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Extracellular Cyclic Nucleotide Metabolism in the Human Central Nervous System

  • Chapter
Neurobiology of Cerebrospinal Fluid 1

Abstract

The cyclic nucleotides—adenosine-3′,5′-cyclic mon-ophosphate (cAMP) and guanosine-3′,5′-cyclic monophosphate (cGMP)—serve important metabolic functions in many mammalian tissues (Fig. 1). Glycogen metabolism is the best-studied example of the regulatory function of cAMP in the phosphorylation of phosphorylase b to phosphorylase a.134 The proven and hypothetical roles of cyclic nucleotides in human nonneurological disease have been described in detail elsewhere.7,12,13,69,84,97,149,151 The role of cyclic nucleotides in human neurological diseases is beginning to be explored.24,52,53,158 The evidence defining the importance of cyclic nucleotides in many facets of central and peripheral nervous system functions is briefly reviewed below.34,35,38,81,106,114

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Authors and Affiliations

  1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Benjamin Rix Brooks M.D.

  2. Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Benjamin Rix Brooks M.D.

  3. Division of Neurosurgery, University of Pennsylvania School of Medicine and Hospital, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D.

  4. Endocrinology Division, Department of Medicine, National Naval Medical Center, Bethesda, Maryland, 20014, USA

    Maria Diaz B.S. & Leon P. Georges M.D.

  5. Department of Obstetrics and Gynecology, Uniformed Services University of Health Sciences, School of Medicine, Bethesda, Maryland, 20014, USA

    Carol Czerwinski Ph.D.

  6. Medical Service, Carbondale Veterans Administration Hospital, Carbondale, Illinois, 62901, USA

    Jonas Sode M.D.

  7. Department of Internal Medicine, Southern Illinois University School of Medicine, Carbondale, Illinois, 62901, USA

    Jonas Sode M.D.

  8. Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Michael H. Ebert M.D.

  9. Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20205, USA

    W. King Engel M.D.

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  1. Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D. (Consultant) (Consultant)

  2. Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, Maryland, 20205, USA

    James H. Wood M.D. (Consultant) (Consultant)

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Rix Brooks, B. et al. (1980). Extracellular Cyclic Nucleotide Metabolism in the Human Central Nervous System. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_9

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