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Apoptosis: The Eyes Have It

  • Chapter
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

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Abstract

Inflammatory immune responses are necessary for host protection against environmental pathogens. Critical to a successful immune response is the clonal expansion of specific lymphocytes. However, after infection, homeostasis must be returned to the immune system to prevent the development of tissue damage that could lead to autoimmunity. CD95-CD95L-mediated apoptosis is a central component of this process.1 Indeed, mice deficient in functional CD95 or CD95L (lprandgld, respectively) suffer from massive accumulation of lymphocytes and loss of self-tolerance. 2 In addition to reducing lymphocyte numbers, induction of apoptosis is associated with regulation or prevention of inflammatory responses to normal cellular antigens.3

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences and Department of Pathology, Missouri, USA

    Bennett D. Elzey

  2. Washington University School of Medicine St. Louis, Missouri, USA

    Thomas A. Ferguson

Authors
  1. Bennett D. Elzey
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  2. Thomas A. Ferguson
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Elzey, B.D., Ferguson, T.A. (2002). Apoptosis: The Eyes Have It. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_115

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_115

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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