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The Neurobiology of Adolescent-Onset Borderline Personality Disorder

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Handbook of Borderline Personality Disorder in Children and Adolescents

Abstract

Clarifying the underlying biology of BPD, including the etiological mechanisms, genetic factors, and pathological processes is essential for a full understanding of the disorder and provides a basis for the development of more effective treatment intervention and preventive strategies (Beauchaine, Hong, & Marsh, 2008; Chanen & Kaess, 2012). Over the past two decades, neurobiological studies in adult BPD have made important strides, but inquiry into adolescent-onset BPD is still in its infancy. This chapter will review findings in populations both of adult and adolescent-onset BPD pertaining to genetics, oxytocin, opioids, neuroendocrine measures, evoked potentials and neuroimaging.

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References

  • Balanzá-Martínez, V., Rubio, C., Selva-Vera, G., Martinez-Aran, A., Sánchez-Moreno, J., Salazar-Fraile, J., et al. (2008). Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: A systematic review. Neuroscience and Biobehavioral Reviews, 32(8), 1426–1438. doi:10.1016/j.neubiorev.2008.05.019.

    PubMed  Google Scholar 

  • Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., et al. (2011). Oxytocin can hinder trust and cooperation in borderline personality disorder. Social Cognitive and Affective Neuroscience, 6(5), 556–563. doi:10.1093/scan/nsq085.

    PubMed Central  PubMed  Google Scholar 

  • Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Science, 15(7), 301–309. doi:10.1016/j.tics.2011.05.002.

    Google Scholar 

  • Bateman, A., & Fonagy, P. (2010). Mentalization based treatment for borderline personality disorder. World Psychiatry, 9(1), 11–15.

    PubMed Central  PubMed  Google Scholar 

  • Beauchaine, T. P., Hong, J., & Marsh, P. (2008). Sex differences in autonomic correlates of conduct problems and aggression. Journal of the American Academy of Child and Adolescent Psychiatry, 47(7), 788–796. doi:10.1097/CHI.Ob013e318172ef4b.

    PubMed Central  PubMed  Google Scholar 

  • Bernstein, D. P., Cohen, P., Velez, C. N., Schwab-Stone, M., Siever, L. J., & Shinsato, L. (1993). Prevalence and stability of the DSM-III-R personality disorders in a community-based survey of adolescents. The American Journal of Psychiatry, 150(8), 1237–1243.

    PubMed  Google Scholar 

  • Bos, P. A., Panksepp, J., Bluthe, R. M., & van Honk, J. (2012). Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies. Frontiers in Neuroendocrinology, 33(1), 17–35. doi:10.1016/j.yfrne.2011.01.002.

    PubMed  Google Scholar 

  • Brambilla, P., Soloff, P. H., Sala, M., Nicoletti, M. A., Keshavan, M. S., & Soares, J. C. (2004). Anatomical MRI study of borderline personality disorder patients. Psychiatry Research, 131(2), 125–133. doi:10.1016/j.pscychresns.2004.04.003.

    PubMed  Google Scholar 

  • Brunner, R., Henze, R., Parzer, P., Kramer, J., Feigl, N., Lutz, K., et al. (2010). Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: Is it disorder specific? NeuroImage, 49(1), 114–120. doi:10.1016/j.neuroimage.2009.07.070.

    PubMed  Google Scholar 

  • Burket, R. C., & Myers, W. C. (1995). Axis I and personality comorbidity in adolescents with conduct disorder. The Bulletin of the American Academy of Psychiatry and the Law, 23(1), 73–82.

    PubMed  Google Scholar 

  • Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., et al. (2003). Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry, 44(2), 88–101. doi:10.1053/comp.2003.50018.

    PubMed  Google Scholar 

  • Carrasco, J. L., Díaz-Marsá, M., Pastrana, J. I., Molina, R., Brotons, L., López-Ibor, M. I., et al. (2007). Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features. The British Journal of Psychiatry, 190, 357–358. doi:10.1192/bjp.bp.106.022590.

    PubMed  Google Scholar 

  • Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science (New York, N.Y.), 301(5631), 386–389. doi:10.1126/science.1083968.

    Google Scholar 

  • Ceballos, N. A., Houston, R. J., Hesselbrock, V. M., & Bauer, L. O. (2006). Brain maturation in conduct disorder versus borderline personality disorder. Neuropsychobiology, 53(2), 94–100. doi:10.1159/000092217.

