JB, Ragsdale BD. Ischemic fasciitis: enhanced diagnostic resolution through clinical, histopathologic and radiologic correlation in 17 cases. J Cutan Pathol. 2016;43(9):740–8.

    PubMed  Google Scholar 

  96. Liegl B, Fletcher CD. Ischemic fasciitis: analysis of 44 cases indicating an inconsistent association with immobility or debilitation. Am J Surg Pathol. 2008;32(10):1546–52.

    PubMed  Google Scholar 

  97. Linos K, Sedivcová M, Cerna K, Sima R, Kazakov DV, Nazeer T, et al. Extra nuchal-type fibroma associated with elastosis, traumatic neuroma, a rare APC gene missense mutation, and a very rare MUTYH gene polymorphism: a case report and review of the literature. J Cutan Pathol. 2011;38(11):911–8. PMID:21752055.

    PubMed  Google Scholar 

  98. Macchia G, Trombetta D, Möller E, Mertens F, Storlazzi CT, Debeiec-Rychter M, Sciot R, Nord KH. FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma. Lab Investig. 2012;92(5):735–43.

    CAS  PubMed  Google Scholar 

  99. Maeda A, Kawabata K, Kusuzaki K. Rapid recurrence of calcifying fibrous pseudotumor (a case report). Anticancer Res. 2002;22(3):1795–7.

    PubMed  Google Scholar 

  100. Magro G, Michal M, Alaggio R, et al. Intradermal proliferative fasciitis in childhood: a potential diagnostic pitfall. J Cutan Pathol. 2011;38(1):59–62.

    PubMed  Google Scholar 

  101. Marcoval J, Moreno A, Bordas X, et al. Diffuse plane xanthoma: clinicopathologic study of 8 cases. J Am Acad Dermatol. 1998;39(3):439–42.

    CAS  PubMed  Google Scholar 

  102. Marino-Enriquez A, Fletcher CD. Angiofibroma of soft tissue: clinicopathologic characterization of a distinctive benign fibrovascular neoplasm in a series of 37 cases. Am J Surg Pathol. 2012;36(4):500–8.

    PubMed  Google Scholar 

  103. Marque M, Bessis D, Pedeutour F, Viseux V, Guillot B, Fraitag-Spinner S. Medallion-like dermal dendrocyte hamartoma: the main diagnostic pitfall is congenital atrophic dermatofibrosarcoma. Br J Dermatol. 2009;160(1):190–3.

    CAS  PubMed  Google Scholar 

  104. McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ. Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans. J Cutan Pathol. 2005;32(6):413–8.

    PubMed  Google Scholar 

  105. Mehrad M, LaFramboise WA, Lyons MA, Trejo Bittar HE, Yousem SA. Whole exome sequencing identifies unique mutations and copy number losses in calcifying fibrous tumor of the pleura: report of three cases and review of the literature. Hum Pathol. 2018. pii: S0046-8177(18)30125–4. https://doi.org/10.1016/j.humpath.2018.04.005. [Epub ahead of print].

    CAS  PubMed  Google Scholar 

  106. Meis JM, Enzinger FM. Proliferative fasciitis and myositis of childhood. Am J Surg Pathol. 1992;16(4):364–72.

    CAS  PubMed  Google Scholar 

  107. Mentzel T, Kutzner H. Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol. 2009;31:44.

    PubMed  Google Scholar 

  108. Mentzel T, Kutzner H, Rütten A, Hügel H. Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course. Am J Dermatopathol. 2001;23(5):419–26.

    CAS  PubMed  Google Scholar 

  109. Mentzel T, Wiesner T, Cerroni L, Hantschke M, Kutzner H, Rütten A, et al. Malignant dermatofibroma: clinicopathological, immunohistochemical, and molecular analysis of seven cases. Mod Pathol. 2013;26(2):256–67.

    PubMed  Google Scholar 

  110. Metcalf JS, Maize JC, LeBoit PE. Circumscribed storiform collagenoma (sclerosing fibroma). Am J Dermatopathol. 1991;13(2):122–9.

    CAS  PubMed  Google Scholar 

  111. Michael M, Fetsch JF, Hes O, Miettinen M. Nuchal-type fibroma: A clinical pathologic study 52 cases. Cancer. 1999;85(1):156–63.

