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Myocardial Ischemia and Lipid Metabolism

  • Book
  • © 1984

Overview

Editors:
  1. R. Ferrari

    1. University of Brescia, Brescia, Italy

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  2. A. M. Katz

    1. School of Medicine, University of Connecticut Health Center, Farmington, USA

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  3. A. Shug

    1. William S. Middleton Memorial Veteran Hospital, Madison, USA

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  4. O. Visioli

    1. University of Brescia, Brescia, Italy

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Lipid Metabolism in the Myocardium

    1. Overview of Lipid Metabolism

      • N. Siliprandi, F. Di Lisa, C. R. Rossi, A. Toninello
      Pages 1-13

    2. Factors Influencing the Carnitine-Dependent Oxidation of Fatty Acids in the Heart

      • J. Bremer, E. J. Davis, B. Borrebaek
      Pages 15-26

    3. Localization and Function of Lipases and their Reaction Products in Rat Heart

      • W. C. Hülsmann, H. Stam, J. M. J. Lamers
      Pages 27-37

    4. Ultrastructural Localization of Lipids in Myocardial Membranes

      • N. J. Severs
      Pages 39-61

  3. Lipid Induced Membrane Abnormalities

    1. Phospholipase-Induced Abnormalities in the Sarcolemma

      • N. A. Shaikh, I. Parson, E. Downar
      Pages 63-80

    2. A Surface Charge Hypothesis for the Actions of Palmitylcarnitine on the Kinetics of Excitatory Ionic Currents in Heart

      • A. J. Pappano, D. Inoue
      Pages 81-106

    3. Modulation of Membrane Function by Lipid Intermediates: A Possible Role in Myocardial Ischemia

      • J. M. J. Lamers, J. T. Stinis, A. Montfoort, W. C. Hülsmann
      Pages 107-125

    4. Fatty Acid Effects on Sarcoplasmic Reticulum Function in Vitro

      • F. C. Messineo, M. Rathier, J. M. Watras, H. Takenaka, A. M. Katz
      Pages 127-134

  4. Ischemia and Lipid-Induced Changes in Myocardial Function

    1. Factors Influencing the Metabolic and Functional Alterations Induced by Ischemia and Reperfusion

      • R. Ferrari, F. Di Lisa, R. Raddino, C. Bigoli, S. Curello, C. Ceconi et al.
      Pages 135-157

    2. Factors that Influence Myocardial Levels of Long-Chain Acyl CoA and Acyl Carnitine

      • J. R. Neely, K. H. McDonough
      Pages 159-169

    3. Are Tissue Non-Esterified Fatty Acids (NEFA) Involved in the Impairment of Biochemical and Mechanical Processes during Acute Regional Ischemia in the Heart

      • G. J. van der Vusse, F. W. Prinzen, R. S. Reneman
      Pages 171-184

    4. Effects of Myocardial Ischemia and Long Chain Acyl CoA on Mitochondrial Adenine Nucleotide Translocator

      • D. J. Paulson, A. L. Shug
      Pages 185-202

  5. Interventions Used to Modify Lipid-Induced Abnormalities in the Heart

    1. Fatty Acid and Carnitine-Linked Abnormalities During Ischemia and Cardiomyopathy

      • A. L. Shug, D. J. Paulson
      Pages 203-224

    2. Consequences of Fatty Acid Excess in Ischemic Myocardium and Effects of Therapeutic Interventions

      • A. J. Liedtke, W. P. Miller
      Pages 225-241

    3. Membrane Phospholipid Metabolism during Myocardial Ischemia: Mechanisms of Accumulation of Unesterified Arachidonate

      • K. R. Chien, L. M. Buja, J. T. Willerson
      Pages 243-250

    4. Phospholipase and Ischemic Damage: Possibilities of Interventions

      • M. Chiariello, G. Ambrosio, M. Cappelli-Bigazzi, G. Marone, M. Condorelli
      Pages 251-265

  6. Importance of Lipid Metabolism in Man

    1. Cardiac Perfusion, Past and Present

      • R. J. Bing
      Pages 267-281

    2. Clinical Relevance of Free Fatty Acid Excess

      • L. H. Opie, M. J. Tansey, J. de Leiris
      Pages 283-295

    3. Iodine-123 Phenylpentadecanoic Acid: Detection of Acute Myocardial Infarction in Anesthetized Dogs

      • J. S. Rellas, J. R. Corbett, P. Kulkarni, C. Morgan, M. Devous, L. M. Buja et al.
      Pages 297-305
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Keywords

About this book

Over the past years, the thrust of research in cardiology has been toward an understanding of the engineering of the heart as a pump that transports blood to the various organs of the body. More recently, the fields of biochemistry and biophysics have come to influence heart research. The modern cardiologist can no longer pretend to understand, for example, what is happening to the patient with myocardial infarction or ischemia without understanding the principles of molecular biology. The structure and function of the heart are therefore central themes of cardiological research and practice, which incorporate knowledge and discoveries from diverse disciplines. The importance of lipid metabolism in the myocardium has become clearly understood. In the well-oxygenated heart, fatty acids are the preferred substrates. The fact that the heart derives most of its energy from the oxidation of lipids, which represent the larg­ est energy store of the body, is logical for an organ that must work throughout our lifetime. There are, however, several lines of evidence that during ischemia, lipids may. be harmful to the heart. High levels of free fatty acids in the serum have been suggested to play a role in causing life-threatening arryhthmias and damage in the ischemic heart. The molecular basis for these effects remains poorly understood, and several possible mechanisms for these harm­ ful effects have been suggested.

Editors and Affiliations

  • University of Brescia, Brescia, Italy

    R. Ferrari, O. Visioli

  • School of Medicine, University of Connecticut Health Center, Farmington, USA

    A. M. Katz

  • William S. Middleton Memorial Veteran Hospital, Madison, USA

    A. Shug

Bibliographic Information

  • Book Title: Myocardial Ischemia and Lipid Metabolism

  • Editors: R. Ferrari, A. M. Katz, A. Shug, O. Visioli

  • DOI: https://doi.org/10.1007/978-1-4684-4865-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1984

  • Softcover ISBN: 978-1-4684-4867-2Published: 13 March 2012

  • eBook ISBN: 978-1-4684-4865-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 342

  • Topics: Cardiology

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