    PubMed  Google Scholar 

  • Chanen, A. M., Jackson, H. J., McCutcheon, L. K., Jovev, M., Dudgeon, P., Yuen, H. P., et al. (2008). Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: Randomized controlled trial. The British Journal of Psychiatry, 193(6), 477–484. doi:10.1192/bjp.bp.107.048934.

    PubMed  Google Scholar 

  • Chanen, A. M., Jackson, H. J., McGorry, P. D., Allot, K. A., Clarkson, V., & Yuen, H. P. (2004). Two-year stability of personality disorder in older adolescent outpatients. Journal of Personality Disorders, 18(6), 526–541. doi:10.1521/pedi.18.6.526.54798.

    PubMed  Google Scholar 

  • Chanen, A. M., & Kaess, M. (2012). Developmental pathways to borderline personality disorder. Current Psychiatry Report, 14(1), 45–53. doi:10.1007/s11920-011-0242-y.

  • Chanen, A. M., Velakoulis, D., Carison, K., Gaunson, K., Wood, S. J., Yuen, H. P., et al. (2008). Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Research, 163(2), 116–125. doi:10.1016/j.pscychresns.2007.08.007.

    PubMed  Google Scholar 

  • Coccaro, E. F., McCloskey, M. S., Fitzgerald, D. A., & Phan, K. L. (2007). Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biological Psychiatry, 62(2), 168–178. doi:10.1016/j.biopsych.2006.08.024.

    PubMed  Google Scholar 

  • Collins, F. S., Brooks, L. D., & Chakravarti, A. (1998). A DNA polymorphism discovery resource for research on human genetic variation. Genome Research, 8(12), 1229–1231.

    PubMed  Google Scholar 

  • Crawford, T. N., Cohen, P., First, M. B., Skodol, A. E., Johnson, J. G., & Kasen, S. (2008). Comorbid Axis I and Axis II disorders in early adolescence: Outcomes 20 years later. Archives of General Psychiatry, 65(6), 641–648. doi:10.1001/archpsyc.65.6.641.

    PubMed  Google Scholar 

  • da Rocha, F. F., Malloy-Diniz, L., de Sousa, K. C. A., Prais, H. A. C., Correa, H., & Teixeira, A. L. (2008). Borderline personality features possibly related to cingulate and orbitofrontal cortices dysfunction due to schizencephaly. Clinical Neurology and Neurosurgery, 110(4), 396–399. doi:10.1016/j.clineuro.2007.12.009.

    PubMed  Google Scholar 

  • Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G., & Boomsma, D. I. (2011). Life events and borderline personality features: The influence of gene-environment interaction and gene-environment correlation. Psychological Medicine, 41(4), 849–860. doi:10.1017/S0033291710001297.

    PubMed  Google Scholar 

  • Donegan, N. H., Sanislow, C. A., Blumberg, H. P., Fulbright, R. K., Lacadie, C., Skudlarski, P., et al. (2003). Amygdala hyperreactivity in borderline personality disorder: Implications for emotional dysregulation. Biological Psychiatry, 54(11), 1284–1293.

    PubMed  Google Scholar 

  • Driessen, M., Herrmann, J., Stahl, K., Zwaan, M., Meier, S., Hill, A., et al. (2000). Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry, 57(12), 1115–1122.

    PubMed  Google Scholar 

  • Dziobek, I., Fleck, S., Kalbe, E., Rogers, K., Hassenstab, J., Brand, M., et al. (2006). Introducing MASC: A movie for the assessment of social cognition. Journal of Autism and Developmental Disorders, 36(5), 623–636. doi:10.1007/s10803-006-0107-0.

    PubMed  Google Scholar 

  • Dziobek, I., Preissler, S., Grozdanovic, Z., Heuser, I., Heekeren, H. R., & Roepke, S. (2011). Neuronal correlates of altered empathy and social cognition in borderline personality disorder. NeuroImage, 57(2), 539–548. doi:10.1016/j.neuroimage.2011.05.005.

    PubMed  Google Scholar 

  • Eisenberg, N., & Miller, P. A. (1987). The relation of empathy to prosocial and related behaviors. Psychological Bulletin, 101(1), 91–119.

    PubMed  Google Scholar 

  • Frankle, W. G., Lombardo, I., New, A. S., Goodman, M., Talbot, P. S., Huang, Y., et al. (2005). Brain serotonin transporter distribution in subjects with impulsive aggressivity: A positron emission study with [11C]McN 5652. The American Journal of Psychiatry, 162(5), 915–923. doi:10.1176/appi.ajp.162.5.915.

