Abstract
There are the biologically proven facts that first, 10B-p-BPA accumulates 10B in melanoma cells, and second, the accumulation is not permanent. After reaching a saturation concentration, melanoma cells release boron1,2,3,4. The reason for the accumulation has been considered as follows. 1. p-BPA resembles L-tyrosine or L-DOPA, which are precursors of melanin synthesis. 2.The melanin synthesis path is very active in melanoma cells. 3. Therefore, p-BPA might be incorporated to the melanin synthesis path.
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Yoshino, K., Maruyama, T., Mori, Y., Kakihana, H., Mishima, Y. (1993). Capture of p-Boronophenylalanine by Melanin-Related Compounds: Complex Formation of p-Boronophenylalanine with L-Dopa. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_50
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DOI: https://doi.org/10.1007/978-1-4615-2978-1_50
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