Abstract
In general, phase-II metabolites of drugs, such as sulfates, O- or N-glucuronides, were anticipated to be rapidly excreted into urine and bile without exhibiting significant biological/pharmacological activity. However, a few years ago various conjugates were proven to have considerable affinity to pharmacological receptors or to contribute to toxic effects. Today, it is largely accepted that they may be active and/or reactive [Kroemer and Klotz, 1992; Spahn-Langguth and Benet, 1992a, b].
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Spahn-Langguth, H., Dahms, M., Hermening, A. (1996). Acyl Glucuronides. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_39
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