    PubMed  Google Scholar 

  • Garner, B., Chanen, A. M., Phillips, L., Velakoulis, D., Wood, S. J., Jackson, H. J., et al. (2007). Pituitary volume in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging, 156(3), 257–261.

    PubMed  Google Scholar 

  • Goodman, M., Hazlett, E. A., Avedon, J. B., Siever, D. R., Chu, K.-W., & New, A. S. (2011). Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression. Journal of Psychiatric Research, 45(6), 803–807. doi:10.1016/j.jpsychires.2010.11.011.

    PubMed  Google Scholar 

  • Goodman, M., New, A. S., Triebwasser, J., Collins, K. A., & Siever, L. (2010). Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder. Journal of Personality Disorders, 24(1), 38–59. doi:10.1521/pedi.2010.24.1.38.

    PubMed  Google Scholar 

  • Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. The American Journal of Psychiatry, 160(4), 636–645.

    PubMed  Google Scholar 

  • Grilo, C. M., Becker, D. F., Fehon, D. C., Walker, M. L., Edell, W. S., & McGlashan, T. H. (1996). Gender differences in personality disorders in psychiatrically hospitalized adolescents. The American Journal of Psychiatry, 153(8), 1089–1091.

    PubMed  Google Scholar 

  • Grossman, R., Yehuda, R., New, A., Schmeidler, J., Silverman, J., Mitropoulou, V., et al. (2003). Dexamethasone suppression test findings in subjects with personality disorders: Associations with posttraumatic stress disorder and major depression. The American Journal of Psychiatry, 160(7), 1291–1298.

    PubMed  Google Scholar 

  • Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., et al. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67(7), 692–694.

    PubMed  Google Scholar 

  • Guastella, A. J., & MacLeod, C. (2012). A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions. Hormones and Behavior, 61(3), 410–418. doi:10.1016/j.yhbeh.2012.01.002.

    PubMed  Google Scholar 

  • Hankin, B. L., Barrocas, A. L., Jenness, J., Oppenheimer, C. W., Badanes, L. S., Abela, J. R. Z., et al. (2011). Association between 5-HTTLPR and borderline personality disorder traits among youth. Frontiers in Psychiatry/Frontiers Research Foundation, 2, 6. doi:10.3389/fpsyt.2011.00006.

    Google Scholar 

  • Hazlett, E. A., New, A. S., Newmark, R., Haznedar, M. M., Lo, J. N., Speiser, L. J., et al. (2005). Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biological Psychiatry, 58(8), 614–623. doi:10.1016/j.biopsych.2005.04.029.

    PubMed  Google Scholar 

  • Hazlett, E. A., Speiser, L. J., Goodman, M., Roy, M., Carrizal, M., Wynn, J. K., et al. (2007). Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder. Biological Psychiatry, 62(3), 250–255. doi:10.1016/j.biopsych.2006.10.028.

    PubMed  Google Scholar 

  • Hazlett, E. A., Zhang, J., New, A. S., Zelmanova, Y., Goldstein, K. E., Haznedar, M. M., et al. (2012). Potentiated amygdala response to repeated emotional pictures in borderline personality disorder. Biological Psychiatry, 72(6), 448–456.

    PubMed Central  PubMed  Google Scholar 

  • Houston, R. J., Bauer, L. O., & Hesselbrock, V. M. (2004). Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. International Journal of Psychophysiology, 53(1), 57–70.

    PubMed  Google Scholar 

  • Houston, R. J., Ceballos, N. A., Hesselbrock, V. M., & Bauer, L. O. (2005). Borderline personality disorder features in adolescent girls: P300 evidence of altered brain maturation. Clinical Neurophysiology, 116(6), 1424–1432. doi:10.1016/j.clinph.2005.01.013.

    PubMed  Google Scholar 

  • Irle, E., Lange, C., & Sachsse, U. (2005). Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biological Psychiatry, 57(2), 173–182. doi:10.1016/j.biopsych.2004.10.004.

    PubMed  Google Scholar 

  • Johansson, A., Westberg, L., Sandnabba, K., Jern, P., Salo, B., & Santtila, P. (2012). Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology, 37(9), 1546–1556. doi:10.1016/j.psyneuen.2012.02.009.