    Google Scholar 

  112. Michal M, Mukensnabl P, Chlumska A, et al. Fibrous hamartoma of infancy. A study of eight cases with immunohistochemical and electron microscopical findings. Pathol Res Pract. 1992;188:1049–53.

    CAS  PubMed  Google Scholar 

  113. Miettinen M, Fetch JF. Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts. Hum Pathol. 1998;29:676–82.

    CAS  PubMed  Google Scholar 

  114. Miettinen M, Fetsch JF. Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol. 2006;30(4):521–8.

    PubMed  Google Scholar 

  115. Monaghan H, Salter DM, Al-Nafussi A. Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. J Clin Pathol. 2001;54(5):404–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  116. Montgomery EA, Meis JM. Nodular fasciitis. Its morphologic spectrum and immunohistochemical profile. Am J Surg Pathol. 1991;15(10):942–8.

    CAS  PubMed  Google Scholar 

  117. Montgomery H, Osterberg AE. Xanthomatosis: correlation of clinical histopathologic and chemical studies of cutaneous xanthoma. Arch Dermatol Syph. 1938;37:373.

    Google Scholar 

  118. Montgomery E, Lee JH, Abraham SC, Wu TT. Superficial fibromatoses are genetically distinct from deep fibromatoses. Mod Pathol. 2001;14(7):695–701. PMID:11455002.

    CAS  PubMed  Google Scholar 

  119. Moosavi CA, Al-Nahar LA, Murphey MD, Fanburg-Smith JC. Fibroosseous pseudotumor of the digit: a clinicopathologic study of 43 new cases. Ann Diagn Pathol. 2008;12(1):21–8.

    PubMed  Google Scholar 

  120. Nagamine N, Nohara Y, Ito E. Elastofibroma in Okinawa. A clinicopathologic study of 170 cases. Cancer. 1982;50(9):1794–805.

    CAS  PubMed  Google Scholar 

  121. Nascimento AG. A clinicopathologic and immunohistochemical comparative study of cutaneous and intramuscular forms of juvenile xanthogranuloma. Am J Surg Pathol. 1997;21(6):645–52.

    CAS  PubMed  Google Scholar 

  122. Nofal A, Sanad M, Assaf M, et al. Juvenile hyaline fibromatosis and infantile systemic hyalinosis: a unifying term and a proposed grading system. J Am Acad Dermatol. 2009;61(4):695–700.

    PubMed  Google Scholar 

  123. Page RN, King R, Mihm MC Jr, Googe PB. Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. Mod Pathol. 2004;17:230–4.

    CAS  PubMed  Google Scholar 

  124. Patchefsky AS, Enzinger FM. Intravascular fasciitis: a report of 17 cases. Am J Surg Pathol. 1981;5(1):29–36.

    CAS  PubMed  Google Scholar 

  125. Paties C, Vassallo G, Taccagni GL. Clear cell dermatofibroma. Am J Surg Pathol. 1997;21(2):250–2.

    CAS  PubMed  Google Scholar 

  126. Paxton CN, O’Malley DP, Bellizzi AM, Alkapalan D, Fedoriw Y, Hornick JL, Perkins SL, South ST, Andersen EF. Genetic evaluation of juvenile xanthogranuloma: genomic abnormalities are uncommon in solitary lesions, advanced cases may show more complexity. Mod Pathol. 2017;30(9):1234–40.

    CAS  PubMed  Google Scholar 

  127. Pennacchia I, Kutzner H, Kazakov DV, Mentzel T. Fibroblastic connective tissue nevus: clinicopathological and immunohistochemical study of 14 cases. J Cutan Pathol. 2017;44(10):827–34.

    PubMed  Google Scholar 

  128. Pérez LP, Zulaica A, Rodríguez L, Campo MC, Peñaranda JM, Fernández-Redondo V, et al. Multinucleate cell angiohistiocytoma. Report of five cases. J Cutan Pathol. 2006;33:349–52.

    PubMed  Google Scholar 

  129. Perosio PM, Weiss SW. Ischemic fasciitis: a juxta-skeletal fibroblastic proliferation with a predilection for elderly patients. Mod Pathol. 1993;6(1):69–72.

