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Prostacyclin

  • Chapter
The Prostaglandin System

Part of the book series: NATO Advanced Study Institutes Series ((ASIAS))

Abstract

In 1976, the Wellcome group discovered that prostaglandin endoperoxides were transformed by a microsomal enzyme from blood vessels into an unstable substance which is a potent vasodilator and an inhibitor of platelet aggregation (13,14, 75,76, 42). This compound originally called PGX was later chemically identified as an intermediate in the formation of 6-oxo-PGFlα, a compound described earlier (95). PGX was then renamed prostacyclin and given the abbreviation of PGI2 (61).

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Authors and Affiliations

  1. Wellcome Research Laboratories, Langley Court, Beckenham, Kent, UK

    S. Moncada & J. R. Vane

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  1. S. Moncada
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  2. J. R. Vane
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Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti

  2. University of Padua, Verona, Italy

    G. P. Velo

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© 1981 Plenum Press, New York

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Moncada, S., Vane, J.R. (1981). Prostacyclin. In: Berti, F., Velo, G.P. (eds) The Prostaglandin System. NATO Advanced Study Institutes Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3896-3_16

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  • DOI: https://doi.org/10.1007/978-1-4684-3896-3_16

  • Publisher Name: Springer, Boston, MA

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