    PubMed  Google Scholar 

  • Jovev, M., Garner, B., Phillips, L., Velakoulis, D., Wood, S. J., Jackson, H. J., et al. (2008). An MRI study of pituitary volume and parasuicidal behavior in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging, 162(3), 273–277.

    PubMed  Google Scholar 

  • Kaess, M., Hille, M., Parzer, P., Maser-Gluth, C., Resch, F., & Brunner, R. (2012). Alterations in the neuroendocrinological stress response to acute psychosocial stress in adolescents engaging in nonsuicidal self-injury. Psychoneuroendocrinology, 37(1), 157–161. doi:10.1016/j.psyneuen.2011.05.009.

    PubMed  Google Scholar 

  • Kendler, K. S. (1995). Genetic epidemiology in psychiatry. Taking both genes and environment seriously. Archives of General Psychiatry, 52(11), 895–899.

    PubMed  Google Scholar 

  • Kendler, K. S., Aggen, S. H., Czajkowski, N., Roysamb, E., Tambs, K., Torgersen, S., et al. (2008). The structure of genetic and environmental risk factors for DSM-IV personality disorders: A multivariate twin study. Archives of General Psychiatry, 65(12), 1438–1446. doi:65/12/1438 [pii].

    Google Scholar 

  • Kendler, K. S., Myers, J., & Reichborn-Kjennerud, T. (2011). Borderline personality disorder traits and their relationship with dimensions of normative personality: A web-based cohort and twin study. Acta Psychiatrica Scandinavica, 123(5), 349–359. doi:10.1111/j.1600-0447.2010.01653.x.

    PubMed Central  PubMed  Google Scholar 

  • Lange, C., Kracht, L., Herholz, K., Sachsse, U., & Irle, E. (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research, 139(2), 115–126. doi:10.1016/j.pscychresns.2005.05.003.

    PubMed  Google Scholar 

  • Lange, W., Wulff, H., Berea, C., Beblo, T., Saavedra, A. S., Mensebach, C., et al. (2005). Dexamethasone suppression test in borderline personality disorder—effects of posttraumatic stress disorder. Psychoneuroendocrinology, 30(9), 919–923. doi:10.1016/j.psyneuen.2005.02.009.

    PubMed  Google Scholar 

  • Leichsenring, F., Leibing, E., Kruse, J., New, A. S., & Leweke, F. (2011). Borderline personality disorder. Lancet, 377(9759), 74–84. doi: S0140-6736(10)61422-5 [pii] 1016/S0140–6736(10)61422–5 [doi].

    PubMed  Google Scholar 

  • Lewinsohn, P. M., Rohde, P., Seeley, J. R., & Klein, D. N. (1997). Axis II psychopathology as a function of Axis I disorders in childhood and adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 36(12), 1752–1759. doi:10.1097/00004583-199712000-00024.

    PubMed  Google Scholar 

  • Leyton, M., Okazawa, H., Diksic, M., Paris, J., Rosa, P., Mzengeza, S., et al. (2001). Brain regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. The American Journal of Psychiatry, 158(5), 775–782.

    PubMed  Google Scholar 

  • Lis, S., & Bohus, M. (2013). Social interaction in borderline personality disorder. Current Psychiatry Reports, 15(2), 338. doi:10.1007/s11920-012-0338-z.

    PubMed  Google Scholar 

  • Love, T. M., Enoch, M. A., Hodgkinson, C. A., Pecina, M., Mickey, B., Koeppe, R. A., et al. (2012). Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biological Psychiatry, 72(3), 198–206. doi:10.1016/j.biopsych.2012.01.033.

    PubMed Central  PubMed  Google Scholar 

  • Macdonald, K., & Macdonald, T. M. (2009). The peptide that binds: A systematic review of oxytocin and its prosocial effects in humans. Harvard Review of Psychiatry, 18(1), 1–21.

    Google Scholar 

  • Mak, A. D., & Lam, L. C. (2013). Neurocognitive profiles of people with borderline personality disorder. Current Opinion in Psychiatry, 26(1), 90–96. doi:10.1097/YCO.0b013e32835b57a9.

    PubMed  Google Scholar 

  • Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H. (2012). The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes, Brain, and Behavior, 11(5), 545–551. doi:10.1111/j.1601-183X.2012.00776.x.

    PubMed  Google Scholar 

  • Meares, R., Schore, A., & Melkonian, D. (2011). Is borderline personality a particularly right hemispheric disorder? A study of P3a using single trial analysis. The Australian and New Zealand Journal of Psychiatry, 45(2), 131–139. doi:10.3109/00048674.2010.497476.

    PubMed  Google Scholar 

  • Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12(9), 524–538. doi:10.1038/nrn3044.

    PubMed  Google Scholar 

  • Minzenberg, M. J., Fan, J., New, A. S., Tang, C. Y., & Siever, L. J. (2007). Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: An event-related fMRI study. Psychiatry Research, 155(3), 231–243. doi:10.1016/j.pscychresns.2007.03.006.

    PubMed Central  PubMed  Google Scholar 

  • Minzenberg, M. J., Fan, J., New, A. S., Tang, C. Y., & Siever, L. J. (2008). Frontolimbic structural changes in borderline personality disorder. Journal of Psychiatric Research, 42(9), 727–733. doi:10.1016/j.jpsychires.2007.07.015.

    PubMed Central  PubMed  Google Scholar 

  • New, A. S., Goodman, M., Triebwasser, J., & Siever, L. J. (2008). Recent advances in the biological study of personality disorders. The Psychiatric Clinics of North America, 31(3), 441–461, vii. doi:S0193-953X(08)00035-X [pii].

    Google Scholar 

  • New, A. S., Hazlett, E. A., Buchsbaum, M. S., Goodman, M., Mitelman, S. A., Newmark, R., et al. (2007). Amygdala-prefrontal disconnection in borderline personality disorder. Neuropsychopharmacology, 32(7), 1629–1640. doi:10.1038/sj.npp.1301283.

    PubMed  Google Scholar 

  • New, A. S., Hazlett, E. A., Buchsbaum, M. S., Goodman, M., Reynolds, D., Mitropoulou, V., et al. (2002). Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression. Archives of General Psychiatry, 59(7), 621–629.

    PubMed  Google Scholar 

  • New, A. S., & Stanley, B. (2010). An opioid deficit in borderline personality disorder: Self-cutting, substance abuse, and social dysfunction. American Journal of Psychiatry, 167(8), 882–885.

    PubMed  Google Scholar 

  • Ni, X., Bismil, R., Chan, K., Sicard, T., Bulgin, N., McMain, S., et al. (2006). Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. Neuroscience Letters, 408(3), 214–219. doi:10.1016/j.neulet.2006.09.002.

    PubMed  Google Scholar 

  • Ni, X., Chan, K., Bulgin, N., Sicard, T., Bismil, R., McMain, S., et al. (2006). Association between serotonin transporter gene and borderline personality disorder. Journal of Psychiatric Research, 40(5), 448–453. doi:10.1016/j.jpsychires.2006.03.010.

    PubMed  Google Scholar 

  • Ni, X., Chan, D., Chan, K., McMain, S., & Kennedy, J. L. (2009). Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(1), 128–133.

    PubMed  Google Scholar 

  • Ni, X., Sicard, T., Bulgin, N., Bismil, R., Chan, K., McMain, S., et al. (2007). Monoamine oxidase A gene is associated with borderline personality disorder. Psychiatric Genetics, 17(3), 153–157.

    PubMed  Google Scholar 

  • Paris, J. (2005). The diagnosis of borderline personality disorder: Problematic but better than the alternatives. Annals of Clinical Psychiatry, 17(1), 41–46.

    PubMed  Google Scholar 

  • Pascual, J. C., Soler, J., Barrachina, J., Campins, M. J., Alvarez, E., Perez, V., et al. (2008). Failure to detect an association between the serotonin transporter gene and borderline personality disorder. Journal of Psychiatric Research, 42(1), 87–88.

    PubMed  Google Scholar 

  • Perez-Rodriguez, M. M., Weinstein, S., New, A. S., Bevilacqua, L., Yuan, Q., Zhou, Z., et al. (2010). Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. Journal of Psychiatric Research, 44(15), 1075–1081. doi:10.1016/j.jpsychires.2010.03.014.

    PubMed Central  PubMed  Google Scholar 

  • Plomin, R., Owen, M. J., & McGuffin, P. (1994). The genetic basis of complex human behaviors. Science (New York, N.Y.), 264(5166), 1733–1739.

    Google Scholar 

  • Prossin, A. R., Love, T. M., Koeppe, R. A., Zubieta, J. K., & Silk, K. R. (2010). Dysregulation of regional endogenous opioid function in borderline personality disorder. American Journal of Psychiatry, 167(8), 925–933.

    PubMed  Google Scholar 

  • Ragnauth, A. K., Devidze, N., Moy, V., Finley, K., Goodwillie, A., Kow, L. M., et al. (2005). Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes, Brain, and Behavior, 4(4), 229–239. doi:10.1111/j.1601-183X.2005.00118.x.

    PubMed  Google Scholar 

  • Rinne, T., de Kloet, E. R., Wouters, L., Goekoop, J. G., DeRijk, R. H., & van den Brink, W. (2002). Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biological Psychiatry, 52(11), 1102–1112.

    PubMed  Google Scholar 

  • Ruocco, A. C., Amirthavasagam, S., Choi-Kain, L. W., & McMain, S. F. (2012). Neural correlates of negative emotionality in borderline personality disorder: An activation-likelihood-estimation meta-analysis. Biological Psychiatry, 73(2), 153–160. doi:10.1016/j.biopsych.2012.07.014.

  • Rüsch, N., Luders, E., Lieb, K., Zahn, R., Ebert, D., Thompson, P. M., et al. (2007). Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Journal of Psychiatry & Neuroscience, 32(6), 417–422.

    Google Scholar 

  • Schmahl, C., Bohus, M., Esposito, F., Treede, R.-D., Di Salle, F., Greffrath, W., et al. (2006). Neural correlates of antinociception in borderline personality disorder. Archives of General Psychiatry, 63(6), 659–667. doi:10.1001/archpsyc.63.6.659.

    PubMed  Google Scholar 

  • Schmahl, C. G., Vermetten, E., Elzinga, B. M., & Douglas Bremner, J. (2003). Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Research, 122(3), 193–198.

    PubMed  Google Scholar 

  • Schnell, K., Dietrich, T., Schnitker, R., Daumann, J., & Herpertz, S. C. (2007). Processing of autobiographical memory retrieval cues in borderline personality disorder. Journal of Affective Disorders, 97(1–3), 253–259. doi:10.1016/j.jad.2006.05.035.

    PubMed  Google Scholar 

  • Schuermann, B., Kathmann, N., Stiglmayr, C., Renneberg, B., & Endrass, T. (2011). Impaired decision making and feedback evaluation in borderline personality disorder. Psychological Medicine, 41(9), 1917–1927. doi:10.1017/S003329171000262X.

    PubMed  Google Scholar 

  • Sen, S., Villafuerte, S., Nesse, R., Stoltenberg, S. F., Hopcian, J., Gleiberman, L., et al. (2004). Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biological Psychiatry, 55(3), 244–249.

    PubMed  Google Scholar 

  • Sharp, C., Pane, H., Ha, C., Venta, A., Patel, A. B., Sturek, J., et al. (2011). Theory of mind and emotion regulation difficulties in adolescents with borderline traits. Journal of the American Academy of Child and Adolescent Psychiatry, 50(6), 563–573 e561. doi:10.1016/j.jaac.2011.01.017.

    PubMed  Google Scholar 

  • Sher, L., & Stanley, B. H. (2009). Biological models of nonsuicidal self-injury. In M. K. Nock (Ed.), Understanding nonsuicidal self-injury: Origins, assessment and treatment. Washington, DC: American Psychological Association.

    Google Scholar 

  • Siegle, G. J. (2007). Brain mechanisms of borderline personality disorder at the intersection of cognition, emotion, and the clinic. The American Journal of Psychiatry, 164(12), 1776–1779. doi:10.1176/appi.ajp.2007.07091505.

    PubMed  Google Scholar 

  • Siever, L. J., Buchsbaum, M. S., New, A. S., Spiegel-Cohen, J., Wei, T., Hazlett, E. A., et al. (1999). d, l-Fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology, 20(5), 413–423. doi:10.1016/S0893-133X(98)00111-0.

    PubMed  Google Scholar 

  • Silbersweig, D., Clarkin, J. F., Goldstein, M., Kernberg, O. F., Tuescher, O., Levy, K. N., et al. (2007). Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. The American Journal of Psychiatry, 164(12), 1832–1841. doi:10.1176/appi.ajp.2007.06010126.

    PubMed  Google Scholar 

  • Simeon, D., Bartz, J., Hamilton, H., Crystal, S., Braun, A., Ketay, S., et al. (2011). Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study. Psychoneuroendocrinology, 36(9), 1418–1421. doi:10.1016/j.psyneuen.2011.03.013.