    CAS  PubMed  Google Scholar 

  130. Pezhouh MK, Rezaei MK, Shabihkhani M, Ghosh A, Belchis D, Montgomery EA, Voltaggio L. Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series. Hum Pathol. 2017;62:199–205.

    CAS  PubMed  Google Scholar 

  131. Pulitzer DR, Martin PC, Reed RJ. Fibroma of tendon sheath. A clinicopathologic study of 32 cases. Am J Surg Pathol. 1989;13(6):472–9.

    CAS  PubMed  Google Scholar 

  132. Puls F, Hofvander J, Magnusson L, Nilsson J, Haywood E, Sumathi VP, et al. FN1-EGF gene fusions are recurrent in calcifying aponeurotic fibroma. J Pathol. 2016;238(4):502–7. PMID:26691015.

    CAS  PubMed  Google Scholar 

  133. Rao AS, Vigorita VJ. Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases. J Bone Joint Surg Am. 1984;66(1):76–94.

    CAS  PubMed  Google Scholar 

  134. Rapini RP, Golitz LE. Sclerotic fibromas of the skin. J Am Acad Dermatol. 1989;20(2 Pt 1):266–271. PMID:2464630.

    CAS  PubMed  Google Scholar 

  135. Ravić-Nikolić A, Mladenović V, Mitrović S, Miličić V, Djukić A, Jovović-Dagović B, Savčić G. Generalized eruptive xanthomas associated with diabetic dyslipidemia. Eur J Dermatol. 2014;24(3):394–5.

    PubMed  Google Scholar 

  136. Requena L, Gutiérrez J, Sánchez Yus E. Multiple sclerotic fibromas of the skin. A cutaneous marker of Cowden’s disease. J Cutan Pathol. 1992;19(4):346–351. PMID:1430474.

    CAS  PubMed  Google Scholar 

  137. Reye RD. Recurring digital fibrous tumors of childhood. Arch Pathol. 1965;80:228–31.

    CAS  PubMed  Google Scholar 

  138. Rosa G, Billings SD. A report of three cases of pediatric proliferative fasciitis. J Cutan Pathol. 2014;41(9):720–3.

    PubMed  Google Scholar 

  139. Rougemont AL, Fetni R, Murthy S, et al. A complex translocation (6;12;8)(q25;q24.3;q13) in a fibrous hamartoma of infancy. Cancer Genet Cytogenet. 2006;171:115–8.

    CAS  PubMed  Google Scholar 

  140. Saab ST, McClain CM, Coffin CM. Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 2014;38(3):394–401.

    PubMed  Google Scholar 

  141. Sachak T, Heerema NA, Mayerson J, Payne JE, Parwani A, Iwenofu OH. Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link. Diagn Pathol. 2018;13(1):18.

    PubMed  PubMed Central  Google Scholar 

  142. Schaffer JV, Gohara MA, McNiff JM, et al. Multiple facial angiofibromas: A cutaneous manifestation of Birt–Hogg–Dubé syndrome. J Am Acad Dermatol. 2005;53:S108–11.

    PubMed  Google Scholar 

  143. Sciot R, Samson I, van den Berghe H, van Damme B, Dal CP. Collagenous fibroma (desmoplastic fibroblastoma): Genetic link with fibroma of tendon sheath? Mod Pathol. 1999a;12:565–8.

    CAS  PubMed  Google Scholar 

  144. Sciot R, Rosai J, Dal Cin P, et al. Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. Mod Pathol. 1999b;12(6):576–9.

    CAS  PubMed  Google Scholar 

  145. Shek TW, Chan AC, Ma L. Extra-nuchal nuchal fibroma. Am J Surg Pathol. 1996;20(7):902–3.

    CAS  PubMed  Google Scholar 

  146. Shimizu S, Hashimoto H, Enjoji M. Nodular fasciitis: an analysis of 250 patients. Pathology. 1984;16(2):161–6.

    CAS  PubMed  Google Scholar 

  147. Sigel JE, Smith TA, Reith JD, et al. Immunohistochemical analysis of anaplastic lymphoma kinase expression in deep soft tissue calcifying fibrous pseudotumor: evidence of a late sclerosing stage of inflammatory myofibroblastic tumor? Ann Diagn Pathol. 2001;5(1):10–4.