    PubMed  Google Scholar 

  • Soloff, P. H., Meltzer, C. C., Becker, C., Greer, P. J., Kelly, T. M., & Constantine, D. (2003). Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Research, 123(3), 153–163.

    PubMed  Google Scholar 

  • Soloff, P. H., Price, J. C., Meltzer, C. C., Fabio, A., Frank, G. K., & Kaye, W. H. (2007). 5HT2A receptor binding is increased in borderline personality disorder. Biological Psychiatry, 62(6), 580–587. doi:10.1016/j.biopsych.2006.10.022.

    PubMed  Google Scholar 

  • Stanley, B., & Siever, L. J. (2010). The interpersonal dimension of borderline personality disorder: Toward a neuropeptide model. The American Journal of Psychiatry, 167(1), 24–39. doi:appi.ajp.2009.09050744 [pii] 10.1176/appi.ajp.2009.09050744 [doi].

    Google Scholar 

  • Stoffers, J. M., Vollm, B. A., Rucker, G., Timmer, A., Huband, N., & Lieb, K. (2012). Psychological therapies for people with borderline personality disorder. Cochrane Database of Systematic Reviews, 8, CD005652. doi:10.1002/14651858.CD005652.pub2.

    PubMed  Google Scholar 

  • Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., et al. (2013). Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 23(2), 123–127. doi:10.1089/cap.2012.0048.

    PubMed  Google Scholar 

  • Takahashi, T., Chanen, A. M., Wood, S. J., Walterfang, M., Harding, I. H., Yücel, M., et al. (2009). Midline brain structures in teenagers with first-presentation borderline personality disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(5), 842–846. doi:10.1016/j.pnpbp.2009.03.035.

    Google Scholar 

  • Takahashi, T., Chanen, A. M., Wood, S. J., Yücel, M., Kawasaki, Y., McGorry, P. D., et al. (2010). Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder. Psychiatry Research, 182(1), 73–76. doi:10.1016/j.pscychresns.2009.10.014.

    PubMed  Google Scholar 

  • Takahashi, T., Chanen, A. M., Wood, S. J., Yücel, M., Tanino, R., Suzuki, M., et al. (2009). Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(8), 1395–1400. doi:10.1016/j.pnpbp.2009.07.017.

    Google Scholar 

  • Torgersen, S. (2000). Genetics of patients with borderline personality disorder. The Psychiatric Clinics of North America, 23(1), 1–9.

    PubMed  Google Scholar 

  • Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., et al. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13936–13941. doi:10.1073/pnas.1003296107.

    PubMed Central  PubMed  Google Scholar 

  • Walter, M., Bureau, J.-F., Holmes, B. M., Bertha, E. A., Hollander, M., Wheelis, J., et al. (2008). Cortisol response to interpersonal stress in young adults with borderline personality disorder: A pilot study. European Psychiatry, 23(3), 201–204. doi:10.1016/j.eurpsy.2007.12.003.

    PubMed Central  PubMed  Google Scholar 

  • Walterfang, M., Chanen, A. M., Barton, S., Wood, A. G., Jones, S., Reutens, D. C., et al. (2010). Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder. Psychiatry Research: Neuroimaging, 183(1), 30–37.

    PubMed  Google Scholar 

  • Whittle, S., Chanen, A. M., Fornito, A., McGorry, P. D., Pantelis, C., & Yücel, M. (2009). Anterior cingulate volume in adolescents with first-presentation borderline personality disorder. Psychiatry Research, 172(2), 155–160. doi:10.1016/j.pscychresns.2008.12.004.

    PubMed  Google Scholar 

  • Wilson, S. T., Stanley, B., Brent, D. A., Oquendo, M. A., Huang, Y., & Mann, J. J. (2009). The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 150B(2), 202–208. doi:10.1002/ajmg.b.30788.

    Google Scholar 

  • Wong, A. H. C., Gottesman, I. I., & Petronis, A. (2005). Phenotypic differences in genetically identical organisms: The epigenetic perspective. Human Molecular Genetics, 14 Spec No 1, R11–R18. doi:10.1093/hmg/ddi116.

  • Wu, N., Li, Z., & Su, Y. (2012). The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Journal of Affective Disorders, 138(3), 468–472. doi:10.1016/j.jad.2012.01.009.