    CAS  PubMed  Google Scholar 

  148. Singh Gomez C, Calonje E, Fletcher CD. Epithelioid benign fibrous histiocytoma of skin: clinico-pathological analysis of 20 cases of a poorly known variant. Histopathology. 1994;24(2):123–9.

    CAS  PubMed  Google Scholar 

  149. Smith NP, Wilson JE. Multinucleate cell angiohistiocytoma: a new entity. Br J Dermatol. 1985;113:15.

    Google Scholar 

  150. Somerhausen NS, Fletcher CD. Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol. 2000;24(4):479–92.

    CAS  PubMed  Google Scholar 

  151. Soyer HP, Kutzner H, Metze D, et al. Clear-cell fibrous papule. J Cutan Pathol. 1996;23:62.

    Google Scholar 

  152. Stratton J, Billings SD. Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features. Mod Pathol. 2014;27:701–10.

    PubMed  Google Scholar 

  153. Stuart LN, Hiatt KM, Zohreh Z, Gardner JM, Shalin SC. Plaque-like CD34-positive dermal fibroma/medallion-like dendrocyte hamartoma: an unusual spindle cell neoplasm. J Cutan Pathol. 2014;41:625–9.

    PubMed  Google Scholar 

  154. Tamada S, Ackerman AB. Dermatofibroma with monster cells. Am J Dermatopathol. 1987;9(5):380–7. PMID:2825558.

    CAS  PubMed  Google Scholar 

  155. Tardío JC, Butrón M, Martín-Fragueiro LM. Superficial acral fibromyxoma: report of 4 cases with CD10 expression and lipomatous component, two previously under recognized features. Am J Dermatopathol. 2008;30(5):431–5.

    PubMed  Google Scholar 

  156. Tashakori M, Pimentl J, Howitt BE, Sanchez J, Michalowski S, Chitale D, Ormsby AH, Williamson SR. Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall. J Cutan Pathol. 2018;45(1):59–62.

    PubMed  Google Scholar 

  157. Techavichit P, Sosothikul D, Chaichana T, Teerapakpinyo C, Thorner PS, Shuangshoti S. BRAF V600E mutation in pediatric intracranial and cranial juvenile xanthogranuloma. Hum Pathol. 2017;69:118–22.

    CAS  PubMed  Google Scholar 

  158. Tran P, McLemore M. Atypical cellular neurothekeoma: a potential diagnostic pitfall for benign and malignant spindle cell lesions in skin. J Cutan Pathol. 2018. https://doi.org/10.1111/cup.13274. [Epub ahead of print].

    PubMed  Google Scholar 

  159. Tran TA, Hayner-Buchan A, Jones DM, McRorie D, Carlson JA. Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). Am J Dermatopathol. 2007;29(2):197–200.

    PubMed  Google Scholar 

  160. Ushijima M, Tsuneyoshi M, Enjoji M. Dupuytren type fibromatoses. A clinicopathologic study of 62 cases. Acta Pathol Jpn. 1984;34(5):991–1001. PMID:6507097.

    CAS  Google Scholar 

  161. Ushijima M, Hashimoto H, Tsuneyoshi M, et al. Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. Cancer. 1986;57(4):875–84.

    CAS  PubMed  Google Scholar 

  162. Val-Bernal JF, Mira C. Dermatofibroma with granular cells. J Cutan Pathol. 1996;23(6):562–5. PMID:9001988.

    Google Scholar 

  163. Van Dorpe J, Ectors N, Geboes K, et al. Is calcifying fibrous pseudotumor a late sclerosing stage of inflammatory myofibroblastic tumor? Am J Surg Pathol. 1999;23(3):329–35.

    PubMed  Google Scholar 

  164. Vanni R, Fletcher CD, Sciot R, Dal Cin P, De Wever I, Mandahl N, et al. Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: a report of the CHAMP study group. Histopathology. 2000;37(3):212–7. PMID:10971696.