    PubMed  Google Scholar 

  • Zaboli, G., Gizatullin, R., Nilsonne, A., Wilczek, A., Jönsson, E. G., Ahnemark, E., et al. (2006). Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women. Neuropsychopharmacology, 31(9), 1982–1990. doi:10.1038/sj.npp.1301046.

    PubMed  Google Scholar 

  • Zanetti, M. V., Soloff, P. H., Nicoletti, M. A., Hatch, J. P., Brambilla, P., Keshavan, M. S., et al. (2007). MRI study of corpus callosum in patients with borderline personality disorder: A pilot study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31(7), 1519–1525. doi:10.1016/j.pnpbp.2007.07.013.

    Google Scholar 

  • Zetzsche, T., Frodl, T., Preuss, U. W., Schmitt, G., Seifert, D., Leinsinger, G., et al. (2006). Amygdala volume and depressive symptoms in patients with borderline personality disorder. Biological Psychiatry, 60(3), 302–310. doi:10.1016/j.biopsych.2005.11.020.

    PubMed  Google Scholar 

  • Zetzsche, T., Preuss, U. W., Frodl, T., Schmitt, G., Seifert, D., Münchhausen, E., et al. (2007). Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder. Psychiatry Research, 154(2), 157–170. doi:10.1016/j.pscychresns.2006.05.010.

    PubMed  Google Scholar 

  • Zink, C. F., & Meyer-Lindenberg, A. (2012). Human neuroimaging of oxytocin and vasopressin in social cognition. Hormones and Behavior, 61(3), 400–409. doi:10.1016/j.yhbeh.2012.01.016.

    PubMed Central  PubMed  Google Scholar 

Recommended Reading

  • Chanen, A. M., & Kaess, M. (2012). Developmental pathways to borderline personality disorder. Current Psychiatry Report, 14(1), 45–53. doi: 10.1007/s11920-011-0242-y.

  • Kendler, K. S., Aggen, S. H., Czajkowski, N., Roysamb, E., Tambs, K., Torgersen, S., et al. (2008). The structure of genetic and environmental risk factors for DSM-IV personality disorders: A multivariate twin study. Archives of General Psychiatry, 65(12), 1438–1446. doi: 65/12/1438 [pii].

    Google Scholar 

  • New, A. S., Goodman, M., Triebwasser, J., & Siever, L. J. (2008). Recent advances in the biological study of personality disorders. The Psychiatric Clinics of North America, 31(3), 441–461, vii. doi: S0193-953X(08)00035-X [pii].

    Google Scholar 

  • Ruocco, A. C., Amirthavasagam, S., Choi-Kain, L. W., & McMain, S. F. (2012). Neural correlates of negative emotionality in borderline personality disorder: An activation-likelihood-estimation meta-analysis. Biological Psychiatry, 73(2), 153–160. doi:10.1016/j.biopsych.2012.07.014.

  • Stanley, B., & Siever, L. J. (2010). The interpersonal dimension of borderline personality disorder: Toward a neuropeptide model. The American Journal of Psychiatry, 167(1), 24–39. doi: appi.ajp.2009.09050744 [pii] 10.1176/appi.ajp.2009.09050744 [doi].

    Google Scholar 

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Acknowledgments

This research is supported by the Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment, the Medical Research Service of the Veterans Affairs James J Peters VAMC, and the Department of Veterans Affairs NY/NJ (VISN3) Mental Illness Research, Education, and Clinical Center (MIRECC).

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Authors and Affiliations

  1. Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box #1230, One Gustave L. Levy Place, New York, NY, 10029, USA

    Marianne Goodman

  2. The Mental Health Patient Care Center and the Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA

    Marianne Goodman

  3. Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

    M. Mercedes Perez-Rodriguez & Larry Siever

  4. The Mental Health Patient Care Center and the Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA

    M. Mercedes Perez-Rodriguez & Larry Siever

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  1. Marianne Goodman
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  2. M. Mercedes Perez-Rodriguez
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  3. Larry Siever
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Correspondence to Marianne Goodman .

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Editors and Affiliations

  1. Dept. Psychology, University of Houston, Houston, Texas, USA

    Carla Sharp

  2. Dept. Psychology, University of Houston, Houston, Texas, USA

    Jennifer L. Tackett

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Goodman, M., Perez-Rodriguez, M.M., Siever, L. (2014). The Neurobiology of Adolescent-Onset Borderline Personality Disorder. In: Sharp, C., Tackett, J. (eds) Handbook of Borderline Personality Disorder in Children and Adolescents. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0591-1_9

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