    CAS  PubMed  Google Scholar 

  165. Veugelers M, Wilkes D, Burton K, McDermott DA, Song Y, Goldstein MM, et al. Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A. 2004;101(39):14222–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  166. Walther C, Hofvander J, Nilsson J, Magnusson L, Domanski HA, Gisselsson D, et al. Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing. Lab Investig. 2015;95(9):1071–6. PMID:26121314.

    CAS  PubMed  Google Scholar 

  167. Wambacher-Gasser B, Zelger B, Zelger BG, Steiner H. Clear cell dermatofibroma. Histopathology. 1997;30(1):64–9. PMID:9023559.

    PubMed  Google Scholar 

  168. Wang GY, Nazarian RM, Zhao L, Hristov AC, Patel RM, Fullen DR, Chan MP. Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma. Pathology. 2017;49(1):44–9.

    PubMed  Google Scholar 

  169. Wehrli BM, Weiss SW, Yandow S, Coffin CM. Gardner associated fibromas (GAF) in young patients: A distinct fibrous lesion that identifies unsuspected Gardner’s syndrome and risk for fibromatosis. Am J Surg Pathol. 2001;25(5):645–51.

    CAS  PubMed  Google Scholar 

  170. Weinreb I, Shaw AJ, Perez-Ordoñez B, et al. Nodular fasciitis of the head and neck region: a clinicopathologic description in a series of 30 cases. J Cutan Pathol. 2009;36(11):1168–73.

    PubMed  Google Scholar 

  171. West RB, Rubin BP, Miller MA, et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A. 2006;103(3):690–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  172. Winkelmann RK. Cutaneous syndromes of non-X histiocytosis. A review of the macrophage-histiocyte diseases of the skin. Arch Dermatol. 1981;117(10):667–72.

    CAS  PubMed  Google Scholar 

  173. Yamada Y, Yamamoto H, Kohashi K, Ishii T, Iura K, Maekawa A, Bekki H, Otsuka H, Yamashita K, Tanaka H, Hiraki T, Mukai M, Shirakawa A, Shinnou Y, Jinno M, Yanai H, Taguchi K, Maehara Y, Iwamoto Y, Oda Y. Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases. Histopathology. 2016;69(3):459–69.

    PubMed  Google Scholar 

  174. Yamawaki S, Naitoh M, Kubota H, Aya R, Katayama Y, Ishiko T, Tamura T, Yoshikawa K, Enoshiri T, Ikeda M, Suzuki S. Htra1 is specifically up-regulated in active keloid lesions and stimulates keloid development. Int J Mol Sci. 2018;19(5):pii: E1275.

    Google Scholar 

  175. Yantiss RK, Nielsen GP, Lauwers GY, et al. Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery: a clinicopathologic study of five cases. Am J Surg Pathol. 2003;27(4):532–40.

    PubMed  Google Scholar 

  176. Zelger B, Cerio R, Soyer HP, et al. Reticulohistiocytoma and multicentric reticulohistiocytosis. Histopathologic and immunophenotypic distinct entities. Am J Dermatopathol [Comparative Study]. 1994;16(6):577–84.

    CAS  Google Scholar 

  177. Zelger BW, Zelger BG, Steiner H, Ofner D. Aneurysmal and haemangiopericytoma-like fibrous histiocytoma. J Clin Pathol. 1996;49(4):313–8.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Rajiv M. Patel & Aaron M. Udager

  2. Department of Pathology, Oregon Health and Science University School of Medicine, Portland, OR, USA

    Reena Singh

  3. Department of Pathology, Cleveland Clinic, Cleveland, OH, USA

    Steven D. Billings

Authors
  1. Rajiv M. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reena Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aaron M. Udager
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Steven D. Billings
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rajiv M. Patel .

Editor information

Editors and Affiliations

  1. Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA

    Steven D. Billings

  2. Departments of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USA

    Rajiv M. Patel

  3. Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison, Madison, WI, USA

    Darya Buehler

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Science+Business Media, LLC, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Patel, R.M., Singh, R., Udager, A.M., Billings, S.D. (2019). Benign Fibrous, Fibrohistiocytic, and Myofibroblastic Lesions. In: Billings, S., Patel, R., Buehler, D. (eds) Soft Tissue Tumors of the Skin. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8812-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-8812-9_4

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-8810-5

  • Online ISBN: 978-1-4939-8812-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation